1. VII. Genetic Disorders A. Turner’s Syndrome – females w/ only 1 X chr. (XO) Nondisjunction 1 out of 3,000 infertile Short stature Webbed neck https://www.youtube.com/watch?v=82BNi6ps9X8

2. B. Klinefelter’s Syndrome – males w/ an extra sex chromo. (XXY) - Nondisjunction - 1 out of 2,000 births - infertile - lower IQ https://www.youtube.com/watch?v=c9ne4Cwy9T4

3. C. Down’s Syndrome - (Trisomy 21) – extra 21 st chromo. Nondisjunction mental retardation, muscle weakness, heart defects, short stature 1 in 1,000 when mom is age 15-34, 1 in 400 at age 35 https://www.youtube.com/watch?v=Ju-q4OnBtNU

4. D. Cri du chat - deletion of a segment of DNA in chromo 5. - affects development of larynx - cry sounds like a cat - mental retardation - 1 in 50,000 https://www.youtube.com/watch?v=La1D4cNQ5kQ

5. E. Cystic fibrosis – excess mucus clogs lungs & digestive system autosomal recessive 30,000 people in US Average age 37 https://www.youtube.com/watch?v=qV30ZynAJfw

6. F. Sickle Cell Anemia – red blood cells are distorted sickle shape; unable to bind oxygen properly autosomal recessive 1 in 5,000 (1 in 500) https://www.youtube.com/watch?v=qe59ar-GZmg

7. G. Huntington’s Disease – deterioration of brain tissue in middle age autosomal dominant 10-30 yrs of life after diagnosis https://www.youtube.com/watch?v=HBLrY_nXU_U

8. H. Edward’s syndrome (Trisomy 18 )- extra 18 th chromosome Most babies die at death < 10% will live up to 1 year https://www.youtube.com/watch?v=th6Njr-qkq0