1. Leading Worldwide in Mixing Technology Advanced Process Solutions EKATO SYSTEMS GmbH – Public 1 UNIMIX - Vacuum processing units Scale-up Basics Rainer Liebig Project Manager Sales EKATO SYSTEMS GmbH

2. EKATO SYSTEMS GmbH – Public 2 Advanced Process Solutions Agenda  Vacuum Processing Plant UNIMIX – Features  Design Aspects  Parameters for Scale-up  Tip speed of PARAVISC  Mixing time of PARAVISC  Tip speed of Homogeniser  BTO – Batch Turn Over  Summary

3. EKATO SYSTEMS GmbH – Public 3 Advanced Process Solutions Vacuum Processing Plant EKATO UNIMIX Features:  Vacuum processing  Heating/cooling  Agitation with PARAVISC  High Sheer Homogenizer S-Jet  Raw material charging into homogenizer  Internal/external homogenisation

4. EKATO SYSTEMS GmbH – Public 4 Advanced Process Solutions Innovation for your process Professional scale-up calculation of Newtonian and non-Newtonian fluids.

5. EKATO SYSTEMS GmbH – Public 5 Advanced Process Solutions Scale-up calculation EKATO SYSTEMS is unique with the possibility to calculate the scale-up parameters to maximize the quality and quantity for our customer! Important Design Aspects  Tip speed of Homogenizer – 27 m/s  Tip speed of PARAVISC agitator – 2.5 m/s  Vessel design: ratio H / Ø = 1 : 1

6. EKATO SYSTEMS GmbH – Public 6 Advanced Process Solutions Scale up calculation - Parameters  Tip speed of PARAVISC agitator  Mixing time PARAVISC  Tip speed of Homogenizer  BTO’s (Batch Turn Over’s) at homogeniser  Product transfer in case of pre- phase vessels Tip speed Rotor (homogenisator) Tip speed PARAVISC

7. EKATO SYSTEMS GmbH – Public 7 Advanced Process Solutions Scale up calculation – Tip Speed PARAVISC C = π * n/s * d d SRT25 = 0,284 m d SRC1000 = 0,976 m n SRT25 = 120 rpm n SRC1000 = ? rpm C SRT25 = 3,14* 120/60s * 0,284 = 1,78 m/sec C SRC1000 = 3,14 * X /60s * 0,401 = 1,78 m/sec A B X =2* 0,284 / 0,976 = 0,581 * 60 = 34,8 rpm 3,14 * 120/60s * 0,284 = 3,14 * X/60s * 0,976 = 34,8 rpm

8. EKATO SYSTEMS GmbH – Public 8 Advanced Process Solutions Scale up calculation – Mixing Time PARAVISC t SRC1000 = (n SRT25 * t SRT25 ) / n SRC1000 t SRT25 = 2 min t SRC1000 = ? min n SRT25 = 120 rpm n SRC1000 = 34,8 rpm tip speed = 1,78 m/s t SRT1000 = (120 SRT25 * 2 SRT25 ) / 34,8 SRC1000 = 6:53 min

9. EKATO SYSTEMS GmbH – Public 9 Advanced Process Solutions Scale up calculation – Tip Speed Homogeniser C = π * n/s * d d SRT25 = 0,060 m d SRC1000 = 0,166 m n SRT25 = 6000 rpm n SRC1000 = ? rpm C SRT25 = 3,14 * 6000/60s * 0,060 = 18,8 m/sec C SRC1000 = 3,14 * x /60s * 0,166 = 18,8 m/sec A B 3,14 * 6000/60s* 0,060 = 3,14 * X/60s * 0,166 = 2164 rpm

10. EKATO SYSTEMS GmbH – Public 10 Advanced Process Solutions Scale up calculation – BTO (Batch Turn Over) at Homogeniser 25 L 1000 L S-jet 100 S-jet 1000 = 100 L/min H 2 O = 1000 L/min H 2 O 100 / 25 * 2:00 = 8 BTO‘s * = all with same tip speed of 18,8 m/sec t SRT25 = 2:00 min = 8 BTO’s t SRC1000 = ? min = 8 BTO’s 1000/1000 * 8 BTO‘s = 8:00

11. EKATO SYSTEMS GmbH – Public 11 Advanced Process Solutions Summary REMEMBER In order to succeed in the scale-up calculation, the following information need to be established:  Tip speed of PARAVISC agitator  Mixing time PARAVISC  Tip speed of Homogenizer  BTO’s (Batch Turn Over’s) at homogeniser

12. Thank you for your attention! Advanced Process Solutions EKATO SYSTEMS GmbH – Public 12