1. Grant Writing – Approach What if you don’t get anticipated results? Limitations Timeline Emelia J. Benjamin, MD, ScM The NHLBI’s Framingham Heart Study Boston University School of Medicine No industry relationships to disclose ♥2R01HL092577 ♥1P50 HL120163 ♥N01-HC 25195

2. Approach Order – Elements Rationale Hypothesis Preliminary results Methods ­Sample ­Design ­Statistical analysis ­Power Anticipated results Possible problems and potential solutions Read grant from paragraph headings

3. Approach Expected Outcomes Outline for each aim Purpose ­Synthesizes each of the aim’s outcomes ­Reinforces how aim advances field – ROI ­Provides reviewer reassurance that you have back up plan if outcome not met

4. Approach Potential Problems Alternative Strategies Purpose ­Demonstrates awareness of limitations ­Resilience ­Types of problems  Generalizability  Multiple testing  Misclassification  Confounding  Over-adjusting  Changing technology  Temporality  Bias  Causality  Specific assay  Correct model  Enrollment problems

5. Approach Timeline Purpose ­Gives reviewers perspective/flow of work Pitfalls ­Illogical sequence ­Not grounded in Specific Aims ­Over-ambitious ­Under-ambitious ­Absent timeline