1. Veterans Aging Cohort Study (VACS)
Required:
Optional based on other project funding:

2. Now have support through August 2016 for a total of 20 years of follow up in Virtual Cohort and 16 years for VACS 8

3. VACS Cohort and Substudies
Virtual Cohort
pos 47,805 neg 99,061
VC/Queri
pos neg 70000
VACS 9
pos neg 3962
Exhale
pos neg 170
DNA
pos neg 900
CVD
pos neg117
Biomarkers
pos neg 800
Virtual Cohort(VC) comprised of national data. Elements include demographics, diagnostic and procedure codes, labs, pharmacy, vital signs…
VACS9 is the 9 site consented patient study with richer data. Includes surveys, adjudicated outcomes for cancer, mi, liver disease, site downloaded data
VC limited to patients in 2003 or later. Includes adjudicated MI from IHD Queri
Includes Ddimer, IL6, sCD14
3 VACS sites only. Includes GXT, CT and echo data

4. Virtual Cohort (VC) SUBJECTS: 47,805 HIV infected; 99,061 uninfected
All individuals with HIV diagnoses
Age, race/ethnicity, region 2:1 matched controls
Last updated: September 2014
Next update: Currently in progress
SITES: All VA sites
BASELINE: 1998 (15 years of follow up)
HIV infected veterans at initiation of HIV care
Controls selected and followed in same calendar year

5. VACS 9 BASELINE: 2002 (11 years)
CURRENT DATA SOURCES (all VC sources plus)
All VA Electronic medical records including text fields
Sentinel event records (MI) requested outside VA
DNA and tissue bank (subset of 2,300 patients)
Self completed surveys (health behaviors, quality of life, symptoms, outside utilization, etc.) every months
SUBJECTS: 3,790 HIV infected; 3,962 uninfected
Group matched: age, race/ethnicity, and site
Last updated October 16, 2013
SITES: Atlanta1, Bronx1, Houston1, Los Angeles1, New York1, Baltimore2, Washington DC2, Pittsburgh3, Dallas4, Nashville5
** present, present, present, present, present
BASELINE: 2002 (11 years)

6. National VACS/COMpAAAS Project Team 2014

7. COMpAAAS Steering Committee
Amy C. Justice, MD, PhD Consortium PI
Angela Consorte, Director Administrative Core
David Fiellin, MD, Director
Alcohol and Behavioral Intervention Core
Janet Tate, ScD, MPH, Director
Biostatistics Core
Cynthia Brandt, MD, MPH, Director Joseph Erdos, MD, PhD, Co-Director
Medical Informatics Core
Cores (supported by other grants): Directors
Cancer Disease: L Park, PhD, MPH & K Sigel, MD Cardiovascular Disease: M Freiberg, MD, MSc Liver Disease: V LoRe, MD & J Tate, ScD, MPH Pulmonary Disease: K Crothers, MD Translational Research: C Rinaldo, MD & M Freiberg, MD, MSc
Site PIs:
Atlanta: V Marconi, MD Baltimore: M Sajadi, MD Bronx: S Brown, MD Brooklyn/Manhattan: M Simberkoff, MD Dallas: R Bedimo, MD Houston: M Rodriguez-Barradas, MD Los Angeles: M Goetz, MD Nashville: T Hulgan, MD Pittsburgh: A Butt, MD Washington, D.C: C Gibert, MD
Workgroups: Directors
ART: N Gandhi, MD & J Tate, ScD, MPH Endocrine and Bone Disease: J Womack, APRN, PhD Health Services Research: E Wang, MD & K McGinnis, MS Kidney Disease: F P Wilson, MD Opioids: J Edelman, MD Physical Function and Disability: KA Oursler, MD Polypharmacy: A Justice, MD, PhD & J Edelman, MD Risk Index: A Justice, MD, PhD & J Tate, ScD, MPH Statins: R Bedimo, MD & J Tate, ScD, MPH Uniform Services: V Marconi, MD
Scott Braithwaite, MD, MSc, Director
Operations Research Core
Steering Committee
Kendall Bryant, PhD, Director Nancy Day, PhD David Leaf, MD Stephen Maisto, PhD Patrick O’Connor, MD, PhD David Rimland, MD Charles Rinaldo, MD Jeffrey Samet, MD, PhD
COMpAAAS

8. Acknowledgements Consortium PI : AC Justice*
Scientific Collaborator (NIAAA): K Bryant
Affiliated PIs: S Braithwaite, K Crothers*, R Dubrow, DA Fiellin*, M Freiberg*, V LoRe*, K Kraemer
Participating VA Medical Centers: Atlanta (V Marconi*), Baltimore (M Sajadi, R Titanji), Bronx (S Brown, Y Ponomarenko), Dallas (R Bedimo*), Houston (M Rodriguez-Barradas, N Masozera), Los Angeles (M Goetz, D Leaf), Manhattan-Brooklyn (M Simberkoff, D Blumenthal, H Leaf, J Leung), Pittsburgh (A Butt, K Kraemer, E Hoffman), and Washington DC (C Gibert, R Peck)
Core and Workgroup Chairs: B Agan, W Becker, C Brandt, J Edelman, N Gandhi, B Gulanski, K McGinnis, KA Oursler, L Park, C Rinaldo, K Sigel, J Tate, E Wang, F P Wilson, J Womack
Staff: H Bathulapalli, T Bohan, J Ciarleglio, A Consorte, L Erickson, S Felter, C Frank, K Gordon, J Huston, F Kidwai-Khan, G Koerbel, F Levin, S Shahrir, M Skanderson
Major Collaborators: VA Public Health Strategic Healthcare Group, VA Pharmacy Benefits Management, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Yale Center for Interdisciplinary Research on AIDS (CIRA), Center for Health Equity Research and Promotion (CHERP), ART-CC, NA-ACCORD, HIV-Causal
Cross Cohort Collaborators: Richard Moore (NA-ACCORD), Jonathan Sterne (ART-CC), Brian Agan (DoD), Miguel Hernan (HIV-Causal)
Major Funding by: National Institutes of Health: AHRQ (R01-HS018372), NIAAA (U24-AA020794, U01-AA020790, U01-AA020795, U01-AA020799, U24-AA022001, U24 AA022007, R01-AA023733, R01AA022886, U10 AA completed), NHLBI (R01-HL125032, RO1-HL126555, R01-HL completed, R01-HL completed) , NIAID (U01-A ), NIDA (R01DA035616, R03DA031592), NCI (R01 CA173754) and the Veterans Health Administration Office of Research and Development (VA REA , VA IRR Merit Award) and Office of Academic Affiliations (Medical Informatics Fellowship)
*Indicates individual is also the Chair of a Core or Workgroup

9. Acknowledgements Continued
Other Notable Funding: Career Development Awards: Veterans Health Administration: VISN 1 CDA (V1CDA ), HSR&D CDA-2 (08-276); National Institutes of Health: NINR (1K01R013437), NCRR/NCATS (5UL1RR024139), NIDA (1K12DA A1, 8UL1TR000142, 1R03DA031592)
COMpAAAS/Veterans Aging Cohort Study, a CHAART Cooperative Agreement, supported by the National Institutes of Health: National Institute on Alcohol Abuse and Alcoholism (U24-AA020794, U01-AA020790, U01-AA020795, U01-AA020799; U10 AA completed) and in kind by the US Department of Veterans Affairs.  In addition to grant support from NIAAA, we gratefully acknowledge the scientific contributions of Dr. Kendall Bryant, our scientific collaborator.
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