1. Essentials of Human Anatomy & Physiology Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slides 13.1 – 13.30 Seventh Edition Elaine N. Marieb Chapter 13 The Respiratory System Lecture Slides in PowerPoint by Jerry L. Cook

2. Organs of the Respiratory system Slide 13.1 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Nose  Pharynx  Larynx  Trachea  Bronchi  Lungs – alveoli Figure 13.1

3. Function of the Respiratory System Slide 13.2 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Gas exchange – diffusion of O2/CO2 at alveoli of lungs and blood  Passageways (nares) purify, warm, and humidify the incoming air

4. The Nose Slide 13.3a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Nares – “nostrils”; Air enters  The interior of the nose consists of a nasal cavity divided by a nasal septum

5. Slide 13.3b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 13.2 Upper Respiratory Tract

6. Anatomy of the Nasal Cavity Slide 13.4a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Olfactory receptors are located in the mucosa at top of inner nares  The rest of the cavity is lined with respiratory mucosa  Moistens air  Traps bacteria/foreign particles

7. Anatomy of the Nasal Cavity Slide 13.4b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Lateral walls have projections called conchae  Increases surface area  Increases air turbulence within the nasal cavity

8. Paranasal Sinuses Slide 13.5a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Cavities within bones surrounding the nasal cavity  Frontal, Sphenoid, Ethmoid, & Maxillary bones  Function of the sinuses  Lighten the skull  Act as resonance chambers for speech  Produce mucus that drains into the nasal cavity

9. Pharynx (Throat) Slide 13.6 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Connect nasal cavity to larynx  Auditory tubes enter the nasopharynx  Tonsils of the pharynx  Pharyngeal tonsil (adenoids)  Palatine tonsils  Lingual tonsils at the base of the tongue Structures of the Pharynx

10. Pharynx (Throat)

11. Larynx (Voice Box) Slide 13.8 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Routes air and food into proper channels  Plays a role in speech  Made of eight rigid hyaline cartilages and a spoon-shaped flap of elastic cartilage (epiglottis)

12. Structures of the Larynx Slide 13.9a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Thyroid cartilage  Largest hyaline cartilage  Protrudes anteriorly (Adam’s apple)  Epiglottis  Superior opening of the larynx  Routes food to the larynx and air toward the trachea

13. Structures of the Larynx Slide 13.9b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Vocal cords (vocal folds)  Vibrate with expelled air to create sound (speech)  Glottis – opening between vocal cords

14. Trachea (Windpipe) Slide 13.10 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Connects larynx with bronchi  Lined with ciliated mucosa  Beat continuously, Expel mucus w/dust & other debris away from lungs  Walls are reinforced with C-shaped hyaline cartilage - keep trachea from collapsing due to pressure changes.

15. Primary Bronchi Slide 13.11 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Trachea divides into L & R.  Right bronchus is wider, shorter, and straighter than left  Bronchi subdivide into smaller and smaller branches….bronchioles….then finally alveolar sacs.

16. Lungs Slide 13.12a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Occupy most of the thoracic cavity  Apex near clavicle  Base rests on diaphragm  Each lung is divided into lobes  Left lung – two lobes  Right lung – three lobes

17. Lungs Slide 13.12b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 13.4b

18. Coverings of the Lungs Slide 13.13 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Pulmonary (visceral) pleura covers the lung surface  Parietal pleura lines the walls of the thoracic cavity  Pleural fluid fills the area between layers of pleura to allow gliding

19. Respiratory Tree Divisions Slide 13.14 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Primary bronchi  Secondary bronchi  Tertiary bronchi  Bronchioli  Terminal bronchioli

20. Respiratory Zone Slide 13.16 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Structures  Respiratory bronchioli  Alveolar duct  Alveoli  Site of gas exchange

21. Gas Exchange Slide 13.19 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Gas crosses the respiratory membrane by diffusion  Oxygen enters the blood  Carbon dioxide enters the alveoli  Macrophages add protection  Surfactant coats gas-exposed alveolar surfaces

22. Events of Respiration Slide 13.20a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Pulmonary ventilation – moving air in and out of the lungs  External respiration – gas exchange between pulmonary blood and alveoli

23. Pressure Differences in the Thoracic Cavity Slide 13.24 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Normal pressure within the pleural space is always negative (intrapleural pressure)  Differences in lung and pleural space pressures keep lungs from collapsing

24. Nonrespiratory Air Movements Slide 13.25 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Can be caused by reflexes or voluntary actions  Examples  Cough and sneeze – clears lungs of debris  Laughing  Crying  Yawn  Hiccup

25. Gas Transport in the Blood Slide 13.33a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Oxygen transport in the blood  Inside red blood cells attached to hemoglobin (oxyhemoglobin [HbO 2 ])  A small amount is carried dissolved in the plasma

26. Gas Transport in the Blood Slide 13.33b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Carbon dioxide transport in the blood  Most is transported in the plasma as bicarbonate ion (HCO 3 – )  A small amount is carried inside red blood cells on hemoglobin, but at different binding sites than those of oxygen

27. Internal Respiration Slide 13.34a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Exchange of gases between blood and body cells  An opposite reaction to what occurs in the lungs  Carbon dioxide diffuses out of tissue to blood  Oxygen diffuses from blood into tissue

28. Internal Respiration Slide 13.34b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 13.11

29. Respiratory Disorders: Chronic Obstructive Pulmonary Disease (COPD) Slide 13.40a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Exemplified by chronic bronchitis and emphysema  Major causes of death and disability in the United States

30. Respiratory Disorders: Chronic Obstructive Pulmonary Disease (COPD) Slide 13.40b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Features of these diseases  Patients almost always have a history of smoking  Labored breathing (dyspnea) becomes progressively more severe  Coughing and frequent pulmonary infections are common

31. Respiratory Disorders: Chronic Obstructive Pulmonary Disease (COPD) Slide 13.40c Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Features of these diseases (continued)  Most victimes retain carbon dioxide, are hypoxic and have respiratory acidosis  Those infected will ultimately develop respiratory failure

32. Emphysema Slide 13.41 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Alveoli enlarge as adjacent chambers break through  Chronic inflammation promotes lung fibrosis  Airways collapse during expiration  Patients use a large amount of energy to exhale  Overinflation of the lungs leads to a permanently expanded barrel chest  Cyanosis appears late in the disease

33. Chronic Bronchitis Slide 13.42 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Mucosa of the lower respiratory passages becomes severely inflamed  Mucus production increases  Pooled mucus impairs ventilation and gas exchange  Risk of lung infection increases  Pneumonia is common  Hypoxia and cyanosis occur early

34. Chronic Obstructive Pulmonary Disease (COPD) Slide 13.43 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 13.13

35. Lung Cancer Slide 13.44 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Accounts for 1/3 of all cancer deaths in the United States  Increased incidence associated with smoking  Three common types  Squamous cell carcinoma  Adenocarcinoma  Small cell carcinoma

36. Asthma Slide 13.46 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Chronic inflamed hypersensitive bronchiole passages  Response to irritants with dyspnea, coughing, and wheezing

37. Tuberculosis

38. Collapsed lung (Pneumothorax)

39. Aging Effects Slide 13.48 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Elasticity of lungs decreases  Vital capacity decreases  Blood oxygen levels decrease  Stimulating effects of carbon dioxide decreases  More risks of respiratory tract infection

40. Respiratory Rate Changes Throughout Life Slide 13.49 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Newborns – 40 to 80 respirations per minute  Infants – 30 respirations per minute  Age 5 – 25 respirations per minute  Adults – 12 to 18 respirations per minute  Rate often increases somewhat with old age