1. This is a work in progress! Subject to change in content and points offered for each section! Further discussion in class will clarify details! PROJECT DUE DATE AND PRESENTATION: FRIDAY, OCTOBER 24 TH.

2. Biobank Brochure ~rubric and example PROJECT DUE DATE AND PRESENTATION: FRIDAY, OCTOBER 24 TH.

3. Additional Information: Amy Albritton Honor’s Anatomy and Physiology Prattville High School April 4, 2014 amy.b.albritton@acboe.net (adrenoleukodystrophy) Lorenzo’s Oil Refinery “a bootleg company” ALD http://ghr.nlm.nih.gov/search?query http://omim.org/entry/300100 http://www.childrenscancer.org behavioral changes poor memory and poor school performance visual loss, seizures, deafness difficulties with speechswallowing and coordination Fecal and urinary incontinence Cerebral demyelination and inflammation SYMPTOMS Contact Information

4. PAGE 3 (Cover Page) PAGE 2 (Back of Brochure) PAGE 1 Front side of sheet…

5. I.Page 1 (Front Side of Sheet): a.Bullet these. List reasons WHY someone should choose this biobank. b.Pictures (at least three) II.Page 2: Back of Brochure: (Front Side of Sheet): 1.Additional Resources: This is where you will list your sources for pictures, ideas, text, quote Must have at least three. One source must be your satisfied customer for the testimonial quote/short story. Write them using MLA citation format 2.Contact Information: a.) Your name b.) Honor’s Genetics c.) Period d.) Prattville High School e.) Date III.Page 3: Front Cover of Brochure: (Front Side of Sheet) a.Name of facility, center, or program b.“Slogan” c. Logo d.Picture/artwork Front side of sheet… PAGE 1 PAGE 3 PAGE 2

6. affects all ethnic groups most common inherited leukodystrophy minimum incidence ranging from 1:42,000 untreated, ALD will cause death in three to five years progression can be stabilized no cure yet Our Research Treatment Plan: What does it do to the CNS? mutation in the ABCD1 gene What causes ALD? X-linked recessive genetic disorder that affects males. ‘adreno’ refers to the adrenal glands; ‘leuko’ refers to the white matter of the brain, and ‘dystrophy’ means abnormal growth or development. A peroxisomal disease damages the myelin sheath on neurons no production of protein that helps break down fatty acids accumulation of the saturated very long chain fatty acids in all body tissues. What is Adrenoleukodystrophy? bone marrow transplant intravenous mesenchymal stem cells during the period before the transplant high-dose antioxidant therapy provide families with emotional support, networking opportunities, and other kinds of assistance Adrenal steroid replacement therapy Hematopoietic stem cell transplantation gene therapy allogeneic hematopoietic stem cell transplantation (HSCT) “When we found out that all three of our boys, Owen, Dylan and Jacob, had it, we were devastated.” Darlene, mother of the boys PAGE4 PAGE 5 PAGE 6

7. PAGE 5 PAGE 4 Back side of sheet…

8. PAGE 4PAGE 6 PAGE 5 Back side of sheeT Requirements IV.Page 4 (Back of Sheet): a.What is a biobank? b.5 Requirements to be a legitimate biobank……. (bullet these) c.Why do we need a biobank? d.Pictures e.Describe the process of using/making use of the biobank? (scientific explanation) V.Page 5 (Back Side of Sheet): a.Our Services Offered -Bullet these and describe. Stick to the most common. b.Pictures/artwork-(of options- equipment, indiv. items, diagrams, artwork) VI.Page 6 (Back Side of Sheet): a.The Research - the following are suggestions……… Bullet these % of population represented in database #1 service requested #1 method of extracting target cells and tissues Side effects or warnings of procedures Possibility of a Cure for genetic disorders? Names of disorders biobank is concerned with…. bullet b.Pictures (at least two) c.Testimonial/Quote/Short story Personal Testimony/Quote/short story from satisfied customer Picture- (person giving testimony/quote/story)

9. PROJECT DUE DATE AND PRESENTATION: FRIDAY, OCTOBER 24 TH.