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Lehninger Principles of Biochemistry

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1 Lehninger Principles of Biochemistry
David L. Nelson and Michael M. Cox Lehninger Principles of Biochemistry Fourth Edition Chapter 11: Biological Membranes and Transport Copyright © 2004 by W. H. Freeman & Company

2 Chapter Outline The composition and architecture of membranes
Membrane dynamics Solute transport across membranes

3 The composition and architecture of membranes
Proteins Polar lipids Carbohydrates (glycoproteins, glycolipids)

4 Different types of membrane have different protein/lipid proportions

5 Membrane lipids varies for different organelles from the same cell

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8 Types of integral proteins

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11 Fluidity of biological membranes
Sat’d FA Unsat’d FA Cholesterol Temperature Decide the membrane fluidity.

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14 FRAP (flourescence recovery after photobleaching)

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19 Type of transporter Carrier (carrier, pump) : binding site binds to ligand; can go against concentration gradient Channel : must from high  low, gate is present

20 Type of transport system
Simple diffusion Facilitated diffusion Active transport Primary: need pump, energy from ATP or light Secondary: need carrier, energy from ion gradient Ion channel: from high  low

21 Need protein carrier? NO YES Simple diffusion Saturable with substrate? NO YES Ion channels Produces concentration gradient? NO YES Facilitated transport Energy source? ATP, light, substrate oxidation Ion gradient Primary active transport Secondary active transport

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25 GLUT1

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33 P-type ATPase Na+-K+ ATPase Ca2+ ATPase
Maintaining the differences in the ionic composition of the cytosol and the extracellular medium

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35 ABC transports

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37 Aquaporins

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