1. University of Pittsburgh Mark J. Gartner Harvey S. Borovetz Workshop on BME Teaching of Innovation, Design & Entrepreneurship

2. Two semester senior-level biomedical integrated product design course First semester Computer aided engineering (SolidWorks) Finite element analysis (ANSYS) Computational fluid dynamics (Fluent) Statistical design of experiments (DesignExpert) Lectures focusing on fundamental components of product design Second semester Team design projects –3 to 4 member teams organized by post-graduation plans and common interest –Project topics formulated by instructor and team –Team “advisor” selected based on needs of team, expertise of advisor, and focus of project University of Pittsburgh BIOENG 1160/1161 Bioengineering Design I, II (MJG)

3. Two separate, one semester, upper level elective courses Bioeng 1050 Topics: Heart, Lung, Blood Vessel Term Project: –Design a Pediatric VAD –Improve the Design of VADs or ECMO Based on the Known Clinical Complications UoP (& FDA) staff with industrial experience serve as “advisers” & “consultants” Bioeng 1051 Topics: Kidney, Blood, Liver Term Project: –Design a Biohybrid Artificial Liver (starting point – existing BAL) University of Pittsburgh BIOENG 1050/1051 Artificial Organs I, II (HSB)

4. University of Pittsburgh Overall Pump Design (www.kinderheart.com)

5. Describe particularly novel and/or effective methods you use to teach innovation & entrepreneurship BIOENG 1160/1161 Initial survey of post-graduation plans and interests Choice of deliverable –Business plan -> entry into business plan competition –NIH-format grant (SBIR/STTR Phase I, R01) Market-based focus –Marketing, basic finance and accounting principles instruction –Incorporation of market-based deliverables into project Marketing plan and strategy Manufacturing plan Incorporation of organizational behavior principles –Personality determination –Dysfunctions of groups Cross-fertilization with MBA students at Katz School of Business at University of Pittsburgh University of Pittsburgh

6. How do you measure outcomes? BIOENG 1160/1161 Comparison of negotiated deliverables in first semester with results in second semester Is the deliverable patentable or publishable? Feedback from advisor/independent reviewer (e.g., business plan competition coaches) University of Pittsburgh

7. Describe a course project or exercise that exemplifies “best practices” BIOENG 1160/1161 Reverse-engineering/product dissection –Each design team dissects representative products Requirement to observe similar product in clinical use – generation of human-factors related observations Comparative medical/non-medical design requirements –How do the critical elements of design differ for a bone screw versus a simple fastener University of Pittsburgh