1. Impact of clinical intervention bundle (CIB) on quality of care and mortality associated with Staphylococcus aureus bacteraemia (SAB) López-Cortés LE. ECCMID 2013 abs. O119 Multi-centre, before-after-study: N=462 pts with Staphylococcus aureus bacteraemia (SAB) (excluding palliative care or death within first 72h of SAB) from 11 Spanish tertiary hospitals CIB: Active consulting and follow-up of all SAB episodes by infectious disease specialist who provided written structured recommendations ≥3 days/week related to quality of care indicators Outcome parameters: Management (quality of care) and outcome (mortality) of SAB + 6 months Clinical intervention bundle (CIB) based on 5 evidence-based quality of care indicators 1 of 2

2. Quality of care Mortality Mortality during 6-month period: PRE: 27.6% vs INT: 23.6%; P=0.3 Multivariable logistic regression (adjusted for age, Pitt score, type of acquisition, development of severe sepsis/septic shock ) : CIB is independent predictor of lower mortality: OR=0.46; 95% CI: 0.25-0.87; P=0.02 Impact of clinical intervention bundle (CIB) on quality of care and mortality associated with Staphylococcus aureus bacteraemia (SAB) Application of a CIB for management of SAB may improve adherence to 3 quality of care indicators and decrease in-hospital mortality López-Cortés LE. ECCMID 2013 abs. O119 2 of 2

3. Outbreak of Elizabethkingia meningoseptica sepsis with meningitis in a well baby nursery Case report: N=3 newborns developing multi-resistant E. meningoseptica (Chryseobacterium meningosepticum) sepsis with meningitis in a well baby nursery (Taiwan; March-May 2012) Chen YJ. ECCMID 2013 abs. P957 1 of 2 Data from poster FU: follow-up; VP: ventriculoperitoneal

4. Outbreak of Elizabethkingia meningoseptica sepsis with meningitis in a well baby nursery An outbreak of E. meningoseptica sepsis and meningitis in a well baby nursery was possibly transmitted via contaminated facilities and was controlled after changing and sterilising them Chen YJ. ECCMID 2013 abs. P957 Intervention: Plastic storage boxes, cleaned with tap water without sterilisation → replaced by stainless steel boxes with regular desinfection 2x/week → no more E. meningoseptica infections since then 2 of 2 Data from poster

5. Risk of venous thromboembolism (VTE) after community-acquired bacteraemia (CAB) Population-based cohort study (Northern Denmark; 1992-2010): –Study group: N=4,237 adult pts with CAB, confirmed by blood cultures on admission to medical ward (exclusion criteria: no recent hospital admission, no previous CAB or VTE) –Control group: 10 non-hospitalised controls for each CAB patient, matched for age, sex and date of admission Dalager-Pedersen M. ECCMID 2013 abs. O287 1 of 2

6. Risk of venous thromboembolism (VTE) after community-acquired bacteraemia (CAB) CAB is associated with an increased risk of first-time VTE 3 months and 1 year after diagnosis. However, the absolute risk of hospital- diagnosed VTE after CAB is low Dalager-Pedersen M. ECCMID 2013 abs. O287 90-day risk of VTE after CAB according to organism: Highest for Staphylococcus aureus: 3.62% Adjusted relative risk (RR) for VTE after CAB: 2 of 2