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31. Mapping the Auditory System in Rhesus Monkeys NIMH, July 2002 University of Iowa Neuroscience Program The University of Iowa Department of Psychology Behavioral and Cognitive Neuroscience

32. Auditory cortex Unfolded view of supratemporal plane and adjoining STG. Belt Parabelt Core Kaas and Hackett, PNAS 2000

33. Auditory Projection System Lower Brainstem Lower Brainstem IC MGB IC Early Auditory Areas MGB Early Auditory Areas

34. Auditory Projection System Lower Brainstem Lower Brainstem IC MGB IC Early Auditory Areas MGB Early Auditory Areas Corpus Callosum, Anterior & Posterior Commissures Tectal Commissures

35. Lower Brainstem Lower Brainstem MGB Early Auditory Areas MGB Early Auditory Areas Forebrain Comm. Tectal Comm. IC Intact side 'Deaf' side

37. Methods Speakers  2-DG injected intravenously  Monkey listens passively for 45 min  Wide variety of acoustic stimuli  Brain prepared for autoradiography  LCGU measured in ROIs throughout brain  ROIs compared for hemispheric asymmetries  Three surgically prepared monkeys

39. 2 DG in Intact (left) and Deafferented (right) Hemisphere Early auditory areas MGB IC

40. Columns of 2-DG activation in rSTG

41. Metabolic Mapping of Visual Cortex

42. Metabolic Mapping of Auditory Cortex

43. Overlap of Auditory and Visual Maps

44. Auditory and Visual Processing Streams

45. Parabelt projections to prefrontal cortex Romanski et al., Nature Neuroscience, 1999

47. Left HemisphereRight Hemisphere Superior Temporal Gyrus (STG) (n=7 monkeys) 1 2 3 4 5 % of Whole Brain Activity Monkey Vocalizations Complex Sounds and Vocalizations Complex Sounds No Vocalizations Ambient Background Sound 70 80 90 100 110 120 130 Human Vocalizations

48. High Low

49. High Low

50. Monkey Vocalizations p<0.001 * Complex Sounds and Vocalizations p<0.01 * FDG Activity in the Dorsal Temporal Pole 70 80 90 100 Ambient Background Noise % of Whole Brain Activity Left HemisphereRight Hemisphere

51. Monkey Vocalizations p<0.001 * Complex Sounds and Vocalizations p<0.01 * FDG Activity in the Dorsal Temporal Pole 70 80 90 100 Ambient Background Noise Left HemisphereRight Hemisphere Complex Sounds No Vocalizations % of Whole Brain Activity