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Test 1Test 2Test 3Test 4Test 5Test 6 Sensitivity2.510.576.1608887.2 Specificity100 917098.296.3 PPV100 90.574.598.397.3 NPV475376.562.587.586.5 Performance.

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Presentation on theme: "Test 1Test 2Test 3Test 4Test 5Test 6 Sensitivity2.510.576.1608887.2 Specificity100 917098.296.3 PPV100 90.574.598.397.3 NPV475376.562.587.586.5 Performance."— Presentation transcript:

1 Test 1Test 2Test 3Test 4Test 5Test 6 Sensitivity2.510.576.1608887.2 Specificity100 917098.296.3 PPV100 90.574.598.397.3 NPV475376.562.587.586.5 Performance Characteristics of Six Commercial IgM Tests Relative to the CDC IgM Capture EIA* * Assay comparison study was an ARRA-funded project done in conjunction with the APHL Santa Clara County Public Health Department and Iowa State Hygienic Laboratory performed the testing.

2 Measles Specimens Referred to CDC for Confirmatory or Reference Testing – 2006 to 2011

3 National Center for Immunization and Respiratory Diseases Division of Viral Diseases Measles was laboratory-confirmed in 48 (87%) cases 20 (42%) by detection of measles-specific IgM antibodies only 24 (50%) by detection of measles-specific IgM antibodies and measles virus RNA 4 (8%) by detection of measles virus RNA only Laboratory Confirmed Measles Cases in USA: 2012

4 National Center for Immunization and Respiratory Diseases Division of Viral Diseases Laboratory Confirmed Measles Cases in the USA, 2013 with Laboratory Results Shared with CDC IgM only32 (45%) IgM and PCR26 (37%) PCR only12 (17%) Total70

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