1. Online additional material Appendix Table 1: Medications Groups Appendix Table 2: Doctors' orders in hemodialysis units Additional Figure 1: Beta Blockers Additional Figure 2: Statins Additional Figure 3: Anti-arrhythmics Additional Figure 4: Nitrates Additional Figure 5: Doxazosin Additional Figure 6: Furosemide Additional Figure 7: Oral hypoglycemics Additional Figure 8: Antidepressants Additional Figure 9: Calcium Carbonate Additional Figure 10: Vitamin D analogs Additional Figure 11: Aspirin Additional Figure 12: Calcium Chanel Blockers Color coding for Additional Figures

2. Appendix table 1: Medications Groups. Number of patients who use the medication (No) Percent of patients wo use this drug (%) Antidepressants Mirtazapine, paroxetine, escitalopram, amitryptiline, fluvoxamine, escitalopram 1013.3 Doxazosin1317.3 Anti-arrhythmics Amiodarone, flecainide, propafenone 1317.3 Oral hypoglycemics Glibencamide, repaglinide, acrabose, metformin 1824.0 Nitrates Glyceryl trinitrate,Isosorbide mononitrate,Isosorbide dinitrate 2026.7 ACE inhibitors and ARB's* Captopril, ramipril, enalapril, losartan, cilazapril, valsartan 2736.0 Furosemide3242.7 Calcium Chanel Blockers Felodipine,amlodipine,nifedipine,verapamil,lercandipine 3344.0 Beta Blockers Metoprolol, Atenolol, Carvedilol, Bisoprolol 4661.3 Statins Simvastatin, Pravastatin, Atorvastatin 4965.3 Aspirin5370.7 Calcium Carbonate6789.3 Alfacalcidol6890.7 *Includes 4 cases of combined ARB's and Hydrochlorothiazide in one pill

3. Appendix Table 2: Doctors' orders in HD units All medications not including Calcium Carbonate and Alfacalcidol Calcium Carbonate AlfacalcidolAll Medications Start treatment711736124 Increase dose3846142227 Reduce dose323657125 Stop the treatment662246134 Switch to different drug of the same family23 Total230121281632

4. Figure 1 Plate A : Patients' Purchase Figure 5 Plate C : Adherence Figure 1 Plate B : Documentation By Nurses Figure 5 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 1: Beta Blockers - Medication purchase, reporting and adherence patterns

5. Figure 2 Plate A : Patients' Purchase Figure 2 Plate C : Adherence Figure 2 Plate B : Documentation By Nurses Figure 2 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 2: Statins – Medication purchase, reporting and adherence patterns

6. Figure 3 Plate A : Patients' Purchase Figure 3 Plate C : Adherence Figure 3 Plate B : Documentation By Nurses Figure 3 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 3: Anti-arrhythmics – Medication purchase, reporting and adherence patterns

7. Figure 4 Plate A : Patients' Purchase Figure 4 Plate C : Adherence Figure 4 Plate B : Documentation By Nurses Figure 4 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 4: Nitrates- Medication purchase, reporting and adherence patterns

8. Figure 5 Plate A : Patients' Purchase Figure 5 Plate C : Adherence Figure 5 Plate B : Documentation By Nurses Figure 5 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 5: Doxazosin- Medication purchase, reporting and adherence patterns

9. Figure 6 Plate A : Patients' Purchase Figure 6 Plate C : Adherence Figure 6 Plate B : Documentation By Nurses Figure 6 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 6: Furosemide- Medication purchase, reporting and adherence patterns

10. Figure 7 Plate A : Patients' Purchase Figure 7 Plate C : Adherence Figure 7 Plate B : Documentation By Nurses Figure 7 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 7: Oral hypoglycemics – Medication purchase, reporting and adherence patterns

11. Figure 8 Plate A : Patients' Purchase Figure 8 Plate C : Adherence Figure 8 Plate B : Documentation By Nurses Figure 8 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 8: Antidepressants – Medication purchase, reporting and adherence patterns

12. Figure 9 Plate A : Patients' Purchase Figure 9 Plate C : Adherence Figure 9 Plate B : Documentation By Nurses Figure 9 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 9: Calcium Carbonate Medication purchase, reporting and adherence patterns

13. Figure 10 Plate A : Patients' Purchase Figure 10 Plate C : Adherence Figure 10 Plate B : Documentation By Nurses Figure 10 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 10: Vitamin D analogs- Medication purchase, reporting and adherence patterns

14. Figure 11 Plate A : Patients' Purchase Figure 11 Plate C : Adherence Figure 11 Plate B : Documentation By Nurses Figure 11 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 11: Aspirin – Medication purchase, reporting and adherence patterns

15. Figure 12 Plate A : Patients' Purchase Figure 12 Plate C : Adherence Figure 12 Plate B : Documentation By Nurses Figure 12 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 12: Calcium Chanel Blockers- Medication purchase, reporting and adherence patterns