1. And Loeys-Dietz Syndrome
TGF BETA
And Loeys-Dietz Syndrome

2. DIMERIZE P
Serine Threonine Kinase
p15
p21

3. TUMOR SURPRESSOR GENES
p15 and p21
Cyclin B + CDK1
Cyclin D + CDK4
Cyclin E + CDK2
Cyclin A + CDK2
P15+ CDK4
P21+ CDK4
P21+ CDK2
P21 + CDK1
P15 can bind to CDK4
P21 can bind to CDK4
P21 can bind to CDK2
P21 can bind to CDK1
TUMOR SURPRESSOR GENES

4. Loeys-Dietz Syndrome Symptoms Widely spaced eyes Wide or split uvula
Abnormal twisting or arteries.
 Aneurysms at the aortic root

5. FOUR TYPES
Mutations in
1. TGFBR1
2. TGFBR2
3. TGFB2
4. SMAD3

6. AORTA
P15
P21