1. Exposure Reconstruction for the Epidemiologic Study June 2010

2. Exposure Reconstruction Defines common exposure subgroups Quantifies exposures for subgroups If there is an excess, then seeks association between exposures and effects If there is no excess effect, exposure reconstruction however refined will not associate an agent with an effect or explain an effect UIC 2010

3. Exposure Reconstruction Performed on: –Parts manufactured –Processes used to manufacture parts –Individual agents Part and process analyzed to ensure any unsuspected agent that may be associated with a possible effect would not be missed UIC 2010

4. Individually Examined Contaminants Cohort –Evaluate mortality and work exposures Chromium Cobalt Degreasing solvents Ionizing radiation Lead-cadmium Magnetic fields Metalworking fluids (oil & water based) Nickel Case-control –Evaluate CNS incidence and more detailed work exposures All of the cohort exposures as well as: PCB’s Metalworking fluid combustion products specific to North Haven UIC 2010

5. Exposure Reconstruction Protocol Leaves no stone unturned –Considers all suspected agents –Considers all employment categories as defined by job dictionary –Considers all significant subgroups as defined by parts –Considers all different aspects of work as defined by manufacturing processes involved UIC 2010

6. Acknowledgement The researchers would like to thank the Communications Facilitation Workgroup, P&W employees, union, and management personnel, and the CT Department of Public Health for their continued support and contributions to the study.