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Clickers: Which one of the following reactions would actually work as written?

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Presentation on theme: "Clickers: Which one of the following reactions would actually work as written?"— Presentation transcript:

1 Clickers: Which one of the following reactions would actually work as written?

2 Aldol condensation of ketone driven to completion by elimination (high temp). Clickers: Which one of the following reactions would actually work as written?

3 Clickers: What product would be isolated after workup?

4 Equilibrium conditions, 5- membered ring therefore get rapid elimination to thermodynamically-favoured enone isomer Clickers: What product would be isolated after workup?

5 Clickers: Which of the following would least likely form a nucleophilic carbanion on treatment with a base?

6 O-H 15 - 17; C-H approx 50! Clickers: Which of the following would least likely form a nucleophilic carbanion on treatment with a base? Approx. pKa 19 - 20 25 24 - 25 10 - 11


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