1. Cryptococcus choroiditis
André Luiz Land Curi
National Institute of Infectious Diseases – INI/IPEC – Fiocruz
Brazil

2. General and Ocular History
35 year old man
HIV +, CD4+: 5 cells/mm3 ,
viral load >
Admitted due to Pneumocystis carinii pneumonia
Good recovery after treatment with Bactrim®
Visual loss in both eyes
Vomiting , weight loss, headache

3. Ocular Examination at first presentation
VA : 6/18 OD / 6/60 OS
No anterior chamber cells
Normal intraocular pressure
No vitreal cells
Fundus: OU: multiple, yellowish, subretinal infiltrates
FLA: hypofluorescence in early phase and hyperfluorescence in late phase corresponding to yellowish lesions

6. Diagnostics
Admitted again
Lumbar puncture
Cryptococcus neoformans

7. Therapy
IV Amphotericin B
1 mg/kg/d for 6 weeks

8. Final Visit
VA : 6/9 OD 6/6 OS

9. Conclusion
Multifocal choroiditis is an uncommon manifestation in disseminated Cyrptococcus neoformans infection
It usually shows good response to specific therapy
The diagnosis is based on latex test, direct examination and culture body fluids