1. To know more visit HeartFailure.com © 2015 Novartis Pharma AG, May 2015, GLCM/HTF/0028 HEART FAILURE PATIENT QUALITY OF LIFE STATISTICS

2. Heart failure patient quality of life statistics Heart failure can severely affect patients’ social capacity and emotional health 1 63 % OF HEART FAILURE PATIENTS REPORT SYMPTOMS THAT ARE CONSISTENT WITH DEPRESSION 2 Heart failure patients often suffer from anxiety or depression, feel a loss of self-control, and have difficulty performing daily activities. 3 1. Calvert MJ, Freemantle N, Cleland JGF. The impact of chronic heart failure on health-related quality of life data acquired in the baseline phase of the CARE-HF study. Eur J Heart Fail. 2005;7(2):243-251. 2. Moser DK, Dracup K, Evangelista LS, et al. Comparison of prevalence of symptoms of depression, anxiety and hostility in elderly heart failure, myocardial infarction and coronary artery bypass graft patients. Heart Lung. 2010;39(5):378-385. 3. Cowie MR, Anker SD, Cleland JGF. Improving Care for Patients With Acute Heart Failure: Before, During and After Hospitalization. Oxford PharmaGenesis; 2014. http://www.oxfordhealthpolicyforum.org/AHFreport. Accessed February 18, 2015.http://www.oxfordhealthpolicyforum.org/AHFreport Health care professionals can make a meaningful difference in the lives of heart failure patients

3. Heart failure can place a huge burden on patients, their families, and society as a whole 1 40 % OF PATIENTS STRUGGLE TO SOCIALISE OR ENGAGE IN DAILY ROUTINE ACTIVITIES WITH FRIENDS OR FAMILY The neurohormonal imbalance that causes the disease to progress is present in all heart failure patients, even in those who are considered asymptomatic (NYHA class I) or mildly symptomatic (NYHA class II). 1-3 60 % OF PATIENTS REPORTED DIFFICULTY WITH RECREATIONAL PASTIMES, SPORTS, OR HOBBIES 1. Ahmed A. A propensity matched study of New York Heart Association class and natural history end points in heart failure. Am J Cardiol. 2007;99(4):549-553. 2. Fauci AS, Braunwald E, Kasper DL, et al, eds. Harrison's Principles of Internal Medicine. 17th ed. New York: McGraw-Hill; 2008. 3. Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;128(16):e240-e327. > Heart failure patient quality of life statistics

4. The role of the multidisciplinary team of health care professionals is essential for the treatment of heart failure Heart failure can place a huge burden on patients, their families and the whole society 1 YOUR EXPERTISE CAN MAKE A MEANINGFUL DIFFERENCE IN THE LIVES OF PATIENTS Physician expertise and the ability to improve clinical outcomes can make a genuine difference in the lives of heart failure patients. 1,2 1. McMurray JJV, Adamopoulos S, Anker SD, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2012;33(14):1787-1847.2. Ponikowski P, Anker SD, AlHabib KF, et al. Heart failure: preventing disease and death worldwide. ESC Heart Failure. 2014;1(1):4-25.