1. DeletionInversion Duplication Translocation HAPPY MONDAY 1 2 34 -You have 10 minutes for the quiz. -Read the article on your table about Sickle-Cell Anemia -DRAW each CHROMOSOMAL MUTATION and label according to the back of PAGE 64

2. Collect Today M.K.M.S. Quiz Page 61 – Mitosis vs Meiosis Corrections Page 66 – Stem Cell Webquest Assigned Page 65 – Mutations Coloring (Tomorrow) Page 67 – Mutation Lab (Tomorrow) Unit 4 Exam (Wednesday) Vocab Cell Cycle MAKE-UP Quiz (Thursday) IBB Quiz (Some time this week) Late Page 63 – Build a Karyotype (-50%)

3. Essential Question How do mutations affect the composition of proteins? Standard B.6E – Identify and illustrate changes in DNA and evaluate the significance of these changes PG 67

4. Genetic tests are now available for hundreds of disorders making it possible to determine whether prospective parents risk passing such alleles to their children. DNA testing can pinpoint the exact genetic basis of a disorder making it possible to develop more effective treatment for individuals affected by genetic disease.

5. Beneficial mutations may produce proteins with new or altered activities that can be useful to organisms in different or changing environments.

6. Lab - Mutation Practice Back Page -Read the ARTICLE about SICKLE-CELL ANEMIA from the perspective of the role assigned to you. -Roles Person #1 – Doctor Person #2 – Expecting Parents Person #3 – Traveling to Africa Person #4 – Reporter -Each person create 3 SENTENCES for YOUR response to the question, “Is genetic testing harmful or beneficial in regards to sickle-cell anemia?”. -Discuss with your 4 person-group your responses. -Create a 47 word Quickwrite summarizing your GROUP response on Person #1’s paper – turn in before you leave today. Front Page -Use the cubes to create the EXACT mRNA strand provided on the handout. -You will have an extra cube, you will use it later. -Use Page 47 and Page 64 to help answer questions 1-7. (Ask 3, then me!) **Homework: Complete the handout and you will need to finish Page 65 – Mutations (coloring).** A U U C G G PG 67