1. TASHKENT MEDICAL ACADEMY
Department of Bioorganic and Biological Chemistry
Bioorganic chemistry
I COURSE
SUBJECT: Multifunctional compounds Involved in the life process.
LECTURE№6
LECTURER : PROFESSOR A.D.DZHURAEV

2. PURPOSE OF LECTURES:
Generate knowledge of specific chemical properties and spatial structure of multifunctional compounds as a basis for understanding their metabolic transformations in the body.

3. Issues discussed include:
1. Structure and nomenclature of multifunctional compounds with the same function
2. The chemical properties of multifunctional compounds
3. derivatives of urea
4. Some representatives of polyfunctional compounds and their importance in medicine

4. HOCH2-CH2OH Ethylene glycol
Polyhydric alcohol
HOCH2-CH2OH
Ethylene glycol
glycerol
xylitol
sorbitol H O t
inozit
mioinozit
myoinositol

5. PROPERTIES POLYHYDRIC ALCOHOL
Interaction with salts and hydroxides of heavy metals

6. The dehydration reaction
dioxane
Objectified. terms
18-crown-6
к-18-crown-6

7. DEHYDRATION GLYCEROL
acrolein (tear gas)

8. EDUCATION ESTERS C H 2 O N B r bronopol 3-nitro "Nitron"
-glycerophosphate
-glycerophosphate C H 2 O N B r
bronopol

9. Polyhydric phenols
catechol
guaiacol
resorcinol
hydroquinone

10. Polyhydric phenol derivatives
sinestrol
diethylstilbestrol
cannabidiol
salicylic alcohol

11. Gossypol
gossypol

12. Diamine
ethylenediamine
putrescine
cadaverine

13. polycondensation reaction
geksametiletilen
diamine
adipic acid
nylon

14. 1,3 – Dicarbonyl compounds
glyoxal
diacetyl
acetylacetone

15. Keto-enol tautomerism
Dynamic equilibrium "keto" and "enol" forms in the 1,3-dicarbonyl compounds called phenomenon of tautomerism
ketone
enol

16. Quinones
1,4-benzoquinone

17. Derivatives of quinones
ubiquinone
phylloquinone (вит К1)

18. Naphthoquinone derivatives
figon
naphthalene
1,4-naphthoquinone
lavsan
juglone

19. Anthraquinone derivatives
anthracene

20. Dicarboxylic acids and their Properties
oxalic
acid
malonic
acid
amber
acid
glutaric
acid
glutaric
anhydride
succimide

21. Dibasic aromatic carboxylic acids:
phthalic anhydride
phthalic acid

22. Polycondensation reaction
dimethyl triphosphate
lavsan
Ethylene glycol

23. Unsaturated dicarboxylic acid
Fumaric
acid
Maleic
acid
maleic
anhydride

24. Derivatives of carbonic acid
Carbonic acid chloride
phosgene
carbamic acid
urea
diethyl carbonate
ethyl ester хлоругольной кислоты

25. ethyl
carbamate (urethane) -
has psychotropic effects
meprobamate, a tranquilizer

26. REACTION HEAT UREA: slow biuret isocyanuric acid fast negros
tautomeric forms
isocyanuric
acid
fast negros

27. Analytical reactions of urea:

28. Urea derivatives - Ureido
Ureido ACETIC ACID
Acetic acid ureides

29. Urea derivatives
BROMURAL (BROMIZOVAL)
hypnotics
IMINOMOCHEVINA