1. CDRP Steering Committee UPMC McKeesport January 20th, 2006

2. Clinical Trials RTOG 232 A phase III study comparing combined external beam radiation and transperineal interstitial permanent brachytherapy with brachytherapy alone for selected patients with intermediate risk prostatic carcinoma Anticipated accrual: 4 males: 2 black/2 white Status:

3. Clinical Trials RTOG 315 A randomized, double blind, placebo-controlled phase III study to determine the efficacy of sandostatin lar  depot (ostreotide chemoradiation-induced diarrhea in patients with anal or rectal cancer Anticipated accrual: 3 (1 white female; 1 white male; 1 black male) Status: Open Mercy; pending IRB at 4 other sites

4. Clinical Trials RTOG 126 A phase III randomized study of high dose 3D- CRT/IMRT versus standard dose 3D-CRT/IRMT in patients treated for localized prostate cancer Anticipated accrual: 1 white male Status: Open at McKeesport, Murtha, Jameson; not open Mercy; pending IRB Somerset

5. Clinical Trials RTOG 235/ACRIN 6668 Positron emission tomography pre- and post- treatment assessment for locally advanced non- small cell lung carcinoma Anticipated accrual: 7 (1 black female/2 black males; 2 white female/2 white male) Status: Pending PET machine accreditation McKeesport/Murtha; pending IRB Somerset; not open at Mercy; pending IRB Jameson

6. Clinical Trials RTOG 214 A Phase III comparison of prophylactic cranial irradiation versus observation in patients with locally advanced non-small cell lung cancer Accruals to date: 2 white male Anticipated accrual: 5 (2 black male; 1 white female/2 white male) Status: Open Mercy, Murtha, Jameson, McKeesport; Somerset pending IRB

7. Publications ASTRO – Poster (10/05) Analysis of “best practice” treatment patterns for a radiation oncology community outreach group (ROCOG) engaged in cancer disparities research (Proctor, et al) RSNA – Poster (11/05) Use of formative evaluation to measure progress within start-up programs (Morgenlander, et al)

8. Publications American Telemedicine Assoc. – Poster (5/06) A multi-institutional regional/mobility model: Deployment for TELESYNERGY  (Schenken, et al) Academy Health – submitted Evaluation of the tailored patient navigator programs for the underserved populations with cancer (Lin, et al)

9. Publications “An evolving Plan for Evaluation of the Web-based Communication and TELESYNERGY® Components of the UPMC McKeesport/ROCOG Minority Outreach Project” –by Edmund M. Ricci, Ph.D.(Professor and Director, Institute for Evaluation Science in Community Health, University of Pittsburgh), and Larry Schenken, Ph.D. in preparation “A Community Hospital-based, Collaborative Research Program to Reduce Radiation Oncology Disparities: A Developmental Case Study” –(Part 1 of a 3 part series) –by Morgenlander, Heron, Schenken, Proctor, Govern, Kalnicki, Herberman, Baum, Melani, Feinstein (proposed authorline– manuscript under internal review)

10. TELESYNERGY® Assurance of CME credit provided by Barbara Barnes, M.D., Vice President for Contracts, Grants, IP and CME programs for the University of Pittsburgh Medical Centers for all TELESYNERGY® based professional programs, either within ROCOG partners, or with our Mentors. To be directed by Dr. Heron and Coordinated by Dr. Schenken. Antonio Ambrad, M.D. appointed clinical coordinator and “ombudsman” for TELESYNERGY® utilization by oncology staff at UPMC McKeesport Enhanced linkage with Radiation Oncology resident training (Journal Club) at St. Louis. Concept initiated by Barb Klewien, and involving T. Michael White M.D., (Director of Medical Education at McKeesport), Larry Schenken, Ph.D., Stasia Miaskiewicz, M.D. (Internal Medicine residency training Coordinator-McKeesport)

11. TELESYNERGY® (cont) Continue to promote special programs facilitating interactions among our oncology staff and with Mentors; e.g.Respiratory Gating Issues in Radiation Oncology and Joint Case/Pathology Reviews comparing live time histopathology, jpeg stored images, and web-based ultra-high resolution auto- scanned imaging systems

12. Patient Navigator Program In operation since January 2005 in 2 of 5 institutions As of November 30, 2005, 100 patients consented to the program –59 at Mercy Hospital-urban hospital –41 at Jameson Hospital-rural hospital Top 3 primary barriers that Navigators deal with are: –Transportation (21%) –Insurance issues (12%) –Prescription coverage (10%)

13. Patient Navigator Program Implementing program in 2 more institutions by end of January 2006 –Somerset Oncology Center-rural –UPMC McKeesport-urban Physician education currently being completed in both institutions Navigators in place and being trained: –Didactic education program –Mentoring by other Navigators Navigator program implemented in 5 th institution in early spring, delay due to merger/funding