1. Table 1. Clinical characteristics of subjects Mean ± s.d. n1363 Age (years)55.6 ± 14.1 Genders, % Males49.1 Females50.9 Diabetes, %44.9 Hypertension, %14.0 Measurements Urine protein, mg/day806 ± 2150 WBC, mm 3 7619 ± 3083 Hb, g/dL12.2 ± 1.9 Platelet, mm 3 260398 ± 98162 Protein, g/dL6.7 ± 2.7 Albumin, g/dL3.8 ± 0.6 Total cholesterol, mg/dL204 ± 77 LDL Cholesterol, mg/dL115 ± 43 HDL cholesterol, mg/dL44 ± 15 Triglycerides, mg/dL158 ± 209 AST, IU/L28 ± 22 ALT, IU/L27 ± 24 Fasting blood glucose, mg/dL144 ± 73 BUN, IU/L18.6 ± 10.4 Creatinine, IU/L1.16 ± 0.64 eGFR, mL/min/1.73m 2 75 ± 31 Uric acid, IU/L5.4 ± 2.0 Sodium, mEq/L140.6 ± 4.8 Potassium, mEq/L4.2 ± 0.6 Calcium, mg/dL9.1 ± 0.7 Phosphorus, mg/dL4.0 ± 3.1 Chloride, mEq/L102 ± 11 total CO 2, mEq/L26.4 ± 4.9 Total Bilirubin, mg/dL0.75 ± 0.21 Direct Bilirubin, mg/dL0.30 ± 0.09

2. eGFR ≥ 90 mL/min/1.73 m 2, n = 564 60-89 mL/min/1.73 m 2, n = 443 30-59 mL/min/1.73 m 2, n = 265 15-29 mL/min/1.73 m 2, n = 91 p-value Characteristics Age, years50.1 ± 13.857.3 ± 13.8 59.3 ± 13.759.4 ± 14.60.0001 T 1) ab, ccc Genders, % Males4648.354.356 Females5451.745.744 Diabetes, %52.845.132.829.4 Hypertension, %10.112.123.321.2 Measurements Urine protein, mg/day572 ± 1871744 ± 23661231 ± 22362050 ± 30470.0001 T 1) aa, bbc WBC, mm 3 7420 ± 31167534 ± 31127940 ± 30037909 ± 29670.252 Hb, g/dL12.5 ± 1.7 11.6 ± 1.910.8 ± 1.80.0001 T 1) aa bc Platelet, mm 3 276222 ± 103955259255 ± 92563250831 ± 96831235755 ± 879640.002 T 1) aa, b b Protein, g/dL6.7 ± 3.36.6 ± 0.96.7 ± 3.86.3 ± 0.80.447 Albumin, g/dL3.8 ± 0.73.8 ± 0.63.6 ± 0.73.5 ± 0.60.0001 T 1) aaa, bb Total cholesterol, mg/dL204 ± 93208 ± 71207 ± 87205 ± 720.215 LDL Cholesterol, mg/dL126 ± 55113 ± 44109 ± 34112 ± 400.103 HDL cholesterol, mg/dL46 ± 1645 ± 1642 ± 1440 ± 120.001 T 1) aa, bb, cc Triglycerides, mg/dL170 ± 360 151 ± 127155 ± 95180 ± 1920.657 AST, IU/L29 ± 2729 ± 2027 ± 1629 ± 380.108 ALT, IU/L28 ± 2528 ± 2324 ± 2026 ± 470.197 Fasting blood glucose, mg/dL153 ± 81142 ± 74127 ± 62127 ± 690.0001 T 1) aa, bbb BUN, IU/L12.5 ± 4.516.1 ± 5.624.3 ± 9.438.1 ± 15.50.0001 T 1) aabc Creatinine, IU/L0.71 ± 0.130.96 ± 0.161.51 ± 0.332.86 ± 0.690.0001 T 1) abcd Total Bilirubin, mg/dL0.77 ± 0.220.76 ± 0.210.72 ± 0.220.67 ± 0.210.0001 T 1) a, b b, cc Direct Bilirubin, mg/dL0.31 ± 0.090.30 ± 0.090.30 ± 0.100.28 ± 0.090.222 1) The same letters indicate non-significant difference between groups based on Turey's multiple comparison test Table 2. Age-gender standardized baseline demographics and laboratory results accordings to eGFR in the entire cohort (n= 1363)

3. 24 hour urine protein (mg/day)< 150≥ 150P value Characteristicsn = 810n = 553 Age, years55.9 ± 13.955.9 ± 14.90.642 Genders, %0.0001 Males44.755.5 Females55.344.5 Diabetes, %47.441.20.027 Hypertension, %8.721.60.0001 eGFR, %, mL/min/1.73m 2 0.0001 ≥ 9035.823.1 60-8944.431.1 30-5916.631.5 15-293.214.3 Measurements WBC, mm 3 7296 ± 29408044 ± 32160.0001 Hb, g/dL12.5 ± 1.711.8 ± 1.90.0001 Platelet, mm 3 257821 ± 93576263793 ± 1038960.315 Protein, g/dL6.8 ± 1.66.5 ± 3.70.097 Albumin, g/dL4.0 ± 0.43.5 ± 0.70.0001 Total cholesterol, mg/dL194 ± 49219 ±1030.0001 LDL Cholesterol, mg/dL115 ± 37115 ± 490.952 HDL cholesterol, mg/dL45 ± 1543 ± 160.023 Triglycerides, mg/dL148 ± 151174 ± 2720.037 AST, IU/L27 ± 2029 ± 250.139 ALT, IU/L27 ± 2127 ± 280.898 BUN, IU/L16.3 ± 7.921.7 ± 12.40.0001 Creatinine, IU/L0.99 ± 0.411.39 ± 0.790.0001 Total Bilirubin, mg/dL0.78 ± 0.200.71 ± 0.220.0001 Direct Bilirubin, mg/dL0.30 ± 0.090.29 ± 0.090.003 Table 3. Age-gender standardized baseline demographics and laboratory results accordings to 24 urine protein excretion in the entire cohort (n= 1363)

4. Fasting blood glucose, mg/dL< 126≥ 126P value Characteristics Age, years53.9 ± 14.657.7 ± 13.10.0001 Genders, %0.414 Males48.150.3 Females51.949.7 eGFR, %, mL/min/1.73m 2 0.0001 ≥ 9027.534.1 60-8936.341.9 30-5926.618.2 15-299.65.8 Measurements 24 hour urine protein, mg/day913 ± 2350676 ± 18700.038 WBC, mm 3 7368 ± 29427965 ± 32390.001 Hb, g/dL12.0 ± 1.812.3 ± 1.80.003 Platelet, mm 3 258479 ± 97902263037 ± 985600.438 Protein, g/dL6.7 ± 3.26.6 ± 1.90.639 Albumin, g/dL3.7 ±0.73.8 ± 0.50.046 Total cholesterol, mg/dL207 ± 78201 ± 750.211 LDL Cholesterol, mg/dL114 ± 47115 ± 380.877 HDL cholesterol, mg/dL46 ± 1642 ± 140.0001 Triglycerides, mg/dL140 ± 97179 ± 2860.002 AST, IU/L28 ± 2028 ± 250.861 ALT, IU/L24 ± 1930 ± 290.0001 BUN, IU/L19.0 ± 11.018.1 ± 9.60.16 Creatinine, IU/L1.24 ± 0.691.06 ± 0.550.0001 Total Bilirubin, mg/dL0.75 ± 0.210.76 ± 0.210.499 Direct Bilirubin, mg/dL0.30 ± 0.090.30 ± 0.080.705 eGFR, mL/min/1.73m 2 71 ± 3180 ± 300.0001 Table 4. Age-gender standardized baseline demographics and laboratory results accordings to fasting blood glucose (n= 1363)