1. UsefulChem: An Open Notebook Science Project Jean-Claude Bradley E-Learning Coordinator College of Arts and Sciences Associate Professor of Chemistry Drexel University Oct 23, 2007 ASIS&T Panel : Opening Science to All: Implications of Blogs and Wikis for Social and Scholarly Scientific Communication

2. Open and Closed Science Traditional Lab Notebook (unpublished) Traditional Journal Article Open Access Journal Article Open Notebook Science (full transparency) CLOSED OPEN

3. Where is Science headed? WE ARE HERE

4. How will this happen? Self-organizing redundant processes Self-organizing redundant processes Agents can Read/Write with zero cost (free hosted services – e.g. Google) Agents can Read/Write with zero cost (free hosted services – e.g. Google) Publication of all aspects of the scientific process: Open Notebook Science Publication of all aspects of the scientific process: Open Notebook Science

5. How can machines know what is important? Ask the humans

6. UsefulChem Blog

7. What chemists think is important in 2005

8. Malaria is a Logical Application of Open Science Very large problem: 300-500 million cases per year with one million deaths Not a lucrative market: IP control less important

9. Find-A-Drug

10. Diketopiperazine Library Evolves to: on pot Ugi reaction/cyclization First iteration: Solid Support Synthesis

11. The Molecules Blog

12. The Experiments Blog

13. Comments from peers

14. The UsefulChem Wiki

15. Telling the story of the failures

16. Experiments moved to wiki

17. Experiment History

18. Experiment Edits

19. Third Party Time-Stamp on Experiment Versions

20. Monitoring experimental progress

21. How are people finding our experiments?

22. Molecules found by InChI

23. Graphical Mining of Data with JSpecView usefulchem.wikispaces.com/Exp070 (48h 7 min)

24. usefulchem.blogspot.com The blog as an integrative tool

25. Processing Molecules on ChemSpider

26. Open Primary Research in Drug Design using Web2.0 tools (blogs, wikis, Second Life, mailing lists) Docking Synthesis Testing Rajarshi Guha Indiana U JC Bradley Drexel U Phil Rosenthal UCSF (malaria) Dan Zaharevitz NCI (tumors) Tsu-Soo Tan Nanyang Inst.

27. Mailing List Facilitates inter-group collaboration

28. UsefulChem and Open Science in Second Life scifooliveson.wikispaces.com

29. Question: Is it really a good thing to let anyone who thinks they have a scientific breakthrough have access to free, open, public, Googleable media? Question: Is it really a good thing to let anyone who thinks they have a scientific breakthrough have access to free, open, public, Googleable media? YES YES Question: What if I make a mistake in my data, never fix it, no one catches it, and then someone dies because a medical decision was based on my "findings"? Isn't this exactly why we have formal peer review in formal publications? Question: What if I make a mistake in my data, never fix it, no one catches it, and then someone dies because a medical decision was based on my "findings"? Isn't this exactly why we have formal peer review in formal publications? Peer review is not designed to catch errors from the analysis of raw data Peer review is not designed to catch errors from the analysis of raw data Open Notebook Science is more difficult where human subjects are involved Open Notebook Science is more difficult where human subjects are involved Question: Who is the audience for science blogs and wikis anyway? Scientists or laypeople? Question: Who is the audience for science blogs and wikis anyway? Scientists or laypeople? For UsefulChem, wiki is for chemists, blog for wider audience For UsefulChem, wiki is for chemists, blog for wider audience Question: Can you get published if you've already posted your results to your blog/wiki? Question: Can you get published if you've already posted your results to your blog/wiki? We’ll find out…. We’ll find out…. Question: Can scientists establish their credibilities/reputation by writing blogs and wikis? Question: Can scientists establish their credibilities/reputation by writing blogs and wikis? Certainly we’ve found collaborators this way Certainly we’ve found collaborators this way