1. Integumentary System

2. The integumentary system includes the skin and all of its appendages (hair, nails, and skin glands). It consists of two layers: epidermis and dermis. Epidermis – outermost layer consists of stratified squamous epithelial tissue; no blood vessels. Dermis – composed of connective tissue; contains collagen fibers, elastin fibers, and reticular fibers; blood vessels, sweat glands, sebaceous glands, nerve endings, and hair follicles. Hypodermis – areolar and adipose tissue; binds skin to underlying tissue.

3. Cutaneous Membrane Epidermis Dermis Hypodermis

4. Layers of Epidermis View animation on “The generation of skin layers” Stratum basale Stratum corneum

5. Layers of Epidermis Innermost layer is the stratum basale (basal layer or stratum germinativum), a layer of columnar stem cells that continually undergo mitosis to produce new skin cells. New skin cells push older cells upward and they stop dividing, producing keratin. Cells reach the outermost layer, the stratum corneum, and only keratin is left. These keratinocytes replace dead cells that flake away with daily wear. Stratum corneum consists of up to 30 layers of dead, flat, keratin-coated cells making the skin’s surface durable and resistant to abrasions. It also forms an effective barrier, preventing water from entering the body from the outside whereas still allowing for evaporation.

6. Skin Color Melanocytes produce melanin. Melanin protects the nucleus from ultraviolet (UV) exposure. The amount and type of melanin determines skin color. Two types of melanin: pheomelanin – a reddish color eumelanin – a brown-black color Various disorders can produce abnormal changes in skin color, such as cyanosis, jaundice, bronzing, albinism, erythema, pallor, and hematoma.

7. Functions of the Skin Protection Barrier Vitamin D production Sensory perception Thermoregulation

8. Question New skin cells produce which tough, fibrous protein? A. Collagen B. Elastin C. Melanin D. Keratin

9. Hair Shaft Hair follicle Hair bulb or root Papilla Arrector pili

10. Hair The hair shaft extends above the skin’s surface. Each hair lies within a sheath of epidermis called a hair follicle. Buried in the dermis is the hair bulb or root where growth occurs. At the base of the hair is a cluster of connective tissue and blood vessels called the papilla that nourishes each hair. Attached to each hair follicle is a small bundle of smooth muscle called the arrector pili muscle.

11. Nails Nail body Cuticle Lunula Nail bedNail root

12. Nails Nails consist of densely packed, heavily keratinized epithelial cells. Nail body – visible part of the nail; cuticle – a fold of skin surrounding nail body; lunula – a crescent-shaped white area at the base. Nail bed – layer of epithelium under the nail; normally appears pink because of the rich blood supply in the area. Nail root – proximal end of the nail. Various disorders can cause changes in nails, including clubbing, cyanosis, flattened or concave nail beds, dark lines beneath nail, white nails, yellowish nails, pale nail beds.

13. Sweat Glands Eccrine gland Apocrine gland Sebaceous gland

14. Sweat Glands There are two types of sweat glands: eccrine glands and apocrine glands. Eccrine glands contain a duct that leads from the secretory portion to the skin’s surface; produce sweat, which contains potassium, ammonia, lactic acid, uric acid, and other wastes. Apocrine glands contain a duct that leads to a hair follicle; these are scent glands that respond to stress and sexual stimulation. Sweat does not have a strong odor unless it accumulates on the skin. Sebaceous glands open into a hair follicle; secrete an oily substance called sebum, which helps keep the skin and hair from drying out and becoming brittle

15. Question Which glands secrete sweat onto the skin’s surface? A. Apocrine glands B. Eccrine glands C. Sebaceous glands D. Ceruminous glands

16. First-Degree Burn Involves only the epidermis Causes redness, slight swelling, and pain Often results from sunlight (sunburn) First- and second-degree burns are partial-thickness burns.

17. Second-Degree Burn Involves the epidermis and part of the dermis Results in blisters, severe pain, and swelling May result in scarring May appear red, white, or tan

18. Third-Degree Burn Extends into the subcutaneous layer May not be painful initially May appear white or black and leathery Often requires skin grafts Complications include infection, fluid loss, and lack of thermoregulation Eschar secretes toxins and promotes bacterial growth; it can also restrict circulation

19. Question A 36-year-old woman comes to the emergency department after being exposed to steam from a broken water heater. She describes extreme pain. The skin on her face is red with white patches, swollen, and beginning to blister. What is the most likely diagnosis? A. First-degree burn B. Second-degree burn C. Third-degree burn D. A severe scalding injury