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Cell Membranes.

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Presentation on theme: "Cell Membranes."— Presentation transcript:

1 Cell Membranes

2 Cell Membrane Views

3 Phospholipid Molecule

4 Hydrophilic and Hydrophobic Molecules interacting differently with water

5 Wedge-shaped lipids form micelles
Cylinder-shaped lipids form bilayers

6 Spontaneous sealing of phospholipid bilayer

7 Liposomes

8 Phospholipid mobility

9 Cis-double bonds affect packing

10 Cholesterol glycolipids

11 Function of Cholesterol

12 Phospholipid types

13 Microdomains on plasma membrane
Lipid rafts Choresterol sphingolipids

14 Asymmetrical distribution of phospholipids and glycolipids

15 Phospholipids in cell signaling

16 Phospholipase Cleavage sites

17 Glycolipids

18 Membrane Proteins

19 Membrane Proteins

20 Fatty acid chain or prenyl group modifications

21 Hydropathy Plots

22

23 B-barrel membrane proteins

24 Membrane proteins are glycosylated

25 A detergent micelle

26 Solubilize membrane proteins with detergent

27 Detergents

28 Mild detergent for the solubilizing, purification, and reconstitution of membrane protein functions

29 SEM image of red blood cells

30 The preparation of red blood cell membranes

31 15 major membrane proteins in red blood cells

32 Membrane proteins are diffusable

33

34

35 Proteins restrictions

36 Protein distributions in a guinea pig sperm cell

37 4 ways of protein restrictions

38 Carbohydrate layer (Glycocalyx) on the cell surface

39 Diagram of glycocalyx

40 Summary Phospholipids, cholesterol, glycolipids for membrane
Asymmetric, inner and outer monolayer subcompartments and lipid functions in cell signaling membrane proteins and their anchoring models diffusion, distribution glycocalyx, proteoglycan

41 Membrane Transport of Small Molecules and the Electrical Properties of Membranes

42 Permeability of plasma membrane

43

44 Carrier Protein and Channel Protein

45 Transportation Models

46 Electrochemical Gradient

47 Ionophores

48 Conformational change of a carrier protein

49 Kinetics of simple and carrier-mediated diffusions

50 3 ways of driving active transportation

51 3 types of carrier-mediated transport

52 Coupled transportation of glucose and Na+

53 Transcellular transport

54 Na+-K+ Pump, ATPase

55 Cycles of Na+-K+ Pump

56

57 Functions of Na+-K+ Pump

58 ABC transporter 2 ATP-binding cassette domains

59 A typical Ion Channel

60 The gating of Ion Channels

61 The Structure of bacterial K+ channel

62

63 Gating Model of K+ channel

64 Summary Membrane transportation, carrier protein, channel protein
Active transportation, passive transportation ATPases, Na+-K+ Pump Gating mechanisms of Ion Channels, K+ channel selectivity


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