1. Lung Cancer Research Clinical Research Network South West Peninsula Julie Cunningham Research Delivery Manager Oncology / Haematology / Genetics 1

2. National Cancer Specialty Recruitment Data from Portfolio ODP – Cut off 06/12/15

3. South West Peninsula Cancer Specialty Recruitment Data from Portfolio ODP – Cut off 06/12/15

4. Lung Tumour Group National Perspective Data from Portfolio ODP – Cut off 06/12/15

5. Lung Tumour Group National Perspective Data from Portfolio ODP – Cut off 06/12/15 CRN 2014/20152015/2016 RecruitmentRank Adjusted Recruitment RankRecruitmentRank Adjusted Recruitment Rank East Midlands259959101449329 Eastern542314622294614 Greater Manchester343511741597546 Kent, Surrey and Sussex661315 43121014 North East and North Cumbria8612281232131013 North Thames36546882145398 North West Coast644117512992812 North West London10511531146112311 South London27888961578507 South West Peninsula4315191417158 Thames Valley and South Midlands56142413271412 Wessex3376124328831061 West Midlands55029754101723 West of England1921081713310555 Yorkshire and Humber334762917163110 Data adjusted to regional population, expressed as recruitment per 1M people

6. Lung Tumour Group SWP Recruitment Data from Portfolio ODP – Cut off 06/12/15

7. Lung Tumour Group - Study Type Data from Portfolio ODP – Cut off 06/12/15 33% 35% 65% 67%

8. Lung Tumour Group - Study Design Data from Portfolio ODP – Cut off 06/12/15 37% 63% 100%

9. AcronymStudy TypeUKCRNIDTrust Investigator Name End dateTarget Recruitment (EDGE) Recruitment (Portfolio) RTT Rating CANC - 3853 ARCTICCommercial17682RCHT Talbot, Dr Toby 28-Sep-1731019 CANC - 4122 PACIFICCommercial18180RCHT Talbot, Dr Toby 28-Oct-19200 Checkmate - 171Commercial18933PHNT Yiannakis, Dr Dennis 15-Apr-211500-5 Genetics of EGFR Mutation Study (GEM): a Translational Study of the EORTC Lung Group (EORTC 08114) Non- Commercial 16457RCHT Talbot, Dr Toby 01-Aug-171201214-36 Lung ART Non- Commercial 5686RD&EFord, Dr Vicky25-Oct-18200-39 Lung ART Non- Commercial 5686T&S Walther, Dr Julie 25-Oct-18400-37 LungCAST - Does smoking status after a diagnosis of lung cancer affect outcomes? Non- Commercial 9851T&S Pepperell, Dr Justin 01-Mar-17449381161 NCRN - 2974 VESTA: Veliparib, carboplatin & paclitaxel in NSCLC Commercial16393NDHCT Napier, Dr Mark 31-Mar-16211-20 STOMP Non- Commercial 10873PHNT Yiannakis, Dr Dennis 15-Nov-1413294 Lung Tumour Group – Open Studies from RAG Report Data from CRN SWP RAG Report from EDGE – November 2015

10. NICE Pathway for Lung Treatment

11. Non-Commercial Study Opportunities SPECIAL: Standard or PalliativE Care In Advanced Lung cancer Does early referral of patients with metastatic non-small cell lung cancer to UK specialist palliative care services make a difference in their quality of life or survival? (http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=18810)http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=18810 OPTIMUM Trial -Randomised controlled trial comparing outpatient management of malignant pleural effusion via an indwelling pleural catheter and talc pleurodesis versus standard inpatient management in improving health related quality of life. (http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=19615)http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=19615 GEM (EORTC 08114) - Genetics of EGFR Mutation Study (GEM): a Translational Study of the EORTC Lung Group (http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=16457)http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=16457 TAPPS - Evaluating the efficacy of thoracoscopy and talc poudrage versus pleurodesis using talc slurry: a randomised trial to determine the most effective method for the management of malignant pleural effusions in patients with a good performance status (http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=12537)http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=12537 TARGET Trial - Randomised controlled trial to compare the diagnostic yield of Positron Emission Tomography Computerised Tomography (PET­CT) targeted pleural biopsy versus CT­guided pleural biopsy in suspected pleural malignancy (http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=19364)http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=19364 The VIOLET study - VIdeo assisted thoracoscopic lobectomy versus conventional Open LobEcTomy for lung cancer, a multi-centre randomised controlled trial with an internal pilot (http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=18341)http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=18341 CEDAR - A Phase II, randomised, open-label study of Gemcitabine/Carboplatin first-line chemotherapy in combination with or without the antisense oligonucleotide Apatorsen (OGX427) in advanced squamous cell lung cancers (http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=16622)http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=16622 DIAPHRAGM - Diagnostic and Prognostic biomarkers in the Rational Assessment of Mesothelioma (http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=15376)http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=15376 MARS2 - A study to determine if it is feasible to recruit into a randomised trial comparing (extended) pleurectomy decortication versus no pleurectomy decortication in the multimodality management of patients with malignant pleural mesothelioma (http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=15909)http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=15909

12. SWP Lung cancer Strategy? Prevention Smoking cessation Early diagnosis – CANDID Smoking cessation at diagnosis Treatment QOL studies Palliative care 12