1. FERNE/EMRA ED Stroke Patient Management: What must we be able to do in order to provide tPA in the ED (mimickers, stroke scales, and CT interpretation)?

2. FERNE/EMRA EMRA Meeting ACEP SA New Orleans, LA October 15-18, 2006

3. FERNE/EMRA Edward P. Sloan, MD, MPH Professor Department of Emergency Medicine University of Illinois College of Medicine Chicago, IL

4. FERNE/EMRA Attending Physician Emergency Medicine University of Illinois Hospital Our Lady of the Resurrection Hospital Chicago, IL

5. FERNE/EMRA Disclosures NovoNordisk, King Pharmaceuticals, UCB Pharma Advisory BoardsNovoNordisk, King Pharmaceuticals, UCB Pharma Advisory Boards Eisai Speakers’ BureauEisai Speakers’ Bureau ACEP Clinical Policies CommitteeACEP Clinical Policies Committee ACEP Scientific Review CommitteeACEP Scientific Review Committee Executive Board, Foundation for Education and Research in Neurologic EmergenciesExecutive Board, Foundation for Education and Research in Neurologic Emergencies FERNE support by Abbott, Eisai, Pfizer, UCBFERNE support by Abbott, Eisai, Pfizer, UCB

6. FERNE/EMRA www.ferne.org

7. Key Clinical Questions You are obliged to be able to give tPA… You are obliged to be able to give tPA… What diagnostic skills? What diagnostic skills? What use of stroke scales? What use of stroke scales? What CT interpretation skills? What CT interpretation skills? What IV tPA use skills? What IV tPA use skills?

8. FERNE/EMRA Diagnostic Skills Identify a strokeIdentify a stroke Start with the Cincinnati stroke scaleStart with the Cincinnati stroke scale Identify speech and language deficitIdentify speech and language deficit Identify hemiparasisIdentify hemiparasis Identify CN deficits c/w strokeIdentify CN deficits c/w stroke Consider mental status changesConsider mental status changes

9. FERNE/EMRA Diagnostic Skills Exclude toxic/metabolic causesExclude toxic/metabolic causes Exclude seizure syndromesExclude seizure syndromes Exclude TIAsExclude TIAs Is the deficit significantly improving during the time that you are preparing to give IV tPA?Is the deficit significantly improving during the time that you are preparing to give IV tPA?

10. FERNE/EMRA Stroke Scales Use Estimate the severity of the strokeEstimate the severity of the stroke Know what patients were treated in the NINDS clinical trialsKnow what patients were treated in the NINDS clinical trials Be able to identify significant or moderate strokeBe able to identify significant or moderate stroke Consider use in elderly pts with severe stroke (NIHSS > 20) and AFibConsider use in elderly pts with severe stroke (NIHSS > 20) and AFib

11. FERNE/EMRA NIHSS: LOC LOC overall0-3 pts LOC overall0-3 pts LOC questions0-2 pts LOC questions0-2 pts LOC commands 0-2 pts LOC commands 0-2 pts LOC: 7 points total LOC: 7 points total

12. FERNE/EMRA NIHSS: Cranial Nerves Gaze palsy0-2 pts Gaze palsy0-2 pts Visual field deficit0-3 pts Visual field deficit0-3 pts Facial motor 0-3 pts Facial motor 0-3 pts Gaze/Vision/ Gaze/Vision/ Cranial nerves: 8 points total Cranial nerves: 8 points total

13. FERNE/EMRA NIHSS: Motor Each arm0-4 pts Each arm0-4 pts Each leg0-4 pts Each leg0-4 pts Motor: 8 points total Motor: 8 points total (8 right, 8 left)

14. FERNE/EMRA NIHSS: Cerebellar Limb ataxia0-2 pts Limb ataxia0-2 pts Cerebellar: 2 points total Cerebellar: 2 points total

15. FERNE/EMRA NIHSS: Sensory Pain, noxious stimuli0-2 pts Pain, noxious stimuli0-2 pts Sensory: 2 points total Sensory: 2 points total

16. FERNE/EMRA NIHSS: Language Aphasia0-3 pts Aphasia0-3 pts Dysarthria0-2 pts Dysarthria0-2 pts Language: 5 points total Language: 5 points total

17. FERNE/EMRA NIHSS: Inattention Inattention0-2 pts Inattention0-2 pts Inattention: 2 points total Inattention: 2 points total

18. FERNE/EMRA NIHSS Composite CN (visual):8 CN (visual):8 Unilateral motor:8 Unilateral motor:8 LOC: 7 LOC: 7 Language:5 Language:5 Ataxia:2 Ataxia:2 Sensory:2 Sensory:2 Inattention:2 Inattention:2

19. FERNE/EMRA Four Main NIHSS Areas CN/Visual:Facial palsy, gaze palsy, visual field deficit CN/Visual:Facial palsy, gaze palsy, visual field deficit Unilateral motor:Hemiparesis Unilateral motor:Hemiparesis LOC: Depressed LOC, LOC: Depressed LOC, poor responsiveness Language:Aphasia, dysarthria, neglect Language:Aphasia, dysarthria, neglect 28 total points 28 total points

20. FERNE/EMRA NIHSS ED Estimate CN (visual):8 CN (visual):8 Unilateral motor:8 Unilateral motor:8 LOC: 8 LOC: 8 Language/Neglect:8 Language/Neglect:8 Mild: 2, Moderate: 4, Severe: 8 Mild: 2, Moderate: 4, Severe: 8 +/- Incorporates other elements +/- Incorporates other elements

21. FERNE/EMRA NIHSS Patient Estimate CN/Visual: R vision loss, no fixed gaze 4 CN/Visual: R vision loss, no fixed gaze 4 Unilateral motor: hemiparesis 8 Unilateral motor: hemiparesis 8 LOC: mild decreased LOC 2 LOC: mild decreased LOC 2 Language:speech def, neglect 4 Language:speech def, neglect 4 Approx 18 points total Approx 18 points total Moderate to severe stroke range Moderate to severe stroke range

22. FERNE/EMRA CT Interpretation Skills No insular ribbon or MCA signNo insular ribbon or MCA sign No detailed assessmentNo detailed assessment Identify asymmetry and edemaIdentify asymmetry and edema Identify blood, mass lesionIdentify blood, mass lesion Identify any area of hypodensity c/w a recent stroke of many hours duration that precludes IV tPA useIdentify any area of hypodensity c/w a recent stroke of many hours duration that precludes IV tPA use

23. FERNE/EMRA xxxx

24. FERNE/EMRA

27. IV tPA Use Skills Identify indications, contraindications Quickly get the tests and consults Communicate with the neurologist Obtain consent with family and know what statistics are relevant Document the interaction Maintain BP below 185/110 range Follow the NINDS protocol closely

28. FERNE/EMRA ED tPA Documentation With tPA, there is a 30% greater chance of a good outcome at 3 months With tPA, there is a 30% greater chance of a good outcome at 3 months With tPA use, there is 10x greater risk of a symptomatic ICH (severe bleeding stroke) With tPA use, there is 10x greater risk of a symptomatic ICH (severe bleeding stroke) Mortality rates at 3 months are the same regardless of whether tPA is used Mortality rates at 3 months are the same regardless of whether tPA is used What was the rationale, risk/benefit assessment for using or not using tPA? What was the rationale, risk/benefit assessment for using or not using tPA? What was done to expedite Rx, consult neurology and radiology early on? What was done to expedite Rx, consult neurology and radiology early on?

29. FERNE/EMRAConclusions The IV tPA skill set is identified, limited, and manageable It is possible to provide quality emergency services with IV tPA Identify good patient candidates Make it happen quickly Document the ED management

30. FERNE/EMRA Questions? www.FERNE.org edsloan@uic.edu 312 413 7490 ferne_emra_2006_sloan_tpaskills_101506_finalcd 12/16/2015 5:17 PM