1. The financial support of the European Commission is gratefully acknowledged. Material in this presentation reflects only the author’s views and the Commission is not liable for any use that may be made of the information contained herein. Siegfried Benkner Institute of Scientific Computing University of Vienna, Austria for the Aneurist Consortium www.aneurist.org October 5, 2007

2. @neurISTCopyright © 2007 2 EU Project @neurIST (2006-2009) IST-2004-027703 Development of a generic IT infrastructure for the management and processing of heterogeneous data associated with the diagnosis and treatment of cerebral aneurysms and subarachnoid haemorrhage. Integrated Application Suites @neuRisk - personalised risk assessment @neuEndo – virtual endovascular treatment planning & stent design @neuLink - linking genetics to disease @neuFuse - modeling, simulation & visualization of multimodal data @neurIST service-oriented Grid infrastructure on-demand simulation and analysis services (semantic) data-integration services handling multi-scale, multi-modal information at distributed sites. http://www.aneurist.org

3. @neurISTCopyright © 2007 3 Integrative Application Suites Gen data Personal data Imaging data @neuLink @neuRisk @neuFuse Genetic risk databases @neuEndo Epidemiology knowledge Patient Pharma treatment Modelling, simulation and analysis services Modelling, simulation and analysis services

4. @neurISTCopyright © 2007 4 @neurIST Grid Infrastructure Storage Resources BioISFiles Databases Compute Resources AnalysisSimulation Modeling Basic @neurIST Grid Layer (GEMSS2 / InnerGrid) OGSA-DAI GDMS Data Transfer Job Execution @neuInfo Services@neuCompute Services @neurIST Client API @neuFuse Multimodal data processing&fusion @neuEndo Virtual endovascular treatment planning @neuLink Linking genetics to disease @neuRisk Integrative rupture risk assesment @neurIST Controller Application Layer Resource Layer Middleware Layer Grid Middleware: GEMSS2, InnerGrid; Standard Web Services (WS-I) Data Integration: OGSA-DAI – WS-DAI; DQP; SQL Semantics: OWL, SPARQL

5. @neurISTCopyright © 2007 5 Data Integration Approach Semantic Data Mediation Federation of Services CRIM, Ontology Security, Pseudonymization, … Hospital information systems Sheffield, Geneva, Rotterdam,… EHR, PACS, … Public databases Genetic: EBI,NCBI Literature: Medline, etc. Product design databases COTS stents, coils, etc. Applications Users PACS PUBMED PACS Data Service OGSA/DAI GDMS Data Service OGSA/DAI GDMS Data Service OGSA/DAI GDMS PDD EHR

6. @neurISTCopyright © 2007 6 Clinical Reference Information Model (CRIM) Defines all information to be captured for a patient clinical information (imaging, diagnostic and treatment data, …) administrative information research results produced (indicators) Biomedical data infostructure Two different architectures (see next slide) Research ContextTreatment context Federated Biomedical Info Structure Data Capturing Imaging data Patient record Application Suites Processing & Analysis Distributed queries Knowledge discovery Denormalization Re-identification Normalization De-identification Information aquisition & structuring Information access, analysis & enrichment

7. @neurISTCopyright © 2007 7 Geneva (OTF) Sheffield (ANO) anoDB XML/DICOM files Files WS with SQL query XML WS with SQL query XML Hospital Intranet Data forms EHR PACS IDDB PACS EHR Acquisition tool IDDB Private @neuInfo Service Public @neuInfo Service FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL FIREWAL FIREWALL FIREWALL FIREWALL FIREWALL FIREWALL Push mechanism University network/DMZ Public @neuInfo Service Internet Data Acquisition Data Storage Data Access Hospital Intranet Hospital DMZ Logging Filtering Logging Filtering DICOM HL7 SQL DVD FTP HTTP/XML

8. @neurISTCopyright © 2007 8 @neurIST Ontology Global conceptual schema of the disease Conceptual space Clinical Medicine Molecular Biology Epidemiology Simulation Disease Risk factor Incorporating “approved” existing ontologies FMA - Foundational Model of Anatomy GO - Gene Ontology DOLCE as Upper Ontology Concepts are mapped to Unified Medical Language System (UMLS) OWL-DL Lead partner: University of Freiburg ClassesRelationship Types DefinitionsUMLS Map 21398510961183

9. @neurISTCopyright © 2007 9 GDMS DAS Semantic Data Integration Schema Virtual Schema Mapping Data Access Services Data Mediation Services Ontology OGSA-DAI annotation

10. @neurISTCopyright © 2007 10 Pseudonymisation Service End-to-end security Attribute-based access control (ABAC) Certificate and Registration Authorities; Federated VO model Security Token Service Logging, Filtering Services Auditing Provenance built on top of Web services security standards @neurIST Security Architecture

11. @neurISTCopyright © 2007 11 Contact Project co-ordinator: Universitat Pompeu Fabra Contact person: Dr.Alejandro Frangi Tel: +34 93 542 14 51 Fax: +34 93 542 25 17 Email: alejandro.frangi@upf.edualejandro.frangi@upf.edu WWW: http://www.aneurist.org