1. Neurotransmitter Release

5. High voltage Low voltage

12. Mechanism of Exocytosis synapsins anchor vesicle to cytoskeleton  Ca 2+ influx  activates Ca 2+ /calmodulin dependent kinase (CaMK)  phosporylaton of synapsin I  release of vesicle from cytoskeleton  move to active zone  Rab3A binds to vesicle  hydrolysis of Rab GTP to GDP + PO 4  targeted to docking site at active zone  interaction of v-SNARES and t-SNARES  docking and membrane fusion  exocytosis and release of Rab into cytoplasm t-SNARES = syntaxin and SNAP25 v-SNARE = synaptobrevin (VAMP)

15. http://www.youtube.com /watch?v=eRslV6lrVxY

17. http://www.youtube.com/ watch?v=K7yku3sa4Y8