1. Maryakhina V.S., Gun’kov V.V. Orenburg state university, Russia v.s.maryakhina@gmail.com Saratov fall meeting- 2015

2. Exemplary fluorescence images of one animal after injection 2 μ mol/kg TSC (tetrasulfonated carbocyanine) intravenously into F9-teratocarcinoma bearing mice Christin Perlitz, et all //Journal of Fluorescence, Vol. 15, No. 3, 2005 Saratov fall meeting- 2015

3. Enzyme Cells Photosensitizer monomer Enzyme dimer Photosensitizer monomer fixed moving Saratov fall meeting- 2015

4. Maryakhina V.S., Gunkov V.V. Computer research and modeling, 2013 Dynamics of bengal rose fluorescence in model solution of collagenase with mammary cells Saratov fall meeting- 2015

5. Concentration changes of photosensitizer molecules at immobilization process received from two models Saratov fall meeting- 2015

6. Maryakhina V.S., Letuta S.N.// Laser physics.- 2014.- V. 24.- p. 035601 eosine bengal rose 1- 10 -4 М 2- 10 -3 М bengal roseeosine Saratov fall meeting- 2015

7. Comparison of experimental and theoretical results The normalized experimental (1,2) and theoretical (3,4) fluorescence spectra of erythrosine in collagenase solution 0.1 mkg/ml after addition of dye aliquot with initial concentration: 1,3- 0.1 m М ; 2,4- 1 m М. Maryakhina V.S., Gun’kov V.V. Computer research and modeling.- 2013.- V.5.- №5.- p. 835-843 Saratov fall meeting- 2015

8. Fluorescence intensivity dynamics at 560 nm Enzyme 560 nm 545 nm C enzyme = 0.5 mg/ml Maryakhina V.S., Gun’kov V.V. Computer research and modeling.- 2013.- V.5.- №5.- p. 835-843 C enzyme = 0.1 mg/ml 0.5 mg/ml Saratov fall meeting- 2015

10. For biological liquid flow (blood, for example) - differential equation of convective diffusion (moving medium) a few phases w w, w p, w cell - rate of water, peptide and cell phases assumptions - w w = w p = w cell - movable coordinates x=r+wt Maryakhina V.S., Gun’kov V.V.// JIOHS, 2016, V.9 (4) Saratov fall meeting- 2015

11. Initial and bordering conditions d vessel = 0.5 cm R i - average peptides / cells size, nm; R- size of the injected compound molecule, nm. 0.2 cPz0.4 cPz0.6 cPz0.8 cPz1 cPz D p ·10 -12, m 2 /s2.81.40.90.70.56 D cell ·10 -15, m 2 /s4.52.21.51.10.9 D w ·10 -9, m 2 /s0.50.250.160.130.1 0.2 cPz0.4 cPz0.6 cPz0.8 cPz1 cPz k 1 ·10 -20, m 3 /s3.651.831.210.910.73 k 2 ·10 -17, m 3 /s1.650.830.540.410.33 plasma is 60 % from blood volume; different cell types are the rest 40 % while peptide molecules are 8 % in plasma. Saratov fall meeting- 2015

12. The kinetic curves of the injected compound concentrations in water, cells and peptide phases for different cell concentrations C cell (from 30 % to 50 % ) Maryakhina V.S., Gun’kov V.V.// Journal of innovative optical health sciences, 2016, V.9 (4) Saratov fall meeting- 2015

13. Dynamics of fluorescence spectra change of bengal rose. λex= 515 nm. C cell (x,0)=0.4 The experimental fluorescence spectra of bengal rose in: 1- buffer solution, 2- in blood serum albumin, 3- cancer mammary cells suspension. Saratov fall meeting- 2015

14. Changes of bengal rose fluorescence spectrum intensity at 560, 590 and 580 nm to time for different cell concentrations Saratov fall meeting- 2015

15. The experimental setup for investigation of distribution of the injected compound in blood flow - pump - pressure sensor This experimental setup was created in our laboratory. It is a system of polymer tubes in which model liquid circulate. The first experiments will be soon. Saratov fall meeting- 2015

16. This work is partially supported by grant of RFBR №14-01-31081 mol_a and president fellowship № SP-273.2015.4 for young scientists