1. Dengue fever

2. Dengue fever

3. Pengertian dengue fever
Dengue (DF) and dengue hemorrhagic fever (DHF) are caused by one of four closely related, but antigenically distinct, virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4), of the genus Flavivirus.
Infection with one of these serotypes provides immunity to only that serotype for life, so persons living in a dengue-endemic area can have more than one dengue infection during their lifetime.

4. DF and DHF are primarily diseases of tropical and sub tropical areas, and the four different dengue serotypes are maintained in a cycle that involves humans and the Aedes mosquito.

5. However, Aedes aegypti, a domestic, day-biting mosquito that prefers to feed on humans, is the most common Aedes species.
Infections produce a spectrum of clinical illness ranging from a nonspecific viral syndrome to severe and fatal hemorrhagic disease.
Important risk factors for DHF include the strain of the infecting virus, as well as the age, and especially the prior dengue infection history of the patient.

6. No dengue vaccine is available.

7. Beberapa pengertian
Endemic - means a disease occurs continuously and with predictable regularity in a specific area or population .
Epidemic - a widespread outbreak of an infectious disease where many people are infected at the same time.
Outbreak - an epidemic limited to localized increase in the incidence of a disease, e.g., in a village, town, or closed institution
Pandemic - an epidemic occurring worldwide, or over a very wide area, crossing international boundaries, and usually affecting a large number of people.

8. Recombinant vaccine - using the technique of recombination to create an attenuated virus which elicits an immune response against the viral strain of interest in order to use as a vaccine in humans.
Seroytpe - a closely related set of viruses that can be differiented by the immune response they produce. 
Viral envelope gene sequence - the nucleic acid composition in the envelope gene