1. for Business for Life Inorganic Nanomaterials for Antimicrobial Protection Dr. Selvaraj Subbiah Materials Innovations for Infection Prevention 9 November 2009 Institute of Materials, Minerals and Mining, London

2. for Business for Life Intrinsiq Materials Ltd Leading Nanotechnology Company with a broad set of international customers and partners. Powerful Platform Technologies Novel tool for development and manufacture of novel nanomaterials Controlled release of high value actives Novel antimicrobial and antiviral materials Considered by HSE/HSL as leaders in safe inorganic nanomaterial production, handling, packing and shipping. Substantial IP portfolio of 34 patent families

3. for Business for Life IML’s Patented Development Tool & Production Process Feedstock Vaporised Cooled & Modified Nano product Nano Product IML is one of the few companies that has both a powerful development tool and scalable production process

4. for Business for Life Intrinsiq Materials – Made to Order MetalsOxides Carbidesand Nitrides Carbides and Nitrides Mixed Materials Aluminium, Copper Silver, Nickel Cobalt, Titanium Stainless Steel Tungsten, Silicon Tantalum Molybdenum Zinc Oxide, Copper Oxide Cerium Oxide, Tin Oxide Cuprous Oxide, Titanium Dioxide Nickel Oxide, Zirconium Oxide Tungsten Carbide Aluminium Nitride Aluminium Oxy Nitride Silicon Nitride Boron Nitride Blends Alloys Doped Structured Stoichiometry

5. for Business for Life TEM images of nano dispersion (in house technique, water based dispersion ) Extremely small particle distribution – easy to disperse

6. for Business for Life Positive Control (citric acid) IML Materials Actives Screening vs Controls Negative Control Antiviral Actives vs Influenza Virus – H5N1 (bird flu)

7. for Business for Life Antibacterial efficacy – E.coli PQN 842; effective for both organism ( 6-6.5 log reduction in 15 minutes)

8. for Business for Life Antibacterial efficacy – Staph.aureus

9. for Business for Life Application Flexibility Coated paper Filter media coated with active material Melt blown nonwoven Spun bond polyester HEPA glass fiber Nano coated Uncoated Nano-latex glove

10. for Business for Life Nanoparticles incorporated glove (different magnification) After washing with water 5K50KNP- Glove 80K Washing did not leach out antimicrobial active nanoparticles

11. for Business for Life Face mask with antimicrobial actives A BC A. Blank polypropylene material - uncoated B. Coated with Antimicrobial active-A C. Coated with Antimicrobial active-B Nanoparticle leaching: After incorporation, filter media was washed with water few times and SEM image was taken to confirm the presence of nanoparticles on the fiber

12. for Business for Life SEM image of nanoparticles incorporated facemask materials – after washing 4K 25K 50K

13. for Business for Life Nylon with nano particle- uniform fibers Nanoparticle incorporated nylon fibers made via Nanospider Potential for large scale production Further optimization needed

14. for Business for Life Intrinsiq Materials’ Solution Broad Spectrum Biocide antibacterial / antiviral / antifungal Performance Inorganic material and not organic material Durable Processing Flexibility Technology to incorporate nanoparticles into fibers / coatings etc Safety Components are well known and generally considered as safe

15. for Business for Life Summary Technology developed (for materials) and commercialised by globally recognised leaders in their fields Novel, multi-functional particles produced using plasma processing Demonstrated broad spectrum of activity Active against Gram +, Gram -, yeast, and pathogenic viruses Proven efficacy when coated on multiple substrates Strong IP position – ample “white space”

16. for Business for Life Thank you Business Development Enquiries: Dr. Ian Clark - Sales & Marketing Director (ianclark@intrinsiqmaterials.com)ianclark@intrinsiqmaterials.com