1. FROM IMAGES TO ANSWERS Portfolio de Productos de Media Cybernetics Olympus Latin America Q2 2006

2. New Releases for 2006 Image Pro Express 6 Scope Pro Express 6 Scope Pro 6 3D Constructor InVivo Analyzer 3D Constructor InVitro Analyzer 3D Constructor IQbase 2 Autoquant X Confocal Widefield AutoVisualize Image Pro Plus 6 Image Pro Analyzer 6 Scope Pro Express 6 3D Surface Analyzer Studio 2

3. New Releases Image Pro Express 6

4. New in Image Pro Express 6 Processing Tools: Edge filters Perform forward and inverse Fast Fourier Transforms (FFTs) to eliminate artifacts Create composite images from multiple gray scale images with the Color Composite Tool Measurement Features: Auto Threshold Metrology tools to measure best-fit line, arc and circle Calculate max, min and average thickness between lines Caliper tool to measure and detect edges Analysis Tools: Surface plot to display image intensity values in a 3D plot

5. Image Pro Express MC o ScopePro Express Scope-Pro Image-Pro Express Microscope Control Module Version 6.0 Combining tools to control and program your automated microscope or stage, Image-Pro Express Microscope Control includes: Microscope Control Module Scope-ProScope-Pro Express EjeZ y Shutter o +

6. Image Pro Express 3DS Offering tools for deconvolution and interactive control and analysis of 3D volume stacks, Image-Pro Express 3D Suite includes: Version 6.0 Image Deconvolution Module 3D Rendering & Measurement Module Image-Pro Express SharpStack3D Constructor

7. Entry Level Applications ItemBundle de Image Pro Express 6Price OMC-1956Image Pro Express (IPE6)$1500 OMC-1956 Image Pro Express & ScopePro Express$2500 OMC-1963Image Pro Express & Scope Pro (IPE6-MC)$3250 OMC-1956 Image Pro Express SP-Exp 3D Surface Inspector$3500 OMC-1956Image Pro Express 3DS$5200 OMC-19 OMC-1956 Image Pro 3D ScopePro Express$6200

8. New Releases Image-Pro Plus 6

9. Top New Features in Image-Pro 6 Live Image Scaling for Low-Light Applications Live Data Collection and Charting XP x64 Support to Open Larger Image Sets Open GL 3D Viewer Direct Import of QED Files (File, Open) User-Defined Equation Editor in Data Collector Dynamically Linked Graphic Display in Data Collector Embedded I/O Control for Serial and Parallel Devices ICC Color Profiles

10. Image-Pro 6 Enhancements Image-Pro Plus 6 Feature Enhancements: Updated Capture Dialog Scalable Calibration Markers User-Specific Menus “Dark Mode” for Low Light Laboratory Environments Automatic Measurement of >100,000 Objects (Memory-Dependent) Intelligent Macro Editor (not Intelli-Sense, but something much like it ;) ) 3D Convolution Filters More Extensive File Support (FV1000, JPEG2000, etc.) Export to Excel or Origin Generate Movies from Surface Plot 6-Month License for IQbase 2 (Optional Permanent License at Extra Cost)

11. New Open GL 3D Viewer

12. New Data Collector Tools

13. Updated Capture Dialog

14. New Dark Mode

15. Top New Features in Scope-Pro 6 3-Point Predictive Focus for Wavy Samples Support for Simultaneous Stepper and Piezo Drives (X, Y, and Z) Calibrated Continuous Zoom Support for Olympus SZ-X Objective Paracentricity (X,Y) Offsets Analog/TTL Support for Shutters, Filter Wheels, AOTF’s and Monochromators Nyquist Calculator for Z-Axis Acquisition Support for the Olympus ZDC

16. Image-Pro Family Modules Automate Motorized Microscopes and Other Acquisition Devices A/D & D/A Acquisition & Support for External Devices SharpStack Plus includes: 3D Blind, 2D Blind deconvolution algorithms plus No Neighbor, Nearest Neighbor and Inverse Filter algorithms Turbo Scan High Speed Tiling Back as a Plug-In by Popular Request

17. QImaging* (Excellent) Olympus DP50 / DP70 / DP30 (Excellent) Hamamatsu (Good, 3 rd Party Driver) Evolucion (Excellent) Camera Support for Image-Pro Family * Image-Pro 6.X Support

18. Pricing ItemBundle de Image Pro Express 6Price OMC-1897Image Pro Analyzer$4000 OMC-1830Image Pro Plus (IPP6)$4799 OMC-1956 Image Pro Plus y Scope Pro (IPP-MC6)$5500 OMC-1857Image Pro Plus y ScopePro y AFA (IPP-MDA6)$8000 OMC-1846Image Pro Plus y 3DC y SharpStack (IPP-3DS)$8500 OMC-1897 OMC-1898 Image Pro Analyzer 3 copias$10,000 OMC-1949Image Pro Plus, SP, AFA, 3DC y SS (IPP-AMS6)$12,500

19. New Releases InVitro y InVivo

20. Multi Dimensional Acquisition

21. InVitro Multidimensional Acquisition and Analysis Count Size Extended Depth of Field

22. InVivo Acquisition Camera Control Fully Automated Microscope Control Multi Color Acquisition Time Lapse, Burst Acquisition 3D, z-series, Burst 3D with piezo Tiling, Mosaic, Slide and Well Scanning FRET Acquisition Optical Splitter Acquisition Live Ratio and Ca++ Imaging

23. Photometrics Family of Monochrome Cameras QImaging Family of Cameras (including MAC) Some Hamamatsu Cameras (not including Mac) Some Stanford Photonics Cameras Digital Camera Support

24. FRET Analysis FRET Acquisition Live Calibrated Ratio Display

25. Deconvolution, 3D Rendering & Measurement

26. Deblurring vs Deconvolution Auto-Quant® Algorithms are Used in Sharpstack The No Neighbor & Nearest Neighbor Algorithms are Deblurring Tools (Intensities are Removed) The Inverse Filter Algorithm is a Haze Restoration Tool (Intensities are Re-Assigned) The Optional 2D Blind and 3D Blind Tools are Deconvolution Algorithms (Intensities are Re- Assigned) The Sharpstack Algorithms are not Appropriate for Confocal Images Because They Use Widefield PSFs

27. Deblurring vs Deconvolution

28. AutoQuant X

29. Sequence Detection Loads Complex File Sequences Dynamically Changes to Accommodate Naming of Current File

30. Multi Time Point Load 3D Time Series Data Visualize, Deconvolve and Analyze as a Single Dataset

31. Multi Channel Load any Number of Channels Change Tints & Thresholds in Real-Time

32. Hierarchy of Algorithms 3D Blind Deconvolution – Premier 2D Blind Deconvolution – Live cell 3D Non-Blind - Faster for Derived PSFs 3D Non-Blind (Gold’s) – Fast but Noisy 3D Inverse Filter, Nearest/No Neighbor – Quick and Dirty

33. Deconvolution of Widefield and Confocal Images Primer on The Growing Role of Deconvolution…

34. Why Use Deconvolution? To Improve Signal to Noise Ratio

35. What is Deconvolution? Widefield – Single Channel

36. Multiple Wavelengths - Widefield

37. Confocal Microscopy

38. 2D Blind Deconvolution

39. 2D Blind Deconvolution – TIRF

40. When to Use Deconvolution? In Widefield Fluorescent Microscopy –Improve contrast of 2D and 3D Images –Improve Resolution in Three Dimensions –Improve 3D Rendering and Visualization

41. When to Use Deconvolution? In Confocal Microscopy –Improve Signal to Noise Ratios –Increase Dynamic Range –Improve Image Grayscale Resolution –Increase Axial Resolution

42. When to Use Deconvolution? Documentation –Images and Projections will Show More Detail and Greater Contrast –Improvements can be Striking

43. When to Use Deconvolution? Analysis –Deconvolution Retains Quantitative Accuracy –Improves Contrast Facilitating Analysis Counting Tracking Area Measurements Intensity Measurements

44. New Releases 3D Constructor

45. 3D User Options

46. 3D Rendering with 3D Filters

47. 3D Volume Measurements

48. 3D Volume Measurements Over Time

49. 3D Branch / End Point Measurements

50. New Releases IQbase 2

51. Top New Features of IQbase 2 IQbase 2 Features: Capture Module (Optional extra Cost) Support for Active Directory – Use Windows Identities for log-in and Security Levels Export Images and Data to PowerPoint Apply Measurements to Archived Images Compare Images Side-by-Side using Lightbox Tool Use 3D Scatterplots to Mine Data in Three Dimensions Speed Optimized for Analysis, Searching, Opening and Displaying New Manual Measurement Tools

52. IQbase 2 Powering Image Informatics Manages Images and Data Drives Discovery Facilitates Collaboration Easy to Use Works the Way You Do Grows with Your Organization (Scalable)

53. New Releases IQStudio 2

54. IQstudio Analytical Imaging Development Kit Rapid Development of Image Analysis Applications Develop Applications Using our Tools Add Image Analysis to Existing Products Standardize Image Analysis within the Organization Distribute Custom Applications with Run- Time Licensing

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