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目录 Chapter 4 Vitamins
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目录 James Lind
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目录 Christian Eijkman (Ducth) found Vit.B 1 ( Nobel Prize for Medicine and Physiology,1929) Albert Szent-Gyorgyi (Hungarian) found Vit.C ( Nobel Prize for Medicine and Physiology,1937) Dam (Dane) found Vit.K ( Nobel Prize for Medicine and Physiology,1943)
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目录 Concept : vitamins are chemically unrelated organic compounds that cannot be synthesized in adequate quantities by humans and, therefore, must be supplied by the diet. Vitamin
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目录 Characteristics : 1. neither the component of the organization nor the energy material ; 2. the requirement is limited. 3. It can not be synthesized by humans (or a little), and must be supplied by diet 。
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目录 Fat-soluble Vitamin : Vitamin A 、 D 、 E 、 K Water-soluble Vitamin : B-Complex vitamin, Vitamin C B-Complex vitamin : B l, B 2, PP, B 6, pantothenic acid, biotin, Folic acid, B 12, etc. Classification:
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目录 Section 1 Fat-soluble Vitamin
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目录 Common characteristics : ( 1 ) Lipid soluble ; ( 2 ) They are released, absorbed and transported with the fat of diet ( 3 ) They are transported with lipoproteins or some special binding proteins in blood ; ( 4 ) They are stored in the liver and adipose tissue. Types : Vit A, Vit D, Vit E, Vit K
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目录 1. The chemical natures and properties (1) Natural forms (2) Active forms : Ⅰ. Vitamin A Retinol, retinal, retinoic acid A 1 ——Retinol , mainly exists in livers of mammals and seawater fish; A 2 ——3-dehydrogenation retinol , mainly exists in livers of freshwater fish.
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目录 (3) Sources : CH 2 OH 15 / VitA ( VitA 原) β- Carotene × 2 animal giblets, plants——Vitamin A former ( e.g. β- Carotene )
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目录 2. Function and deficiency diseases (1) It is a component of the visual pigments of rod and cone cells Rod cells : Rhodopsin = opsin + 11-cis retinal Deficiency diseases: Night blindness
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目录 Deficiency diseases: Darier disease Xerosis cutis (2) It is essential for normal differentiation of epithelial tissues and mucus secretion. Xerophthalmia
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目录 (4) It is an efficient antioxidant (3) It influences the cell differentiation
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目录 (1) Types : VitD 2 : in plants VitD 3 : in animal tissue 1. The chemical natures and properties Ⅱ. Vitamin D UV VitD 3 7-Dehydrocholesterol UV VitD 2 Ergosterol
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目录 Vit D 3 25-OH-VitD 3 1, 25- ( OH ) 2 -VitD 3 Liver Kidney (2) Active form of VitD 3 : 1, 25- (OH) 2 -VitD 3
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目录 (3) (3) Sources : cod liver oil, animal liver, eggs…
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目录 (2) It influences the cell differentiation (1) Maintain adequate plasma levels of calcium 2. Function and deficiency diseases
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目录 children——rickets adults——osteomalacia (3) Deficiency diseases :
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目录 High doses can cause loss of appetite , nausea, hypercalcemia, etc. (4) Toxicity of vitamin D
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目录 (1) Types : tocopherol , tocotrienols 1. The chemical natures and properties ( 、 、 and ) (2) Sources : Ⅲ. Vitamin E Vegetable oils are rich sources of vitamin E.
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目录 deficiency diseases: hemolytic anemia 2. Function and deficiency diseases (1) Antioxidation
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目录 (3) Promote the metabolism of protoheme (2) Prevent and cure the threatened abortion and habitual abortion deficiency diseases: sterility Clinical practice deficiency diseases: Neonatal anemia
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目录 K 、 K (2) Synthetic : K 3 、 K 4 (1) Natural forms : K 1 ---- phylloquinone ( in plants ) K 2 ---- menaquinone ( in intestinal bacterial ) Ⅳ. Vitamin K 1. The chemical natures and properties
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目录 It is required in the synthesis of prothrombin and blood clotting factors. (3) Sources : Plants ; intestinal bacterial 2. Function and deficiency diseases
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目录 deficiency diseases: bleeding easily
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目录 Section 2 Water-soluble Vitamin
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目录 Water-soluble and readily excreted in the urine. They must be absorbed from the food frequently and can not be stored. They are precursors of coenzymes for the enzymes. Types : B-Complex vitamin, Vitamin C Common characteristics
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目录 (1) Vit. B 1 ------- thiamine (2) Active form: thiamine pyrophosphate ( TPP) 硫胺素 (thiamine) TPP Ⅰ. Vitamin B 1 1. The chemical natures and properties
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目录 In many foods. (3) Sources :
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目录 (1) TPP is the coenzyme for the pyruvate dehydrogenase. deficiency diseases: beriberi 2. Function and deficiency diseases
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目录 (2) TPP is the coenzyme for transketolase in pentose phosphate pathway. deficiency diseases: indigestion (3) Inhibit the activity of cholinesterase.
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目录 Ⅱ. Vitamin B 2 Flavin mononucleotide (FMN ) Flavin adenine dinucleotide (FAD ) ( 2 ) Active forms: ( 1 ) Vit. B 2 ------ riboflavin 1. The chemical natures and properties
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目录 Vit B 2 FMNAMP FAD Ⅰ ⅡⅢ
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目录 Milk and milk products, liver, eggs, meat, etc (3) Sources: 2. Function and deficiency diseases FMN and FAD are the prosthetic group for oxidation-reduction enzyme, which can reversibly accept two hydrogen atoms.
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目录 deficiency diseases: Cheilitis angular stomatitis
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目录 Ⅲ. Vitamin PP (1) Vit. PP including : niacin nicotinamide (2) Active forms: nicotinamide adenine dinucleotide (NAD + ) nicotinamide adenine dinucleotide phosphate ( NADP + ) 1. The chemical natures and properties
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目录 NAD + : R 为 H NADP + : R 为 Nicotinamide AM P
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目录 (3) Sources : In many foods. They are the coenzymes for anaerobic dehydrogenase 2. Function and deficiency diseases
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目录 3D : dermatitis 、 diarrhea 、 dementia 。 deficiency diseases: pellagra
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目录 Ⅳ. Pantothenic acid (1)pantothenic acid (2) Active forms: coenzyme (CoA) acyl carrier protein (ACP) (3) Sources : Widely distributed (plants, animals, intestinal bacterial…) 1. The chemical natures and properties
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目录 泛酸 4- 磷酸泛酰 巯基乙胺 CoA 的结构式 AMP
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目录 2. Function and deficiency diseases They are the coenzymes for acyltransferase.
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目录 Ⅴ. Biotin α-biotin——in yolk β-biotin——in liver (1) Types : Biotin deficiency does not occur naturally because it is widely distributed in food. It also can supplied by intestinal bacteria in humans. (2) Sources : 1. The chemical natures and properties
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目录 (1) It is a prosthetic group for carboxylase. (2) It takes part in signal transduction and gene expression 2. Function and deficiency diseases
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目录 Ⅵ. Vitamin B 6 1. The chemical natures and properties (1) Types : pyridoxine, pyridoxal, pyridoxamine (2) Active forms: pyridoxal phosphate pyridoxamine phosphate
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目录 2. Function and deficiency diseases (1) Pyridoxal phosphate is the coenzyme for aminopherase and decarboxylase. (2) Pyridoxal phosphate is the coenzyme for ALA synthase.
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目录 no deficiency in general. (3) Pyridoxal phosphate is the coenzyme for enzyme of hyperhomocysteinemia catabolism. deficiency diseases:
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目录 F Dihydrofolate reductase NADPH+H + NADP + Dihydrofolate (FH 2 ) NADPH+H + NADP + FH 4 Ⅶ. Folic acid 1. The chemical natures and properties Dihydrofolate reductase (1) Active form: Tetrahydrofolate (FH 4 ) (2) Sources : It is widely distributed in green plants In liver
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目录 Megaloblastic marrow Normal marrow 2. Function and deficiency diseases FH 4 plays a key role in one-carbon metabolism, is essential for the biosynthesis of nucleic acid. deficiency diseases: megaloblastic anemia
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目录 Ⅷ. Vitamin B 12 Methylcobalamin 5 - deoxyadenosyl-cobalamin (1) Vit. B 12 ------- cobalamine Liver, kidney, lean meat, fish, eggs, etc. 1. The chemical natures and properties (2) Active forms: (3) Sources :
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目录 H CONH 2 CH 3 N H CH 2 CONH 2 H N CH 2 CONH 2 CH 3 R : -CH 3 R : 5`- 脱氧腺苷 H H H H CH 2 OH O OH N N CH 3 O P O O O CH CH 3 CH 2 NH CO CH 2 Co + C CH 3 R H C N H CONH 2 CH 2 N CH 3 CH CH 3 CH 2 CONH 2 CH 2 A B C D
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目录 hyperhomocysteinemia 2. Function and deficiency diseases It plays key roles in methyl transfer and one- carbon metabolism. deficiency diseases: megaloblastic anemia
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目录 Ⅸ. Vitamin C (1) Vit. C------ ascorbic acid (2) Strong reducing ability, unstable. 1. The chemical natures and properties (3) Sources : It is widely distributed in fresh vegetables and fruits.
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目录 (1) Participate in REDOX reaction; (2) Participate in the transformation of cholesterol; (3) Protect sulphur enzyme can not be oxidated; (4) Combined with the heavy metal ions and ruled out of the body. 2. Function and deficiency diseases Scurvey deficiency diseases:
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