1. APCOM’07-EPMESC XI, Kyoto, 3-6 December 2007 Lungs: Bronchial tubes Mass conservation: Momentum conservation: “Tube law”: Gray’s Anatomy

2. APCOM’07-EPMESC XI, Kyoto, 3-6 December 2007 Lungs: Alveolar Volume Volume-average blood flow: — ratio of the average lungs volume to the average alveolar pressure — air sluggishness — sluggishness of the tissues composing respiratory apparatus — hydraulic resistance of respiratory tract — hydraulic resistance of the respiratory tissues — extensibility of the respiratory tissues

3. APCOM’07-EPMESC XI, Kyoto, 3-6 December 2007 Lungs: Boundary conditions Junction with alveolar volume: Junction:Nasopharynx: Gray’s Anatomy

4. APCOM’07-EPMESC XI, Kyoto, 3-6 December 2007 Lungs: structure

5. APCOM’07-EPMESC XI, Kyoto, 3-6 December 2007 Drug injection

6. APCOM’07-EPMESC XI, Kyoto, 3-6 December 2007 Substance inspiration

7. APCOM’07-EPMESC XI, Kyoto, 3-6 December 2007 Substance inspiration (organs connected by 4 vessel trees) 0 sec 3 sec lung (small veins) pulmonary veins 7 sec20 sec6 sec arm (arteries) arm

8. APCOM’07-EPMESC XI, Kyoto, 3-6 December 2007 Drug injection (thigh) 2 sec arteriesveinstissue 15 sec arteriesveinstissue systemic arteries 0.3 sec