1. The authors have no financial interest in the subject matter of this poster. Cesar Bernilla MD, Maria A. Henriquez MD, Luis Izquierdo MD Instituto de ojos OFTALMOSALUD. Lima – Peru

2.  To evaluate high order aberrometric outcomes 12 months after corneal collagen cross-linking (CXL) in eyes with keratoconus. HIGH ORDER ABERRATIONS AFTER CORNEAL COLLAGEN CROSSLINKING

3.  Forty eyes of thirty four patients were included in this prospective, non randomized and single- center clinical study, using scheimplug analyzer Pentacam® version 1.16r63. HIGH ORDER ABERRATIONS AFTER CORNEAL COLLAGEN CROSSLINKING

4.  Trefoil and coma mean baseline aberrations decrease from -0.0548 +/-0.3562 µm to -0.1963 +/-0.5421µm (p≤0.05) and from -1.6999 +/-1.1862µm to -23.3783 +/- 139.2510µm (p≤0.05) respectively. HIGH ORDER ABERRATIONS AFTER CORNEAL COLLAGEN CROSSLINKING

5.  Total aberrometic coeficient mean baseline were 1.750 +/- 0.4819µm, increasing to 1.893 +/- 0.6293µm at 12 month postoperative. That difference was not significant (p<0.05). HIGH ORDER ABERRATIONS AFTER CORNEAL COLLAGEN CROSSLINKING

6.  Astigmatic and spherical aberrations mean baseline increase from -0.0282 +/-0.4899µm to 0.0593 +/-0.5281µm (p≤0.05) and from 0.3530 +/-0.7344µm to 0.6033 +/-1.082µm (p≤0.05) respectively. HIGH ORDER ABERRATIONS AFTER CORNEAL COLLAGEN CROSSLINKING

7. ORDERABERRATION PRE OPERATIVE MEAN (µm) POST OPERATIVE MEAN (µm) Mean aberration coeficient1.75 (±0.48198) 1.8925 (± 0.62936 ) 3rdComa-1.6999 (±1.18623) -23.3783 ( ± 139.25109 ) 3rdTrefoil-0.0548 (±0.35627) -0.1963 ( ± 0.51242 ) 4thHigh order astigmatism-0.0491 (±0.48198) 0.1524 ( ± 0.77456 ) 4thTetrafoil-0.0294(±0.60129) -0.0543 ( ± 0.52224 ) 4thSpherical Aberration0.3513 (±0.73449) 0.6033 ( ± 1.08027 ) 5thHigh order coma0.0488 (±0.28599) -0.0643 ( ± 0.38893 ) 5thHigh order trefoil-0.0035 (±0.20314) -0.061 ( ± 0.23362 ) 5thPentafoil-0.0121 (±0.19826) -0.0234 ( ± 0.40602 ) Table 1. Summary of high order aberrations mean before and 12 months after corneal croslinking treatment.

8. ORDERABERRATIONMEAN (µm) STANDARD DEVIATION SIGNIFICANCE LEVEL Mean aberration coeficient-0.14250.595660.138 3rdComa21.67838139.300350.039 3rdTrefoil0.141480.54780.045 4thHigh order astigmatism-0.201430.543350.108 4thTetrafoil0.024930.526940.776 4thSpherical Aberration-0.2520.896430.083 5thHigh order coma0.1130.377760.066 5thHigh order trefoil0.57450.268620.184 5thPentafoil0.01130.414960.864 Table 2. High order aberrations mean variations 12th months after corneal croslinking treatment. Coma and trefoil aberration reduction was statistically significant (p<0.05).

9. Fig 1. Coma aberration reduction on a patient treated with Corneal Crosslinking

10.  There was a reduction on coma and trefoil aberrations in patients with keratoconus undergoing crosslinking Pentacam corneal evaluated 12 months after procedure. However there was no statistically significant variation in high order aberrations coeficient.