Ppt on juvenile rheumatoid arthritis

Arthritis is the inflammation of one or more joints, accompanied by joint pain called arthralgia, swelling, stiffness, and loss of movement of the joints.

away, a lack of synovium fluid, autoimmunity (the body attacking itself), infection, or a combination of different factors. M ORE THAN 100 TYPES Juvenile rheumatoid arthritis which affects people younger than the age of 16. There are 3 main types of Juvenile arthritis: 1. Pauciarticular, which is the most common and mildest. The person experiences pain in up to 4 joints. 2. Polyarticular, which affects/

Arthropathies/Connective Tissue Diseases 1. 1. Osteoarthritis (DJD) 2. Rheumatoid Arthritis 3. Ankylosing Spondylitis 4. Psoriatic Arthritis 5. Reiter.

(< 45 years) Enteropathic arthropathy Ulcerative colitis4:1 Crohns disease1:1 AGE Age GroupAge of OnsetDisorder Young (< 20 years)< 20 years Juvenile chronic arthritis Septic arthritis Middle (> 20 years) onset 15 - 35 years Ankylosing spondylitis Reiters Young adults Enteropathic arthropathies 25 - 55 years Rheumatoid arthritis Psoriatic arthritis Older patients (> 55 years) > 55 years Osteoarthritis DISH CPPD Neurologic and Musculoskeletal Imaging Studies Chapter 7 part 2 Osteoarthritis (DJD/

Overview of Arthritis Brought to you in collaboration by: 1. Arthritis Foundation Tennessee Chapter 2. Tennessee Department of Health 3. University of.

Joints Most Often Affected Osteoarthritis most often occurs at the ends of the fingers, thumbs, neck, lower back, knees, and hips. 11 Types of Arthritis Osteoarthritis (OA) Rheumatoid Arthritis (RA) Fibromyalgia Syndrome (FMS) Lupus – Systematic Lupus Erythematosus (SLE) Juvenile Rheumatoid Arthritis (JRA) 12 Osteoarthritis (OA): By Far The Most Common Form Also called degenerative joint disease Usually begins after age 45 Causes symptoms in 1 of/

Measurement Considerations In Rheumatology: Integrating Biomarkers, Technology, Safety, and Comorbidities to Assess Risks and Benefits of Treatment Jeffrey.

on Measurement Biomarker-Based Assessment of RA Disease Activity Technology-based approaches Safety Infections GI Perforations CV Events Biologics Revolutionary for Many Diseases Ankylosing spondylitis Inflammatory bowel disease Juvenile Idiopathic arthritis (JIA) Psoriasis Psoriatic arthritis Rheumatoid arthritis (RA) Multiple sclerosis Systemic lupus Gout In large randomized controlled trials, shown to yield Improved disease related outcomes Improved function Improved quality of life Improved work and/

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BioPharma The Spondyloarthropathies Kathryn Dao, MD Arthritis Center September 15, 2005.

1 to 10:1  Females have less severe  Insidious disease onset between 16-30 yrs. Rare after 45 yrs.  Juvenile spondylitis: males >9yrs old Modified New York Criteria for AS  Clinical criteria  Low back pain and stiffness for >3 / Abx do not affect outcome of Shigella, Salmonella infection What is the diagnosis? a)Bad manicure b)Rheumatoid arthritis c)Psoriatic arthritis d)Erosive OA PSORIATIC ARTHRITIS (PsA)  Chronic inflammatory arthropathy in setting of psoriasis  Etiology and genotype unclear  1-5%/


administered the situation can temporarily worsen at first. Ensure the patient drinks sufficient quantities of water. HAPTENS San Acne Acne Rheumatoid arthritis Haptens San Brucel Arthritis of all types, always consider tubercular origins. HAPTENS San Myc Arthritis of all types, always consider tubercular origins. Juvenile acne Osteochondritis HAPTENS San Pseu Autoimmune diseases Fibrositis arthropathica Treatment of complaints caused by an immuno suppressive treatment POLYSANS A/

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should i take methotrexate for psoriatic arthritis methotrexate dose for juvenile rheumatoid arthritis second dose of methotrexate for ectopic pregnancy methotrexate rash on neck can i stop taking methotrexate for rheumatoid arthritis methotrexate tablet dosage for abortion methotrexate/ Pobres y convertirse en realidad slo dos sodium bicarbonate before methotrexate usual dosage of methotrexate for rheumatoid arthritis To envision the inside of your engine-house, whence these noises proceeded, was now a /

New Pharmacologic Treatment Options for Managing Rheumatoid Arthritis Devra Dang, Pharm.D. Department of Pharmacy National Institutes of Health.

who are allergic to sulfa drugs Vioxx ® and Mobic ® are not FDA-approved for the treatment of rheumatoid arthritis Disease-Modifying Antirheumatic Drugs (DMARDs) Azathioprine (Imuran ® ) Gold Hydroxychloroquine (Plaquenil ® ) Leflunomide (Arava /methotrexate –Delays the rate of progression of joint erosions better than methotrexate Effective in patients with juvenile rheumatoid arthritis Enbrel ® (Etanercept) Administration: twice a week subcutaneous injection Adverse effects –Injection site reactions/

Are Herbal Medicines Effective In Relieving Arthritis Joint Pain And Inflammation?

and it can affect anyone, regardless of age or sex. Relieve Arthritis Joint Pain And Inflammation It is usually manifested in the form of osteoarthritis, rheumatoid arthritis or juvenile arthritis. Osteoarthritis is a progressive degeneration of cartilages resulting in inflammation and pain. Patients affected by rheumatoid arthritis show inflamed membranes of joints, stiffness and damage. Juvenile arthritis is the result of immune disorders manifesting itself in children below 16/

 Normal knee anatomy  Symptoms and pathology of juvenile rheumatoid arthritis  Pain management  Stages of development and psychosocial issues  Multidisciplinary.

management  Stages of development and psychosocial issues  Multidisciplinary approach Anatomy of the knee Synovial joint components What is juvenile rheumatoid arthritis?  Joint contracture  Joint inflammation  Joint damage  Alteration or change in growth Juvenile idiopathic arthritis Polyarticular JRA - typically affects 5 or more joints Systemic onset JRA - high spiking fevers and rash Oligoarticular JRA - typically affects 4 or fewer joints Pauciarticular JRA - may cause eye inflammation/

INTRODUCTION TO RHEUMATOLOGY KATHRYN DAO, MD Arthritis Consultation Center July 21, 2005.

Mono/Oligo vs Polyarticular Less than 4 joints Osteoarthritis Fracture Osteonecrosis Gout or Pseudogout Septic arthritis Lyme disease Reactive arthrtis Tuberculous/Fungal arthritis Sarcoidosis 4 or more joints Osteoarthritis Rheumatoid arthritis Psoriatic arthritis Viral arthritis Serum Sickness Juvenile arthritis SLE/PSS/MCTD History: Clues to Diagnosis Age Young: JRA, SLE, Reiters, GC arthritis Middle: Fibromyalgia, tendinitis, bursitis, LBP RA Elderly: OA, crystals, PMR, septic, osteoporosis Sex Males/

The Itis Family Osteo Rheum Psoriatic Reactive Juvenile rheumatoid Gouty.

The Itis Family Osteo Rheum Psoriatic Reactive Juvenile rheumatoid Gouty Osteoarthritis OA, the most common arthritis, affects more than 21 million Americans and is a leading cause of disability. At present, there is no available therapy that can reverse the damage of OA in the joint, but many studies are underway. Rheumatoid arthritis a chronic disease that causes pain, stiffness, swelling, and limitation in the motion/


JA symmetrical >3 Psoriatic Reactive no yes PCP,MCP/ MTP yes Rheumatoid no SLE/Scleroderma no CAUSES:M ONO / OLIGO ARTHRITIS Septic Arthritis–Bacteria,fungal,parasitic arthritis Internal derangement or trauma –Meniscus Injury –Ligament tears - hemarthrosis  crystal-induced arthritis  Charcot joint  Psoariatic arthritisJuvenile Rheumatoid Arthritis(pauci articular)  Mono art.presentation of c/c arthritis  Ischemic bone (avascular necrosis  Neoplasms –Villonodularsynovitis S EPTIC A RTHRITIS : R/

Tim Badcock Monday, 10 th March 2014. Layout Osteoarthritis Rheumatoid arthritis Case studies.

aids Prognosis Excellent Not life limiting Associated with cardiovascular disease, obesity Significant impairment of ADLs Rheumatoid arthritis Definition Aetiology Risk factors Signs and symptoms Extra-articular manifestations Investigations Management DMARDs Definition A chronic/characterised by joint laxity, swelling and reduction in function with additional systemic effects Forms Juvenile idiopathic arthritis (Pauci/polyarticular) Still’s disease Symmetrical polyarthropathy Vasculitis RhF +ve and –ve/

L1 Juvenile Rheumatoid Arthritis Clinical Overview Daniel J. Lovell MD, MPH Levinson Professor of Pediatrics Division of Rheumatology Cincinnati Children’s.

L1 Juvenile Rheumatoid Arthritis Clinical Overview Daniel J. Lovell MD, MPH Levinson Professor of Pediatrics Division of Rheumatology Cincinnati Children’s Hospital Medical Center Cincinnati/ Commonly Reported in JRA Lovell and Walco. Pediatr Clin North Am 1989; 36:1015-27 Self report of pain from 462 children with JRA Cincinnati Juvenile Arthritis Database L4 Functional Impact of Pain in Children with JRA Parent’s assessment of activities affected by child’s pain 22% pauciarticular course 48% polyarticular /

Arthritis and Stress… By Jack Schetter The Nature of Arthritis  Occurs within the joint (area where two bones meet)  Inflammation of one or more joints.

Causes include:  An Auto immune disease (Body’s immune system mistakenly attacks healthy tissue)  Broken Bone  General Wear and Tear  Infection cause by bacteria or virus Common Types of Arthritis Include:  Gout  Juvenile Rheumatoid ArthritisRheumatoid Arthritis  Scleroderma Signs and Symptoms include…  Joint Pain  Swelling  Stiffness  Reduced Mobility  Warmth Around the Joint  Redness of the Skin Around the Joint Signs and Tests Physical Exam checks for/

Spondyloarthropathies. Spondyloarthropathias include the following Ankylosing spondylitis,Reiters syndrome or reactive arthritis,Arthropathy of inflammatory.

disease, ulcerative colitis),Psoriatic arthritis,Undifferentiated spondyloarthropathies,Juvenile chronic arthritis and juvenile-onset ankylosing spondylitis. Clinical Characteristics of Spondyloarthropathies are: Typical pattern of peripheral arthritis— predominantly of lower limb, asymmetric Tendency toward radiographic sacroiliitis,Absence of rheumatoid factor,Absence of subcutaneous nodules and other extra-articular features of rheumatoid arthritis,Overlapping extra-articular features characteristic/

Disease Modifying Antirheumatic drugs. At the end of the lecture the students should: Know the pathogenesis of rheumatoid joint damage Emphasize the rational.

work disabled at 10 years Severe disease is associated with increased mortality classification Drugs for Rheumatoid Arthritis DMARDs ClassicalBiologic NSAIDsGlucocorticoids May be administered in low to moderate doses to achieve rapid disease control/ in patients with active rheumatoid arthritis not responding to TNF blockers or other biologic drugs tocilizumab Used as monotherapy in adult with rheumatoid arthritis or in children over 2 years with systemic juvenile arthritis Infusion reactions adrs Serious /

1.  My name is _________________.  I was born in ________________.  My dog is named ________________.  I have JIA, which is short for juvenile idiopathic.

it can’t be cured. Not all surprises are good. 5 Evan was in kindergarten when “weird pains” started to bother him. It was juvenile arthritis. He hopes the medicines he takes will let him play sports again. He likes soccer, gymnastics and riding his bike. 6 Mia was 9 / got a super high fever and had to stay in the hospital for a while. Doctors eventually figured out she has juvenile rheumatoid arthritis. Kiana was 2 years old when her legs hurt so much she stopped walking. 9 Then Natalie couldn’t open jars/

Treatment Management of Rheumatoid Arthritis. Findings and In Depth Analysis.

Split According to Disease Severity (Percentage) Rheumatoid Arthritis Ankylosing Spondylitis Psoriatic Arthritis Juvenile Rheumatoid Arthritis Others In KSA, Rheumatologists see an average of 346 Patients per month, out of which 75 are Rheumatoid Arthritis accounting for 22% of the total,/ and In Depth Analysis Overall Prescription Shares of different therapeutic classes used in the treatment of Rheumatoid Arthritis (KSA) DMARDs are prescribed to almost 90%Patients with RA, followed by NSAIDs Biologics are/

Understanding the Impact of Arthritis Across the Working Life Course: A Canadian Context Arif Jetha 1, Elizabeth M. Badley 2,3, Dorcas Beaton 4,5, Monique.

Toronto 3 Toronto Western Research Institute, University Health Network 4 Mobility Program, Clinical Research Unit, St. Michaels Hospital, Toronto 5 Institute for Work and Health, Toronto, Canada Arthritis Group of 100 autoimmune conditions Rheumatoid arthritis, osteoarthritis, juvenile arthritis, lupus, gout Inflammation joints, connective tissues Affect all parts of the body Range of symptoms Pain, fatigue, rash, failure to organs Episodic and invisible Contributes to activity/

Arthritis: The Disease, The Program & Interventions Debbie Campbell MBA, CHES Arthritis Health Section Chief Department of Health & Human Services - Division.

annually Outline Arthritis – Economic & Disease Burden Arthritis – Economic & Disease Burden Arthritis Health Program Arthritis Health Program Arthritis Management Arthritis Management Arthritis – Economic & Disease Burden Arthritis – Economic & Disease Burden Arthritis Health Program Arthritis Health Program Arthritis Management Arthritis Management Arthritis is an umbrella term Rheumatoid Arthritis Fibromyalgia Gout Lyme Disease Bursitis Lupus Juvenile Arthritis Ankylosing Spondylitis Osteoarthritis/

Arthritis Foundation Indiana Chapter Amber Wolfe AgrAbility Project Coordinator.

in the USArthritis is one of the leading causes of disability in the US Common Forms of Arthritis in the US Osteoarthritis- 27 millionOsteoarthritis- 27 million Rheumatoid Arthritis- 1.3 millionRheumatoid Arthritis- 1.3 million Gout- 3 millionGout- 3 million Fibromyalgia- 5 millionFibromyalgia- 5 million Juvenile Rheumatoid Arthritis- 300,000Juvenile Rheumatoid Arthritis- 300,000 Osteoarthritis Osteoarthritis Usually begins after age 40Usually begins after age 40 Affects only certain joints/

Investigation of Systemic Juvenile Idiopathic Arthritis (SJIA): a disease of dysregulated innate inflammation Betsy Mellins, MD Divisions of Human Gene.

– Pro-inflammatory cytokines Examples – FMF, NOMID, MWS, FCU, TRAPS – SJIA Juvenile Idiopathic Arthritis (JIA) A group of conditions – 7 subtypes Characterized by: – Arthritis (joint inflammation) for > 6 weeks – Onset age < 16 years Prevalence: 8/ to treat (steroids, NSAIDS); significant proportion has relatively poor response to current drugs that show benefit in rheumatoid arthritis (e.g.,MTX, anti- TNFα). The SJIA project Comprehensive immunological phenotyping of patients in association with clinical/

Welcome to the Arthritis Foundation’s Introduction To Arthritis!

+ IT IS = (Joint)(Inflammation) INFLAMMATION OF THE JOINTS OsteoarthritisRheumatoid Arthritis Ankylosing Spondylitis Fibromyalgia Lupus Gout Bursitis Juvenile Rheumatoid Arthritis Osteogenesis Imperfecta Myositis Scleroderma Lyme Disease Carpel TunnelPsioriatic Arthritis Arthritis is an umbrella term for over 100 types of rheumatic diseases Its Prevalence and Impact  A new CDC report (2006) says that 46 million Americans have arthritis (1 in 5)  The #1 cause of Disability in the U/

Arthritis Advisory Committee July 29, 2008 Actemra (tocilizumab) for Rheumatoid Arthritis FDA Perspective Sarah Okada, M.D. Division of Anesthesia, Analgesia,

29, 2008 Actemra (tocilizumab) for Rheumatoid Arthritis FDA Perspective Sarah Okada, M.D. Division of Anesthesia, Analgesia, and Rheumatology Products Sarah Okada, M.D. Division of Anesthesia, Analgesia, and Rheumatology Products Arthritis Advisory Committee July 29, 2008 2 /trial – assess safety of add-on therapy w prevalent DMARD regimens Phase 4 –Early RA, 1 st line treatment –Juvenile Idiopathic Arthritis (JIA) –Comparative studies –Long-term (e.g. 5 year) safety studies –Study of impact of treatment on/

Arthritis from 36,000 feet An Overview Paul F. Howard MD, FACP, FACR Director, Arthritis Health 9097 E. Desert Cove #100 Scottsdale, AZ, 85260

Diagnosis Traumatic Mechanical / Degenerative Metabolic ------------------------------------------ Infectious Inflammatory Crystal related ------------------------------------------ Malignancy Inflammatory Monoarthritis Reactive Arthritis (Post infectious) Psoriatic Arthritis Ankylosing Spondylitis Juvenile Inflammatory Arthritis JIA Onset of a chronic polyarthritis - ? rheumatoid arthritis Malignancy Osteosarcoma Metastatic Tumor Pigmented Villonodular Synovitis Rare tumor of cartilage, bone and muscle/

A complex and severe disabling disease

% to 42% of patients with Pso will develop arthritis3 Psoriatic Arthritis A chronic and inflammatory arthritis in association with skin psoriasis4 Usually rheumatoid factor (RF) negative and ACPA negative5 Distinct from RA Psoriatic Arthritis is classified as one of the subtypes of spondyloarthropathies Characterized by synovitis, enthesitis, dactylitis, spondylitis, skin and nail psoriasis4 Juvenile SpA Reactive arthritis Arthritis associated with IBD PsA Undifferentiated SpA (uSpA) Ankylosing spondylitis/

OPM Session #10. Audience: People with Rheumatoid Arthritis (RA), family, care givers, maybe healthcare or social workers that work with RA patients.

Choices for RA. Help other RA patients rebuild their health and lives so they can reach full potential, especially children with Juvenile RA. I’d like to help others regain a life with bundles of energy, flexibility and strength while reducing or eliminating/, etc. Present actionable info or content: Monthly teleseminars or webinars 1.There are at least 15 different sets of triggers for rheumatoid arthritis flares. 2.List all 15. Today I’d like to talk about how to pick one that may be giving you trouble/

Arthritis is defined as inflammation of the joints and comes in 3 forms:  Osteoarthritis ArthritisRheumatoid ArthritisJuvenile Arthritis.

in 3 forms:  Osteoarthritis ArthritisRheumatoid ArthritisJuvenile Arthritis  Pain in joints.  Tenderness of joints.  Joints may be stiff.  Loss of flexibility There are a number of natural supplements that may be taken to relieve arthritis symptoms:  Pine Bark  /use of pain medication  Reduced stiffness  Improvement in physical function  Enhanced in overall well being (Arthritis Foundation, 2013) http://www.youtube.com/watch?v=GsJVimGc980 Glucosamine is a natural supplement that is found in/

Degenerative Disc Disease is Arthritis of the Spine Stephen Fuller, MD Impartial Medical Opinions1.

been a major topic of research interest. Furthermore, extensive therapeutic studies in the field of osteoarthritis and rheumatoid arthritis have highlighted the need to identify the underlying signalling pathways, prompting scores of IVD researchers to explore the/ physical component (p = 0.032) of the SF-36. CONCLUSIONS: This study demonstrated that the presence of juvenile disc degeneration was strongly associated with overweight and obesity, low back pain, increased low back pain intensity, and diminished/

Juvenile Idiopathic arthritis and infectious arthritis 郭三元 Division of R-I-A TSGH.

Juvenile Idiopathic arthritis and infectious arthritis 郭三元 Division of R-I-A TSGH Juvenile rheumatoid arthritis Juvenile chronic arthritis Juvenile Idiopathic arthritis  Polyarticular type (20-30%)  Oligoarticular type (50-60%)  Systematic types (10%)  Enthesitis-related arthritis  Psoriatic arthritis 5 joints or more 4 joints or less Juvenile idiopathic arthritis  Prevalence:12-113/100000, incidence 9- 25/100000  Age of onset < 16 years  Disease duration > 6 weeks  In oilgo- and poly- type: female/

Working Together to Help Children with Juvenile Idiopathic Arthritis

rheum Unclear what ultimately prompts referral to paed rheum ? – this is part of our ongoing research What is Juvenile Idiopathic Arthritis? Most common childhood chronic disease causing disability. About 7/100,00 newly diagnosed children with JIA per year. Prevalence/A child with joint pain (but no arthritis) must have JIA. All arthritis is painful. If a child has a positive rheumatoid factor, they must have arthritis. If x-rays are normal, there is no arthritis. The JIA Module: Helping you with Diagnostic/

Www.pspbc.ca MSK Train the Trainer 1 Arthritis and Low Back Pain Wireless: Westin-Meeting Code: bcma2013 Westin Wall Centre April 4-5, 2013.

. Referral to a rheumatologist prior to medication initiation What is best practice for the management of Rheumatoid Arthritis? Program Orientation Dr. Diane Lacaille 14  Patient’s journey  Gap analysis  Evidence-informed practice guidelines  Juvenile idiopathic arthritis  Clinical tools  Application to practice with video  Shared care panel  Practice implementation Rheumatoid Arthritis and Osteoarthritis 15  To discuss a comprehensive approach to improve FP care and supports for patients/

A1 29 November 2006 FDA Advisory Committee Meeting Celecoxib in the Treatment of the Signs and Symptoms of Juvenile Rheumatoid Arthritis (JRA)

Advisory Committee Meeting Celecoxib in the Treatment of the Signs and Symptoms of Juvenile Rheumatoid Arthritis (JRA) A2 Delegation Dr Edward GianniniEpidemiology Cincinnati Children’s Hospital Medical Center /from baseline to each post-baseline assessment for: – Each ACR Pediatric 30 core set measure – Parent’s Assessment of Child’s Arthritis Pain (VAS) [CHAQ Subsection] Celecoxib pharmacokinetics in pediatric patients Safety Adverse events Clinical laboratory values Vital signs A30 Study 195: Statistical/

High Density SNP analysis of 642 Caucasian Families with Rheumatoid Arthritis Identifies Two Novel Regions of Linkage on Chromosomes 11p12 and 2q33 Christopher.

other autoimmune disorders including type 1 diabetes, autoimmune thyroid disease, systemic lupus erythematosus and some forms of juvenile arthritis. – additional variability in the PTPN22 locus may account for a more minor proportion of risk for RA/ 19 on XYp and 7 are on XYq 642 Caucasian families containing affected sibling pairs with rheumatoid arthritis, recruited by the North American Rheumatoid Arthritis Consortium (NARAC) – Table 1. Structure and sampling of 642 caucasian sibling pair families studied/

Total Knee Arthroplasty in Juvenile Rheumatoid Arthritis by David H. Palmer, Kevin J. Mulhall, Corey A. Thompson, Erik P. Severson, Edward R.G. Santos,

Volume 87(7):1510-1514 July 1, 2005 ©2005 by The Journal of Bone and Joint Surgery, Inc. Preoperative standing anteroposterior radiograph of a patient with a history of polyarticular juvenile rheumatoid arthritis since the age of four years. David H. Palmer et al. J Bone Joint Surg Am 2005;87:1510- 1514 ©2005 by The Journal of Bone and Joint Surgery, Inc/


MD PhD 3, Fatmir Dragidella DDS PhD 1, Valmira Maxhuni DDS 1, Arben Murtezani DDS 4 OBJECTIVE  To investigate the oral health status and related concomitant disease in children with juvenile rheumatoid arthritis (JRA). SETTING  The study was conducted at the Pediatric Department of the University Clinical Center of Kosovo in Prishtina, in order to improve the oral health care awareness among patients/

Val Eyre Events Fundraiser National Rheumatoid Arthritis Society.

to ignore it are common place. This is where NRAS fits in... ‘A better life for those living with Rheumatoid Arthritis We achieve this by:  Providing information, support, education and advocacy  Raising public awareness of the disease / and healthcare professionals  Developing a new support and information service for the 12,000 children and young people living with Juvenile Idiopathic Arthritis (JIA)  First RA Awareness Week, 2013  New publication - The Impact of RA on Emotions, Relationships and /

Arthritis 101 Arthritis Information line 1-800-321-1433 (ext. 1)

market and healthcare costs annually You Are Not Alone! Affects one in six Canadians More women than men are affected Juvenile arthritis affects those under the age of 16 More than 100 different types A cure has yet to be found Joint Points/ of years D I I D Inflammatory or Degenerative? Let’s reviewI or D? Affects fewer joints and tends to be asymmetrical Rheumatoid arthritis Pain and swelling in weight-bearing joints such as knees and hips Requires a trigger – viral or environmental Tends to occur in /

LYME DISEASE. I. I.Epidemiology A. A.Originally described after cluster of cases of JRA (juvenile rheumatoid arthritis) – like disease in Lyme, CT in.

LYME DISEASE I. I.Epidemiology A. A.Originally described after cluster of cases of JRA (juvenile rheumatoid arthritis) – like disease in Lyme, CT in 1977 ; causative spirochete identified in 1982 B. B.Causative spirochete / within 6 months. Knee and TMJ commonly affected. 10 to 20 % / year spontaneous remission rate. 3. 3.Chronic Lyme arthritis : resembles refractory rheumatoid arthritis. All patients with this have high IgG titers. May need arthoscopic synovectomy for Rx. LYME DISEASE C. C.Stage III (due/

Connective Tissue Diseases & Dermatology. OUTLINE Introduction Lupus Dermatomyositis/Polymyositis Scleroderma –Systemic –Localized Rheumatoid Arthritis.

Discoid LE Scarring alopecia with follicular plugging Scalp hair-bearing areas Dermatomyositis/Polymyositis DM/PM Epidemiology –Bimodal distribution Juvenile form Adult form (>40 yrs) –Males = females –Blacks to whites = 4:1 Dermatomyositis & Polymyositis/Morphea Treatment Topical –Steroids –Calcipotriene ointment (Dovonex) Intralesional steroids Systemic –Hydrochloroquine –Oral calcitriole –Sulfasalazine Rheumatoid Arthritis Rheumatoid Nodules –Rare in kids w/ JIA If seen, M/C seen in (+)RF polyarthritis –M/

l. Arthritis? If you have trouble moving around or feel pain and stiffness in your body,Then it is known as arthritis.arthritis.

inflammation that occurs around the joint. Because, previous injuries, joint infections or allergies, obesity and auto-immune deficiency. http://www.homeocare.in/arthritis.htm l Types of Arthritis Osteoarthritis Rheumatoid Arthritis Gout Arthritis Septic Arthritis Juvenile Arthritis Psoriatic Arthritis Fibromyalgia Arthritis http://www.homeocare.in/arthritis.htm l Osteo Arthritis Osteoarthritis can affect both larger and the smaller joints of the body, but most affects the hands, knee, hip and facet joints/


the annual incidence of rheumatoid arthritis is approximately 3 cases per 10,000 population, and the prevalence rate is approximately 1%, increasing with age and peaking at age 35-50 years. Age Group: 40’s onwards (Juvenile cases are rare)/first monoclonal antibody drug approved by FDA and is marketed by the name of HUMIRA ( Human Monoclonal Antibody in Rheumatoid Arthritis). Structure Research Perspective 1. Better Diagnostic Test Anti MCV Antibody Test (MCV is protein belonging to citrullinated vimentin /

An Arthritis Foundation Nurses’/ Providers’ Toolkit for RA: For the Early Detection & Treatment of Rheumatoid Arthritis American Public Health Association.

Nurses’/ Providers’ Toolkit for RA: For the Early Detection & Treatment of Rheumatoid Arthritis American Public Health Association Annual Conference in Chicago Tuesday, November 3, 2015 Juvenile Arthritis Help & Support Research Advocacy Arthritis Foundation Four Pillars 1.5 million Americans 250,000 in NY, NJ and Eastern PA Impact and Damage to Joints Loss of Movement Decreased Ability to Work Increased Medical Costs /

Bone and joint infections 2 -Acute suppurative arthritis. -Tuberculosis. pathology treatmentdiagnosis.

inflamed. -the patient should be questioned and examined for evidence of gonococcal infection or drug abuse. 8 -patients with rheumatoid arthritis, and especially those on corticosteroid treatment, may develop a ( silent ) joint infection. -suspicion may be aroused by /4- Haemophilic bleed = histroy is usually conclusive, and aspiration will resolve any doubt. 5-Rheumatic fever. 6-Juvenile rheumatoid arthritis. 7-Sickle cell disease. 12 8- Gaucher s disease = in this rare condition acute joint pain and /

I2b2 Rheumatoid Arthritis DBP Defining RA in the electronic health record for future studies Elizabeth Karlson, MD Associate Professor of Medicine Harvard.

i2b2 Rheumatoid Arthritis DBP Defining RA in the electronic health record for future studies Elizabeth Karlson, MD Associate Professor of /9 codes for RA ICD-9 codes for related phenotypes –Lupus (SLE), psoriatic arthritis (PsA), juvenile inflammatory arthritis (JIA) Lab results for RA related antibodies –Rheumatoid factor (RF), anti-CCP Medications –physician entry, escripts NLP Concepts NLP queries –Rheumatoid arthritis –RA-related antibodies Anti-CCP/RF/seropositive Result coded as positive/negative –RA /

경희의대 류마티스내과 이연아 자가항체검사의 적용과 해석. Systemic Rheumatic Disease Vasculitis Rheumatoid arthritis (RA) Seronegative spondyloarthropathy -Ankylosing spondylitis.

s syndrome6255% Scleroderma3176% Poly- & dermatomyositis1952% Systemic vasculitis744% Psoriatic arthritis3818% Spondyloarthropathy1612% Juvenile chronic arthritis6966% Reactive and viral arthritis1094% Polymyalgia rheumatica1092% Osteroarthritis1785% Inflammatory bowel disease1183/El, PR3,Azuro Mod Rheumatol 19:590–599 다른 질환에서 ANCA 양성율 DiseaseFrequency of ANCA(%) Autoantigens Rheumatoid arthritis 30-70Nuclear/cytoplasmic Systemic lupus ethythematosus 20-30LF Ulcerative colitis 50-70LF, CG, BPI Sclerosing /

Etanercept (Enbrel®) for the Treatment of Ankylosing Spondylitis

progression in PsA 2003 Application for approval for AS Family of Spondyloarthropathies AS Undifferentiated Spondylo- arthropathy Juvenile Spondylo- arthropathy IBD Associated Arthritis Psoriatic Arthritis Reactive Arthritis Features of Spondyloarthropathies Sacroiliitis +/- spondylitis Enthesitis Variable involvement with peripheral arthritis Associated with uveitis No association with rheumatoid factor Strong association with the genetic marker, HLA-B27 Ankylosing Spondylitis ~350,000 patients in US/

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