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Meiosis and Sexual Life Cycles. Life is distinguished by the ability of organisms to reproduce their own kind. Genetics: the scientific study of heredity.

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Presentation on theme: "Meiosis and Sexual Life Cycles. Life is distinguished by the ability of organisms to reproduce their own kind. Genetics: the scientific study of heredity."— Presentation transcript:

1 Meiosis and Sexual Life Cycles

2 Life is distinguished by the ability of organisms to reproduce their own kind. Genetics: the scientific study of heredity and variation. Heredity: the transmission of traits from one generation to the next. Variation: offspring differ in appearance from parents and siblings.

3  In a literal sense, children do not inherit particular physical traits from their parents.  It is genes that are actually inherited.

4  Genes: segments of DNA that are the units of heredity.  Each gene has a specific locus on a certain chromosome.  One set of chromosomes is inherited from each parent.  Reproductive cells called gametes (sperm and eggs) unite, passing genes to the next generation.

5  In asexual reproduction, one parent produces genetically identical offspring by mitosis.  In sexual reproduction, two parents give rise to offspring that have unique combinations of genes inherited from the two parents. Parent 0.5 mm Bud

6 Each human somatic cell (any cell other than a gamete) has 46 chromosomes arranged in pairs.  The two chromosomes in each pair are called homologous chromosomes, or homologues.  Both chromosomes in a pair carry genes controlling the same inherited characteristics.

7 5 µm Pair of homologous chromosomes Sister chromatids Centromere A karyotype is an ordered display of the pairs of chromosomes from a cell.

8  Autosomes: the chromosomes that do not determine sex.  A cell with a single set is called haploid (n).  A cell with two sets is called diploid (2n).  Each pair of homologous chromosomes includes one chromosome from each parent.  For humans, the haploid number is 23 and the diploid number is 46. (n = 23, 2n = 46)

9  In humans, the sex chromosomes are called X and Y.  Human females have a homologous pair of X chromosomes (XX).  Human males have one X and one Y chromosome (XY).

10  In a cell in which DNA synthesis has occurred, each chromosome is replicated.  Each replicated chromosome consists of two identical sister chromatids.

11 Key Maternal set of chromosomes (n = 3) 2n = 6 Paternal set of chromosomes (n = 3) Two sister chromatids of one replicated chromosomes Two nonsister chromatids in a homologous pair Pair of homologous chromosomes (one from each set) Centromere

12  Gametes are haploid cells, containing only one set of chromosomes.  Each set of 23 consists of 22 autosomes and a single sex chromosome.  In an unfertilized egg (ovum), the sex chromosome is X.  In a sperm cell, the sex chromosome may be either X or Y.

13  At sexual maturity, the ovaries and testes produce haploid gametes.  Gametes are the only types of human cells produced by meiosis, rather than mitosis.  Meiosis results in one set of chromosomes in each gamete.  Fertilization, the fusing of gametes, restores the diploid condition, forming a zygote.  The diploid zygote develops into an adult.

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15  The alternation of meiosis and fertilization is common to all organisms that reproduce sexually.  The three main types of sexual life cycles differ in the timing of meiosis and fertilization.  Depending on the type of life cycle, either haploid or diploid cells can divide by mitosis.  However, only diploid cells can undergo meiosis.  In all three life cycles, chromosome halving and doubling contribute to genetic variation in offspring.

16 Key Haploid Diploid Gametes n Diploid multicellular organism (sporophyte) Mitosis Diploid multicellular organism FERTILIZATION MEIOSIS Zygote n n 2n2n 2n2n Animals Plants and some algae Most fungi and some protists n n n n n n n n n n FERTILIZATION MEIOSIS Gametes Zygote Mitosis 2n2n 2n2n 2n2n Spores Haploid multicellular organism (gametophyte) Haploid multicellular organism

17  Like mitosis, meiosis is preceded by the replication of chromosomes.  Meiosis takes place in two sets of cell divisions, called meiosis I and meiosis II.  The two cell divisions result in four daughter cells, rather than the two daughter cells in mitosis.  Each daughter cell has only half as many chromosomes as the parent cell.

18  Meiosis I is preceded by interphase, in which chromosomes are replicated to form sister chromatids.  The sister chromatids are genetically identical and joined at the centromere.  The single centrosome replicates, forming two centrosomes.

19 The Stages of Meiosis  In the first cell division (meiosis I), homologous chromosomes separate.  Meiosis I results in two haploid daughter cells with replicated chromosomes.  In the second cell division (meiosis II), sister chromatids separate.  Meiosis II results in four haploid daughter cells with unreplicated chromosomes. Homologous pair of chromosomes in diploid parent cell Interphase Homologous pair of replicated chromosomes Chromosomes replicate Meiosis I Diploid cell with replicated chromosomes Sister chromatids Meiosis II Homologous chromosomes separate Sister chromatids separate Haploid cells with replicated chromosomes Haploid cells with unreplicated chromosomes

20 Mitosis conserves the number of chromosome sets, producing cells that are genetically identical to the parent cell.  Meiosis reduces the number of chromosomes sets from two (diploid) to one (haploid), producing cells that differ genetically from each other and from the parent cell.  The mechanism for separating sister chromatids is virtually identical in meiosis II and mitosis.

21 Propase Duplicated chromosome (two sister chromatids) Chromosome replication 2n = 6 Parent cell (before chromosome replication) Chromosome replication MITOSISMEIOSIS Chiasma (site of crossing over) MEIOSIS I Prophase I Tetrad formed by synapsis of homologous chromosomes Tetrads positioned at the metaphase plate Metaphase I Chromosomes positioned at the metaphase plate Metaphase Anaphase Telophase Homologues separate during anaphase I; sister chromatids remain together Sister chromatids separate during anaphase Daughter cells of meiosis I Haploid n = 3 Anaphase I Telophase I MEIOSIS II Daughter cells of mitosis 2n2n 2n2n n Sister chromatids separate during anaphase II n nn Daughter cells of meiosis II

22 PropertyMitosisMeiosis DNA replication During interphase DivisionsOneTwo Synapsis and crossing over Do not occurForm tetrads in prophase I Daughter cells, genetic composition Two diploid, identical to parent cell Four haploid, different from parent cell and each other Role in animal body Produces cells for growth and tissue repair Produces gametes

23  Three events are unique to meiosis, and all three occur in meiosis l:  Synapsis and crossing over in prophase I: Homologous chromosomes physically connect and exchange genetic information.  At the metaphase plate, there are paired homologous chromosomes (tetrads), instead of individual replicated chromosomes.  At anaphase I, it is homologous chromosomes, instead of sister chromatids, that separate and are carried to opposite poles of the cell.

24  Mutations (changes in an organism’s DNA) are the original source of genetic diversity.  Mutations create different versions of genes.  Reshuffling of different versions of genes during sexual reproduction produces genetic variation.

25  The behavior of chromosomes during meiosis and fertilization is responsible for most of the variation that arises in each generation.  Three mechanisms contribute to genetic variation:  Independent assortment of chromosomes  Crossing over  Random fertilization

26  Homologous pairs of chromosomes orient randomly at metaphase I of meiosis.  In independent assortment, each pair of chromosomes sorts maternal and paternal homologues into daughter cells independently of the other pairs.  The number of combinations possible when chromosomes assort independently into gametes is 2 n, where n is the haploid number.  For humans (n = 23), there are more than 8 million (2 23 ) possible combinations of chromosomes.

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28 Crossing Over  Crossing over produces recombinant chromosomes, which combine genes inherited from each parent.  Crossing over begins very early in prophase I, as homologous chromosomes pair up gene by gene.  In crossing over, homologous portions of two nonsister chromatids trade places.  Crossing over contributes to genetic variation by combining DNA from two parents into a single chromosome. Prophase I of meiosis Tetrad Nonsister chromatids Chiasma, site of crossing over Recombinant chromosomes Metaphase I Metaphase II Daughter cells

29  Random fertilization adds to genetic variation because any sperm can fuse with any ovum (unfertilized egg).  The fusion of gametes produces a zygote with any of about 64 trillion diploid combinations.  Crossing over adds even more variation.  Each zygote has a unique genetic identity.

30  Natural selection results in accumulation of genetic variations favored by the environment.  Sexual reproduction contributes to the genetic variation in a population, which ultimately results from mutations.

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