2. gbn.glenbrook.k12.il.us/academics/science/Staff/cooper/THE%20BIG%204%20JOURNAL%20PACKET.doc Slides used and modified from:

3. Before you can understand the topics in this unit there are some key vocabulary terms you need to know. MacromoleculePolymerMonomer

5. What do these words mean?

6. So What Is A Macromolecule? You should be able to define it on your own !

7. Next Word…..

8. Polygons Polygamy Polyester

10. What does “Mono” mean?

11. A Polymer Here are some analogies to better understand what polymers and monomers are…. EXAMPLE of POLYMER MONOMER A TRAIN? A SENTENCE? If the train is the whole polymer, what would be the small groups that make up the train? If the sentence is the polymer, what are the monomers that make up the sentence?

12. A Polymer Here are some analogies to better understand what polymers and monomers are…. EXAMPLE of POLYMER MONOMER A TRAINEACH RAILCAR A SENTENCEEACH WORD If the train is the whole polymer, what would be the small groups that make up the train? If the sentence is the polymer, what are the monomers that make up the sentence?

13. Now you and a buddy need to think of at least 2 other analogies for a polymer and its monomers.

16. Three out of the 4 types of biochemical macromolecules can be found on food nutrition labels…

17. Look at the label to the left. 3 of the 4 macromolecules can be found in foods. The 3 biochemical molecules found on a nutrition label are: 1____________________ 2____________________ 3____________________ (0 grams in this product) (13 grams in this product) (9 grams in this product)

19. The 4th type of biochemical macromolecules are the NUCLEIC ACIDS The types of Nucleic Acids –DNA (DeoxyriboNucleic Acid) –RNA (RiboNucleic Acid)

20. “DNA” is short for DeoxyriboNucleic Acid Now you know why they just call it DNA!

21. When studying these biochemical molecules, we are interested in finding out….. what they do for living things. what they generally look like. what their monomers are. and how they may help the body gain energy to sustain life.

22. Keep the following in mind when studying this material: Nucleic AcidsWhat they look like CarbohydratesWhat they do/Where are they LipidsWhat are they made up of- at the level of atoms Proteins

23. LET’S BEGIN WITH CARBOHYDRATES They are the main source for the body to gain energy. They are our fuel! They make up the cell wall in plants which allow them to grow tall, without this carbohydrate, a plant would be a mushy mess! This type of carbohydrate is called Cellulose. THINK: CARBS= ENERGY and CELL WALLS

24. CARBOHYDRATES In plant foods- in the cell walls of plants --- in fruits, vegetables, peas, beans, SUGAR comes from a plant and so does FLOUR! (pasta, potatoes, bread, candy, cookies)In plant foods- in the cell walls of plants --- in fruits, vegetables, peas, beans, SUGAR comes from a plant and so does FLOUR! (pasta, potatoes, bread, candy, cookies)--------------------------------------------------- In animal products- in MILKIn animal products- in MILK

25. CARBOHYDRATES THERE ARE 2 TYPES OF CARBOHYDRATES Simple Complex

26. Simple Sugars are carbohydrates made up of 1 or 2 monomers. They also taste sweet.

27. Simple Sugars

28. Complex Carbohydrates… What are they? Complex Cabohydrates are polymers made up of many monomers. Most also taste starchy.

29. Complex Carbohydrates

30. CARBOHYDRATES Carbohydrates are chains (polymers) made of monomers. The most common monomer of carbohydrates is…

31. The shape of Glucose is a hexagonal ring

32. CARBOHYDRATES Each carbohydrate is made up of… THINK: “CHO”

33. NOW ONTO PROTEINS They are the major structural molecules in living things for growth and repair : muscles, ligaments, tendons, bones, hair, skin, nails…IN FACT ALL CELL MEMBRANES have protein in them They make up antibodies in the immune system They make up enzymes for helping chemical reactions They makeup non-steriod hormones which THINK: Proteins= membranes, enzymes, antibodies, non- steriod hormones, structural molecules, “MEANS”

34. MORE ON PROTEINS… The following slides give you a little more in depth info on things that are made of proteins…

35. Muscles, ligaments, tendons, and bones Without these particular structural proteins, we would look more like this….

36. Well, maybe not exactly…

37. Hair, Skin, and Nails

38. Microscope View of Skin and Nails This is skinThis is a nail

39. Cell Membrane The cell membrane surrounds everything in a cell so it doesn’t leak out. It is kind of like the balloon in a water balloon. The cell membrane is made mostly of protein AND lipids.

40. Antibodies are part of the immune system. When something enters the body that isn’t supposed to be there, like certain bacteria, antibodies find the invader and stick themselves onto it. When a white blood cell finds the invader covered with antibodies, it knows it doesn’t belong there and kills it.

41. Enzymes are proteins that speed up chemical reactions. If you didn’t have enzymes in your stomach to speed up digestion, the food would rot in your stomach because it would take so long!

42. Hormones are chemicals made in glands that are in one place in the body and then put into the blood to be used in another. These are where the hormone producing glands are located in your body.

43. The thyroid is found in the middle of your neck, by your voice box. Here is a picture of those cells secreting the thyroid hormone. Thyroid hormone regulates how fast your body uses energy. If you have an over active thyroid, you use energy quickly and tend to be very thin and have a hard time putting on weight. If you have an under active thyroid gland, you use energy very slowly and tend to carry more body fat and have a difficult time losing it. Don’t be quick to think you have a thyroid problem if you are overweight, chances are it’s actually your eating and exercise habits! (The yellow stuff is thyroid hormone)

44. PROTEINS In plant foods- in the cell membranesIn plant foods- in the cell membranes In animal products- in the cell membranes- in the muscles or living things- cows, chicken, fish…In animal products- in the cell membranes- in the muscles or living things- cows, chicken, fish…

45. Proteins

46. Aside from the protein found in animal sources…protein can also be found in fruits, vegetables, grains, and nuts. (it just does not have as many amino acids)

47. PROTEINS Proteins are made of long chains (polymers) made of monomers. All proteins are made of the monomer…

48. http://www.hcc.mnscu.edu/programs/dept/chem/V.27/amino_acid_structure_2.jpg

49. http://upload.wikimedia.org/wikipedia/commons/thumb/c/c5/Amino_acids_2.png/483px-Amino_acids_2.png

50. The shapes of proteins are like a balled up piece of string Amino Acid chain All wound up

51. PROTEINS Each protein is made up of… THINK: “CHONS”

52. Proteins and Fragile X

53. Voles

54. LIPIDS ARE NEXT They are a great source of STORED ENERGY so we have it in the future. They INSULATE the body to maintain normal body temperature and they CUSHION the internal organs for protection. They produce hormones for the body called STERIODS They waterproof surfaces of animals,plants, and fruits- these are waxes! THINK: Waterproof, insulate, steriods, energy, cushion… “WISE C”

55. LIPIDS…Some interesting info Fruits produce a waxy coating to keep from drying out. The cells in a tulip make a wax which helps coat the leaves. Ear wax traps dust, sand, and other foreign particles from going deeper into the ear and causing damage. Beeswax- a structural material to hold honey in the hive

56. LIPIDS…Some interesting info There are many different types of steroids. They are all lipids. Their functions vary. Some common steroids are: SEX STEROIDS ANABOLIC STERIODS CHOLESTEROL Like testosterone and estrogen They increase muscle

57. LIPIDS…Some interesting info Some anabolic steroids are illegal And can be dangerous and very unhealthy NATURAL STERIODS IN OUR BODY INCREASE MUSCLE GROWTH AND BONE DEVELOPMENT AND ARE GOOD. THE ILLEGAL ONES THAT ARE SYNTHETIC ARE BAD.

58. Very Common Effects of Illegal Steroids If used when the person is still growing, they will be shorter as an adult, anabolic steroids will decrease bone growth. Males will experience shrinking of the testicles, and with prolonged use, the steroid will be turned into estrogen in the male body and it will start to lay fatty tissue on the chest, otherwise known as breasts. If genetically predisposed to becoming bald, balding will happen more quickly. If clean needles are not readily available, there is a significantly higher risk of getting AIDS. Future risks of liver cancer & disease. Enlarged heart which can lead to death

59. Illegal Steroid Use in Women Some additional effects… Breasts will decrease in size, the opposite of what happens to men. The woman will start to grow facial hair, how quickly depends on her genetic makeup. If she discontinues use, the facial hair will still continue to grow. If she is genetically predisposed to balding, she will start to lose her hair, just as if she was genetically male. Her voice will start to deepen, how quickly depends on her genetics. If she discontinues use, her voice will remain deep.

60. LIPIDS In plants- in the seedsIn plants- in the seeds--------------------------------------------------- In animals- in adipose tissue, connective tissue, in animalsIn animals- in adipose tissue, connective tissue, in animals--------------------------------------------------- Lipids make up the cell membrane of all cells.Lipids make up the cell membrane of all cells.

61. LIPIDS

62. Lipids are chains (polymers) made of monomers. The most common monomer of lipids is… (1 glycerol + 3 fatty acids)

63. The Shape of a triglyceride is like the letter E This is a triglyceride molecule

64. Saturated Fatty Acids have no double bonds and are saturated with hydrogen. Unsaturated Fatty Acids have double bonds. www.agen.ufl.edu/~chyn/age2062/lect/lect_02/3_16.gif

65. Cis and Trans Fatty Acids http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/cis_trans.gif

66. Cis –vs-Trans Shapes http://www.mansfield.ohio-state.edu/~sabedon/047cis.gif

67. LIPIDS Each carbohydrate is made up of… THINK: “CHO”

68. OH NO CHO! Lipids like Carbs? You might have noticed that both carbohydrates and lipids have the elements Carbon, Hydrogen, and Oxygen. “CHO” A carbohydrate, has twice as many hydrogen atoms as the number of oxygen atoms. EX: C 6 H 12 O 6 (This is a carb= there are double the number of H compared to O) On the other hand, lipids have a lot more than twice the amount hydrogen atoms as the number of oxygen atoms. EX: C 27 H 46 O cholesterol

69. Quick Review Questions What Big 4 molecule stores energy for the future? What are 4 effects of illegal steroid use in men and 3 effects in women? What are 4 things proteins do in your body? What are the functions of lipids? What is the main function of carbohydrates?

70. Mini Quiz Examples of the Big 4 Each of the following foods is high in one of the Big 4 organic molecules. Decide which one for each of the following foods. –Corn Oil –Lean Ham –Bread –Fish

71. FINALLY- NUCLEIC ACIDS

72. NUCLEIC ACIDS THERE ARE 2 TYPES OF NUCLEIC ACIDS DNA RNA

73. Nucleic Acids 1)DNA Is our genetic material. Chromosomes are made of DNA. Chromosomes contain the “recipes” to make proteins for your body. 2)RNA Reads the DNA “protein recipes” and makes the proteins for your body.

74. NUCLEIC ACIDS In plants- inside the nucleus of the cellsIn plants- inside the nucleus of the cells ------------------------------------------------------------------------------------------------------ In animals- inside the nucleus of each cellIn animals- inside the nucleus of each cell ------------------------------------------------------------------------------------------------------

75. NUCLEIC ACIDS

76. Nucleic Acids are chains (polymers) made of monomers. Nucleic acids are made up of Which are nitrogen bases…something we will learn more about when we study DNA

77. The shape of a nucleic acid is:

78. Nucleic Acids Each nucleic acid is made up of… THINK: “PONCH”

79. ENERGY Three of the BIG 4 provide us with energy through the food we eat: BIG 4 MACROMOLECULES Number of Calories it provides Carbohydrates Proteins Lipids Nucleic Acids

80. ENERGY Energy that is gained by consuming food is called a

81. Energy that we gain by the consumption of food is measured in Calories. If you drink a glass of skim milk, you will get a gain of 90 Calories of energy for your body.

82. Energy Gained From Carbohydrates Eating 1 gram of carbohydrate provides your body with 4 Calories.

84. Energy Gained from Lipids Eating 1 gram of fat provides your body with 9 Calories. Notice if you eat 1 gram of fat, you are gaining more than twice the amount of Calories than from a gram of carbohydrate or protein!

85. Nucleic acids The nucleic acids in food are not considered a substance that the body uses to gain energy.

86. ENERGY So… BIG 4 MACROMOLECULES Number of Calories it provides Carbohydrates4 Proteins4 Lipids9 Nucleic Acids0 TEST: TEST: Are you smart? If you eat a sandwhich with 46 grams of carbs and 24 grams of protein and 10 grams of fat, how much energy will you gain?

87. What elements are found in all of the Big 4 molecules? Which of the Big 4 has different elements and what are they? Since Carbohydrates and Lipids have the same elements in them, how can you tell the difference? Would C 26 H 32 O 5 be a carbohydrate or lipid? Which molecule is in the shape of a hexagon? Which molecule is in the shape of an E? A polymer of amino acids makes what molecule?

88. What kind of carbohydrate gives you a quick burst of energy? What kind of carbohydrate gives you long term energy? You are stranded on a desert island and have found a box of food. Considering you have almost nothing to eat on the island, which of the following would be the best food to have in the box? WHY? –Crackers –Butter –Steak How many Calories are found in 1 gram of protein? How many Calories are in 1 gram of nucleic acid?

89. Final Review Questions Please do not look back at the information in your handout until you have answered all of the following questions. 1. What are 2 examples of simple sugars and 2 examples of complex carbohydrates not mentioned already? 2. What is a polymer? 3. What is a monomer? 4. Carbohydrates are the body’s main source of ________________. 5. Define in your own words: Biochemical Macromolecule 6. Proteins are major structural molecules in living things. List 5 places or things in your body that contain a lot of protein. 7. What are enzymes? What are they made of? 8. What are hormones? 9. What does your thyroid hormone do? 10. Name three types of proteins. 11. What are the functions of lipids? 12. What elements are found in each of the Big 4 molecules? 13. What does DNA do? RNA? 14. How many Calories are found in 1 gram of each of the Big 4 molecules? 15. What are 5 possible effects of illegal steroid use? 16. What are 3 functions of lipids? 17. What is the function of waxes? 18. What are 2 ways simple sugars are different from complex carbohydrates? 19. What are 4 organic macromolecules?

90. Name that MACROMOLECULE! Pick up your response boards

91. Which one of the following molecules is a lipid? A carbohydrate? 1.) C 27 H 46 O 2.) C 12 H 24 O 12 Lipid Carbohydrate

92. Provides the body with Stored Energy lipids

93. carbohydrate

94. “PONCH” Nucleic Acid

95. Are found in the cell membranes of all cells lipidprotein

96. Are found in the nucleus of plant and animal cells Nucleic Acid

97. Has the monomer called triglyceride (glycerol & 3 fatty acids) lipids

98. Nucleic Acid

99. Provides the hormone called Steroids lipid

100. “CHO” Twice as many hydrogens as oxygens carbohydrates

101. Has the monomer called glucose carbohydrates

102. “CHO” More than twice as many hydrogens as oxygens lipid

103. The main source of energy for the body carbohydrates

104. Produces non- steroid hormones and antibodies for the body (builds and repairs) protein

105. lipid

106. The genetic material for all living things Nucleic Acids

107. “CHONS” protein

108. Responsible for the instructions to create proteins for the body Nucleic Acid

109. also referred to as FATS lipids

110. protein