1. Molecules of Life Part 1

2. Learning Objectives Explain that the mitochondria is the site of respiration. Describe how Watson & Crick built a model of DNA. Explain how genes and ribosomes are involved in making proteins.

3. Success Criteria You can label a diagram of an animal cell with its main components. You can create a leaflet on the discovery of DNA. You can answer some questions on protein synthesis.

4. Starter Use a whiteboard and marker to write down ideas you already have about: DNA Genes Chromosomes Inheritance You have 5 minutes until you feedback to the rest of the class.

5. What’s in a Cell? An animal cell contains the following parts: Copy this diagram into your book. Cell membrane – controls the movement of substances in and out of the cell. Nucleus – carries genetic information. Cytoplasm – where many chemical reactions happen. Chromosomes – genetic information is carried on these structures (DNA).

6. Mitochondria Along with everything present on the previous slide, there are also structures called mitochondria. Add a couple to your diagram. Remember back to year 10: You were taught that aerobic respiration released energy from glucose. The mitochondria are the site of this reaction. Mitochondria – the site of aerobic respiration.

7. Task 1.Match up each part of the cell with the job it does. Copy the completed table into your book. 2.Suggest a reason why sperm cells have many mitochondria. 3.Why might a cell need to make proteins? Part of CellJob NucleusMakes up most of the cell and is where dissolved chemicals can react. CytoplasmStructures in which respiration takes place. More active cells will have a larger amount. Cell membraneLarge structure which contains the chromosomes and therefore, the genetic material of the cell. MitochondriaThe barrier around the cell that controls the entry and exit of substances.

8. From DNA to Chromosomes It’s easy to forget DNA, genes and chromosomes mixed up. DNA is a molecule that is twisted into a double helix shape – like this. The molecule is very long and is split into genes which are codes for making proteins. A chromosome is simply a very long DNA molecule that has been folded into a shape like this: hair colour gene There’s a lot more DNA packed into the chromosomes than shown here!

9. Task 1.Complete Worksheet 1 and then stick it in your book. Answers: A. Top to bottom: membrane, nucleus, cytoplasm, chromosome, DNA, gene. B. Because liver cells need more energy from respiration.

10. Watson & Crick Watson & Crick contributed a lot to discovering the structure of DNA. However, there were others involved in the discovery too – namely Rosalind Franklin. She was instrumental, as it was her X-ray crystallography technique that indicated DNA had a double helix shape. Another scientist, Erwin Chargaff was responsible for discovering that DNA contained 4 bases (next lesson).

11. HIGHER

12. Higher The code stored within a DNA molecule is essential for making proteins. Proteins are made of chains of amino acids and the DNA controls the order of amino acids in a protein. Eg: This protein synthesis is carried out by ribosomes. Gene 1: Code = ATC GCT TGA CGT ACT Amino Acids: Gene 2: Code = GCT GCT ATC CGT TAC Amino Acids:

13. Task ALL: Create a leaflet on the discovery of DNA using information from this lesson and the student textbook. Include ideas about: the structure of DNA the names of the two scientists who first built a model of DNA the X-ray data they used to help them and the scientists that produced the X-rays the name of the scientist who found that there were pairs of bases the scientists that gained the Nobel prize for their work HIGHER: Your leaflet should also include reasons why some people may not have believed the scientists who made the discovery reasons why we are now more certain about the structure of DNA how DNA is linked to the role of ribosomes in the cell

14. HIGHER EXTENSION TASK

15. Higher Extension Task Read page 11 of the new student textbook and answer the following questions: 1.Which evidence was used to show DNA was a double helix? 2.Suggest why ribosomes can’t be seen using a light microscope. 3.Why was Rosalind Franklin’s work so important in the discovery of DNA? 4.Why is it important that scientists repeat the work of other scientists. 5.As DNA is made of two strands, can you think of a possible copying mechanism it may have?

16. Answers 1.The X-ray crystallography evidence obtained by Rosalind Franklin and Maurice Wilkins. 2.Light microscopes aren’t powerful enough. 3.It showed that DNA wasn’t a triple-stranded molecule, but a double-stranded molecule. 4.To validate the results of others. 5.The strands separate and form a template for new strands to form.

17. PLENARY

18. Answer the questions 1-10 in the student textbook.

19. Answers Q1 Nucleus Q2 Gene Q3 Watson and Crick Q4 Muscle cells need a lot of energy and mitochondria release energy during respiration Q5 Bases Q6 X-ray crystallography Q7 Erwin Chargaff Q8 Too small Q9 Confirmed DNA was a double helix not a triple helix Q10 To make the results more valid

20. Learning Objectives Explain that the mitochondria is the site of respiration. Describe how Watson & Crick built a model of DNA. Explain how genes and ribosomes are involved in making proteins.

21. Success Criteria