1. KIDNEY LECTURES 2015-6 DayTimeQuarter 5LecturerSubject Tue 10:00 a-11:00 a12/1/2015Lu, YuxinKidney I - Glomerular Disease Tue 11:00 a-12:00 p12/1/2015Lu, YuxinKidney II - Tub/Interst/Vasc Thu8:00 a-9:00 a12/3/2015Lee Kidney III - UT Obstruction/Cystic no lab

2. ROBBINS BASIC PATH 9 th EDITION READING ASSIGNMENTS Lecture 1: Glomerular Diseases – 517-533 Lecture 2: Tubulointerstitial and Vascular diseases – 533-542 – Review Lupus, pp. 125-131; and Amyloidosis, pp. 153- 158 Lecture 3: Cystic/Obstructive/Tumors/Transplant -542- 549 – Review Transplant Rejection, pp. 135-139

3. OLD LEARNING OBJECTIVES Describe the clinical and pathologic features of: Describe the clinical and pathologic features of: Lecture 1 Lecture 1 – Infection-related glomerulonephritis – Crescentic Glomerulonephritis – Membranous Nephropathy – Membranoproliferative Glomerulonephritis – IgA Nephropathy – Minimal Change Nephropathy – Focal Segmental Glomerulosclerosis – Chronic Glomerulonephritis

4. OLD LEARNING OBJECTIVES Lecture 2 – Lupus Erythematosis – Diabetes Mellitus – Amyloidosis – Pyelonephritis – Drug-Induced Acute Interstitial Nephritis – Hypertensive Nephropathy – Thrombotic Microangiopathy

5. OLD LEARNING OBJECTIVES Lecture 3 – Hydronephrosis – Urolithiasis – Congenital and Cystic Renal Diseases – Acute Tubular Necrosis – Rejection of Renal Allograft

6. APC Consensus Objectives, to consider (Next 6 slides):

7. Glomerular Disease Los (For Kidney 1) UTK5.1 Describe the proliferative and pro-inflammatory pathologies of conditions presenting with nephritic syndrome. UTK5.2 Describe the pathophysiology and morphologic features of nephrotic syndrome. UTK5.3 Compare and contrast the mechanisms of immune complex and antibody mediated glomerulonephritis. UTK5.4 Describe the pathogenesis of diabetic nephropathy and the associated clinicopathologic features. UTK5.5 Describe the pathogenesis of the nephropathies associated with dysproteinemia.

8. Tubulo-interstitial LO’s (For Kidney 2) UTK2.1 Describe the clinicopathological features and pathogenesis of tubulointerstitial diseases and discuss how their pathogenesis relates to treatment and outcomes. UTK2.2 Compare and contrast acute pyelonephritis, drug-induced interstitial nephritis, and lupus nephritis in terms of pathogenesis, clinical presentation, histopathological appearance, and treatment. UTK2.3 Compare and contrast ischemic and nephrotoxic forms of acute tubular injury, including typical clinical contexts, pathogenesis of renal failure, microscopic appearance, and expected outcome.

9. Renal Vascular LO’s (For Kidney 2) UTK3.1 Compare thrombotic and embolic causes of renal arterial occlusions in terms of underlying pathogenesis, gross and microscopic pathological anatomy and clinical presentation. UTK3.2 Discuss how the pathogenesis of hypertension leads to structural changes in the renal vasculature and how the characteristic pathological vascular lesions of the kidney seen in hypertension cause renal dysfunction. UTK3.3 Compare and contrast typical hemolytic uremic syndrome (HUS), atypical HUS, and thrombotic thrombocytopenic purpura (TTP) in terms of clinical presentation, renal histopathology, pathogenesis, and prognosis.

10. Cystic Disease LO (For Kidney 3) UTK4.1 Compare autosomal dominant and autosomal recessive polycystic kidney disease in terms of pathological anatomy, molecular pathogenesis, and clinical presentation.

11. Cystitis/Stones/Obstruction Los (For Kidney 3) UTB2.1 Recognize the typical clinical symptomatology of acute cystitis. UTB2.2 Identify the most common non-infectious causes of cystitis. UTB2.3 Describe situations in which cystitis may result in mass lesions of the urinary bladder. UTB3.1 Describe the pathogenesis of bladder diverticula, including congenital and acquired, and their potential role in infection, lithiasis and obstruction and occult carcinoma. UTB3.2 List the different chemical types of nephrolithiasis, and explain the pathophysiologic mechanisms related to development, and therapy/prevention of urinary stones. UTB3.3 Explain several causes of urinary obstruction.

12. (For Kidney 3) IM1.8 Discuss consequences of tissue transplantation, including mechanisms and pathophysiology of organ rejection, and the possible therapeutic interventions that can mitigate these effects.