1. Patient with Presumptive TB HIV Status PositiveNegative % Empiric Tx of Patients with Active TB % Empiric Tx of TB-Symptomatic Patients without True TB Test 1 Smear Xpert CXR Culture LAM User Test 1,2,3 Test 2 None Smear Xpert CXR Culture LAM User Test 1,2,3 DST Test 1 None Xpert LPA Culture User Defined DST Test 2 None Xpert LPA Culture User Defined PositiveNegative Overall Schematic Rif Resistant Rif Susceptible DS TB = Initiate 1 st line treatment MDR TB = Initiate 2nd line treatment

2. New Patient with Presumptive TB HIV- PositiveNegative % Empiric Tx of Patients with Active TB % Empiric Tx of TB-Symptomatic Patients without True TB Test 1 Smear Xpert CXR Culture User Test 1,2,3 Test 2 None Smear Xpert CXR Culture User Test 1,2,3 DST Test 1 None Xpert LPA Culture User Defined DST Test 2 None Xpert LPA Culture User Defined PositiveNegative HIV+ PositiveNegative % Empiric Tx of Patients with Active TB % Empiric Tx of TB-Symptomatic Patients without True TB Test 1 Smear Xpert CXR Culture LAM User Test 1,2,3 Test 2 None Smear Xpert CXR Culture LAM User Test 1,2,3 DST Test 1 None Xpert LPA Culture User Defined DST Test 2 None Xpert LPA Culture User Defined PositiveNegative General Schematic

3. Schematic

4. New or Retreatment Patient with Presumptive TB HIV- PositiveNegative 10% Empiric Tx of Patients with Active TB 5% Empiric Tx of TB-Symptomatic Patients without True TB Test 1: Smear Test 2: GXP PositiveNegative Example from Quick Start Initiate 1 st or 2 nd line treatment based on GXP results HIV+ PositiveNegative 10% Empiric Tx of Patients with Active TB 5% Empiric Tx of TB-Symptomatic Patients without True TB Test 1: Smear Test 2: GXP DST Test (2): GXP PositiveNegative Rif Resistant Rif Susceptibl e MDR TB = Initiate 2 nd line treatment DS TB = Initiate 1 st line treatment