1. 牙放 seminar 第一組 2.1.1-1 Periapical granuloma 2.1.2-4 Nasopalatine duct cyst 2.1.1-2 Radicular cyst 2.1.2-5 Eosinophilic granuloma 2.1.1-3 Surgical defect 2.2-1 Dental follicle 2.1.1-4 Periapical abscess 2.2-2 Pericoronitis 2.1.1-5 Osteomyelitis 2.2-3 Paradental cyst 2.1.2-1 Cementoma 2.2-4 Dentigerous cyst 2.1.2-2 Periodontitis 2.2-5 Muralameloblastoma 2.1.2-3 Trauma bone cyst 2.2-6 Adenomatoid Odontogenic Tumor

2. these is well-defined oval or round radiolucences without corticated outline located at mesial root of the tooth 36 extending to the furcation area, measuring approximately 1x1cm in dimension. PDL widening of the mesial root of 36 is also noted. 2.1.1-1

3. Periapical Granuloma Clinical features: asymptomatic pain and sensitivity can develop 病理特徵 : Periapical Granuloma 的 granulation tissue 是由三個東西組成 : - 發炎組織 : lymphocyte 、 PMN 、 plasma cell - 血管 -Fibrous tissue : 在發炎組織和血管的外面 看不到 epithelium lining, 沒有表皮包圍, 只有 granulation tissue 。

4. 2.1.1-2 there is a well-defined unilocular round shaped periapical radiolucence with a corticated margin over the tooth #23 between the adjacent teeth, extending from the distal aspect 22 to mesial aspect of 23, measuring 2cm in diameter. The radiopaque border is continuous with the lamina dura of the associated tooth.

5. Radicular cyst 外圍是 non-keratinized stratified squamous epithelium 有 rete process 增生 hyaline body foamy cells fibrous wall 會有 heavy deposits of cholesterol crystals

6. Periapical granuloma 和 Radicular cyst 的不同點 : periapical granuloma 比 cyst 常見 Radicular cyst 比較常發 生在 upper jaw bone. Radicular cyst X-ray 片上 可以看到完整的 lamina dura Granuloma 沒有治療就會 演發成 radicular cyst Radicular cyst 發生在 nonvital tooth

7. 2.1.1-3

8. Surgical Defect 病灶不會擴大，所以應該也不會對其他牙齒或者組織造 成任何影響 這是根尖切除術之後，手術的地方骨頭組織再生失敗造 成的 骨頭組織被 fibrous tissue 所取代，很常發生在 apical 的 地方 在 X 光片下，是 well-defined, radiolucence 的 牙齒自己本身也不會有任何症狀，除非是照 X 光片，否 則是不會被察覺的 根尖切除術的術後結果；有可能會 pain, hemorrhage, swelling, ecchymosis, paresthesia, maxillary sinus perforation 。

9. There is ill-defined unilocular shaped radiolucence without a corticated margin on periapcial area of tooth 14, and with a periodontal pocket on the distal side. This maybe a combination syndrome of both endo. and perio. with progression, the abscess may extend through the medullary spaces away from the apical area resulting in osteomyelitis, or it may perforate the cortex and spread diffusely through the overlying soft tissue 2.1.1-4

10. Apical absess arise as the initial periapical pathosis or from an acute exacerbation (phoenix abscess) of a chronic periapical inflammatory lesion. In the early stage, the periapical periodontal ligament fibers may exhibit acute inflammation but no frank abscess formation. best termed acute apical periodontitis.

11. Clinical Features painful tender swelling of varying size and position tenderness to pressure in buccal sulcus fever and malaise erythema and possibly draining sinus, intraoral or extra- oral unresponsive to thermal and electrical stimuli positive percussion test

12. Differential diagnosis Periapical granuloma: 根尖處牙周膜肥厚 (raiolucency) Well-defined with a corticated radiopaque line or zone of sclerotic bone. Radicular cyst: 與 periapical granuloma 類似，無法以 radiolucency 區別。 Osteomyelitis: poor-defined “moth-eaten” radiolucency

13. 2.1.1-5

14. Osteomyelitis, periapical Osteomyelitis 就是骨髓的發炎 好發位置在 posterior body of mandible ，上顎是很少見的 其重要的特徵就是會有 sequestra 的產生。 分為 acute 以及 chronic

15. 2.1.2-1 There is a well-defined monolocular round shaped radiolucence without a corticated margin at the apical area of both mandibular central incisors(tooth24,25)extending from the mesial aspect of tooth 26 to the periapical area of tooth 24,measuring approximately 1 cm in diameter.the adjacent teeth are typically vital and not resorbed with an intact periapical ligament space.

16. Cemetoma, periapical cemento-osseous dysplasia, stage 1 Middle-aged adults (typically black women ) Monolocular, often multiple Early stage : radiolucent,not corticated Intermediate stage : radiopacity within the apical radiolucencies Late stage : densely radiopaque but surrounded by a thin radiolucent line Traumatic ( solitary ) bone cyst Radicular cyst Periapical granuloma

17. There is a continuous irregular radiolucence with a poor defined margin along the apical area of the right maxillary posterior teeth (tooth 2,3,4and 5),and a well-defined round shaped radiolucence without a corticated margin at the periapical area of tooth 4,with a superior margin at the apex os the root and a inferior margin near the midle one-third of the root,measuring approximately 1 cm in diameter.Severe bone destruction can be observed around the roots of the teeth. 2.1.2-2

18. Periodontitis Eosinophilic granuloma Traumatic (solitary ) bone cyst Periapical granuloma Radicular cyst

19. There is a well-defined monolocular scalloped-shape radiolucence without a cortical margin between the root of the 35 and 37 extending from the distal of 35 to the root tip of 37 squeezing along the root outline ， measuring approximately 4 × 2 cm in diameter. The involved teeth from 35 to 37 are still alive with lamina dura. 2.1.2-3

20. Trauma bone cyst well-defined (corticated) radiolucence asymptomatic under 20 years old 60% male common in the mandibular premolar and molar areas margin along the root ， not push vital teeth scallop(several teeth) empty or fluid filled cavity

21. lateral periodontal cyst Same-- male prefer asymptomatic corticated round radiolucency along the lateral root surface in alveolar bone Different-- old ages often in mandibular premolar-canine-lateral incicor area(rarely in molars) some are botryoid round lucency(botryoid odontogenic cyst)

22. aneurysmal bone cyst(ABC) same— well defined unilocular radiolucency different— large blood-filled spaces often described as "soap bubble" teeth moved and roots resorption

23. odontogenic keratocyst(OKC) Same— scalloping asymptomatic different– wide age range multiple(about10%) teeth moved and roots resorption

24. glangular odontogenetic cyst(GOC) same— painless scalloping different— usually anterior mandible middle aged teeth moved and roots resorption

25. There is a well-defined monolocular round shaped radiolucence with a corticated margin at midline of anterior maxilla,measuring approximately 2x4 cm in diameter.Upper central incisors are separated apart. 2.1.2-4

26. Nasopalatine duct cyst (Incisive Canal Cyst) 40~60 years old ; ♂＞♀ site: midline, anterior maxilla Unilocular, round or oval, well- defined, well corticated (unless infected) It may cause palatal expansions smooth cortical border arises from epithelial remnants of the nasopalatine duct

27. usually present in the midline of the anterior maxilla near the incisive foramen many are inflamed pain, pressure, drainage and swelling can occur

28. Differential Diagnosis : periapical granuloma radicular cyst

29. There is a round-shaped monocular radiolucence without corticated margin between the edentulous area,measurely approximately 3X5 cm in diameter,extending from tooth44 and tooth47, Destruction of the periodontal bone (loose teeth)without otherwise affecting the teeth (e.g. root resorption). 2.1.2-5

30. Eosinophilic Granuloma Benign proliferation of Langerhans cells. Usually adolescents and young adults. Localized or multiple lesions. In the jaws, more than 75% in mandible. Round, monolocular, not corticated. Destruction of the periodontal bone (loose teeth)without otherwise affecting the teeth

31. Periodontitis Radicular cyst Squamous cell carcinoma Metastatic tumors (ill defined) Malignant salivary gland tumors

32. 2.2-1 ＊ There is a well-defined, unilocular, round-shaped radiolucence with a well- corticated margin above tooth22,surrouing crown of an impacted tooth, extending from distal aspect of tooth 21 to mesial aspect of tooth 24 and from the half part of the tooth 22’s root to alveolar bone above tooth 22. The height of the radiolucence is about to its width.

33. Dental follicle ※ dentigerous cyst ： 同：組成都有 reduced enamel epithelium 異：後者的 reduced enamel epithelium 有異常增生的 現象， cyst 會聚積液體不斷擴大。 ＊ Dentigerous cyst 有構成 cyst 的三個要素，是一個病理 上 的構造； dental follicle 只是牙齒發育時期的正常組織。 在牙齒成長時期晚期 (cap stage+bell stage) 的支持組織； 牙齒萌發後轉變為 periodontium 上的纖維組織。

34. Dental follicle ※ Impaction of upper canine-- 全部牙齒發生率 No.1 ※ Upper canine 阻生牙發生原因： 1. 牙弓空間不足，兩側恆齒較早萌發。 2. Lat. Incisor 的牙根偏歪。 3. 乳齒的 canine 因蛀牙太早離開牙弓。 4. 牙胚位置不正確 5. 有 dentigerous cyst 或是 tumor 阻礙萌發

35. 2.2-2 This radiograph is part of a panoramic one. There is a radiolucence locating at distal aspect of tooth 38, extending from distal of the tooth 38’s crown to the ramus of mandibular bone, measuring about 1 cm. Its height is approximately the length of tooth 38’s crown. It’s well-defined, surrouned by nearby soft tissue (gingiva) and the crown of tooth 38.

36. Pericoronitis 口病特徵 : 位在左側第三臼齒的遠心面外側 成因是因為下顎智齒在長成的時候牙弓已經 沒有太多的空間，牙冠生長受到上方牙齦肉的 阻礙 reduced enamelepithelium 沒有辦法與 oral mucosa 結合形成 junctional epithelium ，使牙 齦肉與牙齒無法緊密結合

37. Pericoronitis 口病特徵 : 智齒的清潔不夠徹底的話，就會導致該處牙齦 發炎，並且引起劇烈疼痛 病人有咬合困難的問題 。嚴重一點的話，發 炎的牙齦內有 pus 的產生，引起不適的味覺體驗。 引起的痛覺，可能會轉移到喉嚨，耳朵，口底 等處

38. Differential diagnosis: Paradental cyst: 同 : 同樣是發生在第三下顎臼齒的遠心面外 側或 facial aspect ，與部份阻生的牙齒有 關 。 異 : 它所形成的是 cyst ，要形成 cyst 有 3 要 素，分別是 cavity ， epithelium ， wall 。 而 pericoronitis 並非 cyst 。

39. Differential diagnosis: Dentigerous (follicular) cyst : 同 : 與阻生牙的機率成正比，也易發生於第 三臼齒 。 異 : 是一種 cyst ，要形成 cyst 有 3 要素，分別 是 cavity ， epithelium ， wall 。鈣化好的 牙冠 (crown ) ，被 cyst 給包住 。發生的 地點除智齒外，也有可能發生在 upper canine 。

40. 治療 : 局限性的 ：用溫的鹽水來漱口，並時時確 保沒有食物在 gingival flap 內。 急性的：發生了嚴重的疼痛及發炎，就要 採取手術的方式，將智齒拔除或是 切掉 gingival flap 。

41. There is a small well-defined unilocular oval shaped radiolucence with corticated margin in the distal of the tooth 48 extending from distal cervical margin of the tooth 48 down to superior wall of inferior alveolar canal and up to the 1/4 ramus, measured approximately 1x1 cm in diameter. 2.2-3

42. Paradentalcyst 病理特徵 好發位置： mandibular third molar 的 lateral root surface 、靠近 cervical margin 致病原因： uncertain. involved by pericoronitis (usually lower 3rd molar).

43. There is a well-defined unilocular oval shaped circumcoronal radiolucence with a corticated border over the submerged tooth 48 extending from retromolar area down to the mandibular angle, measuring approximately 1 cm in diameter. 2.2-4

44. Features of Dentigerous Cyst Most common odontogenic cyst, next to radicular cyst. Etiology X-ray Site P’t ages: usually adolescents, 20~40 years old. Eruption cyst Effects on adjacent tooth Treatment Progonosis Ameloblastic change (neoplastic transformation)

45. Differential diagnosis Mural ameloblastoma

46. Adenomatoid Odontogenic Tumor (AOT) Differential diagnosis

47. Ameloblastic fibroma Differential diagnosis

48. Paradental cyst Differential diagnosis

49. There is a well-defined unilocular irregular shaped pericoronal radiolucence without corticated margin associated with an unerupted 38 tooth extending from distal aspect of the unerupted tooth 37 up to approximately 2/3 left ramus and from superior border of ramus down to left mandibular angle, measured approximately 3x3 cm in diameter. 2.2-5

50. Muralameloblastoma 病理特徵 ‧ arises most commonly from a dentigerous cyst ‧ most common site: Mandible posterior region ‧ cause root resorption of the adjacent teeth ‧屬於 unicystic ameloblastoma 其中一種 tumor 會侵入 cystic wall(fibrous tissue) ，往外增 生，癒後最差

51. Ameloblastoma 臨床上 ameloblastoma 分成三大類： conventional / multicystic type ( 86% ) unicystic type ( 13% ) - luminal ameloblastoma - intraluminal ameloblastoma - mural (wall) ameloblastoma Peripheral (extraosseous) type ( 1% )

52. Ameloblastoma unicystic ameloblastoma 和 conventional ameloblastoma 的比較： conventional ameloblastomaUnicystic ameloblastoma Case 比例 about 86% of all casesabout 13% of all cases Shapemultilocular radiolucenceUnicystic radiolucence 發生位置 20% in maxilla 80% in mandible 56% in mandibular molar, ramus region 90% in ramus region 發生年齡 40 、 50 歲的時候診斷出來，發生 的平均年齡大約是 39 、 40 歲左右 18-20 歲 recurrent rate 50-90%10-20%

53. 2.2-6 There is a well-defined unilocular oval shaped radiolucence with a corticated margin. It extend from apex of tooth 21 to apex of tooth 25 and from 3mm below alveolar crest to nasal spine level,measuring approximately 3 x 3 cm in diameter. It causes tooth 21 and tooth 23 unerupted, tooth 21 malposition (root slants to mesisal) and tooth 24 slanted to distal.

55. Adenomatoid Odontogenic Tumor (AOT) 良性腫瘤. 發生在年輕人.(70% 2nd decade) 好發區域：上顎前牙 ( 側門齒－ 犬齒－第一小臼齒 ) 經常包住一個沒有萌發的牙齒 生長緩慢，無痛，長太大會使 骨頭鼓起使臉不對稱 2/3 的病例在裡面會有 Radiopacities 發生 治療：手術切除

56. Difference Disease Dentigerous cyst Dental follicle Mural Ameloblastoma Full radiolucence 的話只能用採樣確認

57. THE END