1. Welcome to Immunology Course

2. IMMUNOLOGY Prof. dr Vera Pravica Prof. dr Dušan Popadić Doc. dr Miloš Marković Assist. dr Emina Savić imunologija@med.bg.ac.rs Tel. 3643-236 Facebook: Antitelija Limfocitic

3. Immunitas (lat.) protection, immunity organs, tissues, cells and molecules involved in defence of the organism process that results in immunity resistant to (infectious) disease Basic terminology Immunity Immunization Immune Immune system state of resistance to (infectious) disease coordinated activity of the immune system components Immune response Immunis,-e (lat.)protected, immune Protection of senators against prosecution, tax payment and other civil duties in Antic Rome

4. Basic function(s) of the immune system Defense against infectious agents Recognition and elimination of cancer cells

5. viruses bacteria helmints fungi protozoa

6. - mechanisms of recognition of “danger” signal - mechanisms of activation and regulation of defense - effector mechanisms of destruction and elimination of pathogens and neutralization of their harmful products - mechanisms leading to immune response injurious to own tissue - possibilities for manipulation of the immune response IMMUNOLOGY investigates

7. IMMUNITY INNATE (Natural) (Native) ADAPTIVE (Aquired)

8. Mechanisms of innate and adaptive immunity - amplified upon re-exposure to the same pathogen - fully functional after certain period (days, weeks) - appears in vertebrates INNATE IMMUNITYADAPTIVE IMMUNITY - filogenetically older - immediate action - does not change throughout a lifetime - early line of defence Mutually stimulating - reacts against both infectious and non-infectious substances - later but more effective - reacts predominantly against infectious agents

9. Principle mechanisms of innate and adaptive immunity

10. Properties of adaptive immunity - diversity and specificity - memory - clonal expansion - autotolerance - specialization - stimulation of mechanisms of innate immunity

11. Types of adaptive immunity - based on effector mechanisms cellular or cell-mediated (T-lymphocytes) humoral (B-lymphocytes)

12. Types of adaptive immunity

13. - based on effector mechanisms cellular or cell-mediated (T-lymphocytes) humoral (B-lymphocytes) - based on manner of activation active passive - based on mode of induction natural artificial

14. IMMUNIZATION PASSIVE ACTIVE NATURAL (infection) ARTIFICIAL (vaccination) NATURAL (Mother-to-fetus antibody transfer) ARTIFICIAL (serum therapy)

15. Simplified presentation of immune network