1. Overview of the Harvard Catalyst Imaging program ClareTempany, MD; Ron Kikinis, MD; Valerie Humblet, PhD http://catalyst.harvard.edu April 9, 2009

2. Agenda 1 Harvard Catalyst Imaging Consortium Technology and Expertise IT Structure Why be a consultant ? Educational Opportunities Contact

3. Harvard Catalyst: The History and the Basics 2 GCRC program (20+ yr NCRR/NIH funded clinical trials program) discontinued –BWH/MGH imaging cores (CT/AVD/GS) CTSA 2007(Roadmap initiative- EAZ ) HU- Response-Harvard Catalyst –(PI Lee Nadler/Co-Director: Steve Freedman) –GCRC replaced by PCIR We are a pan-Harvard enterprise dedicated to improving human health by: –Creating Connections –Enabling research At the Cutting Edge of discovery –Nurturing clinical and translational researchers

4. National Effort in C/T Research 38 AHC/23 states 3 Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium-14 new in 08 Source: http://www.ctsaweb.org/ Duke Mayo Clinic Cornell J.Hopkins UC Davis Wash. U. Northwestern Emory U. Imaging programs-(Dan Sullivan/RSNA)

5. Institutions participating in Harvard CTSC 4 Academic Healthcare Centers Beth Israel-Deaconess Medical Center Brigham and Women’s Hospital Massachusetts General Hospital Children’s Hospital Boston Specialty Hospitals and Institutes Dana-Farber Cancer Institute Forsyth Dental Institute Joslin Diabetes Center Massachusetts Eye and Ear Infirmary McLean Hospital Schepens Eye Research Institute Massachusetts Institutes of Technology Harvard University Faculty of Arts and Sciences Harvard Business School Harvard School of Dental Medicine Harvard Divinity School Graduate School of Design Graduate School of Education Kennedy School of Government Harvard Law School Harvard Medical School Harvard School of Public Health Harvard School of Engineering Community Healthcare Institutions Cambridge Health Alliance HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare Red –Imaging Consortium Year 01 total budget: $22,148,106

6. Harvard catalyst Programs (Selected list) –Biomedical Informatics-Kohane –Community engagement –Design and Biostats –Dev of Novel CT methodologies-Vikas –Diversity/Health Disparities research –Ethics –Linkages-HL, HBS, Kennedy School etc –Pilot studies –Regulatory-BB –Research Education 5

7. Harvard catalyst Programs –Translational Technologies and Resources (TTR)-Gordon Williams (Imaging) –increases investigator awareness and utilization of established translational technologies, educates the research community in the underlying principles and application of relevant translational technologies and fosters collaborations to improve these technologies. 6

8. Pilot funds Eligibility: All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation. Funds: Pilot Grants will be awarded in the amount of $50,000, with an award period of one year. Deadlines: Letter of intent: May 13, 2009 Full application: June 12, 2009 Contact: Harvard Catalyst Research Navigators 617 432-7800 7

9. Bruce Rosen, Director Randy Gollub, Co-Director Gordon J. Harris, Site Co-Director Robert Lenkinski, Site Co-Director Neil Rofsky, Site Co-Director Clare Tempany, Site Co-Director Ron Kikinis, Site Co-Director Gordon Williams, PI for CTSC Translational Technologies Stephan Voss, Site Co-Director Simon Warfield, Site Co-Director Annick D. Van den Abbeele, Site Co-Director Jeff Yap, Site Co-Director Gordon J. Harris, Site Co-Director Annick D. Van den Abbeele, Site Co-Director William Hanlon, Core Manager Valerie Humblet, Imaging Liaison Yong Gao, XNAT Engineer Imaging Consortium Team 8

10. Mission of the Imaging Consortium 9 Expand imaging in clincial research –To build infrastructure Provide expert consultation and guidance to CTSC participants in the use of imaging as part of clinical translational research IT framework Educate and advise Harvard and the Affiliated Academic Health Centers about available imaging, techniques, capabilities and image processing capabilities in the Harvard environment.

11. Harvard Catalyst website 10 Access to resources and profiles http://catalyst.harvard.edu/home.html

12. Image Consortium Consultation Service 11 Access to the consultation service: http://catalyst.harvard.edu/home.html

13. Technologies and Expertise 12 Cancer imaging, MRI, PET, CT, fMRI, pediatric imaging, neuroimaging. Focused on assisting with planning and design of research proposals and/or methods for image analysis. Consultation is available for the preparation of a grant or IRB submission. We do not provide ongoing support for the implementation of new studies or the analysis of data from existing studies.

14. Imaging Consultation Service 13 Investigator fill webform on Catalyst website –Name, institution, nature research, reason for consult Medical Imaging Liaison –dispatches request to the imaging consortium –Follow-up with investigator Consultations discussed weekly Designated consultant contacts investigator

15. Becoming an Imaging Consultant 14 Potential benefits of being an active collaborator : –Good framework for research –Research opportunities through collaborations –Meeting experts out of radiology –Networking with imaging cores outside of Boston Examples: –Standardization of physiologic monitoring system for fMRI –Development lingual nerve imaging (MGH-BIDMC) –Study of brain-development in premature infants (CHB- BWH-MGH) –Liver inflammation –Cardiac conductivity study

16. Educational Opportunities proposal 15 Nanocourse: –Imaging 101 to increase knowledge about imaging More advanced classes for radiologists: –Tumor metrics –Radiation safety issues for IRB submission –Hands-on classes on data analysis –Imaging perfusion –Example: www.na-mic.org/Wiki/images/8/8b/Slicer3Training_ChangeTracker.ppt

17. XNAT-PACS-i2b2 Integration 16 IT Catalyst infrastructure: –i2b2: scalable computational framework to help translation of genomic findings. –BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups. –NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: slicer. Freesurfer.

18. XNAT Enterprise Data Repository (CRC) File Repository Identity Management Ontology Management Correlation Analysis De - Identification Of data Natural Language Processing Annotating Genomic Data #1 Project Management Workflow Framework Annotating Genomic Data #2 PACS i2b2 HIVE Dr X Desktop Pediatric rare disease Dr Y Desktop Alzheimer Dr Z Desktop Chronic pain management Dr W Desktop Quantitative cancer biomarkers XNAT-PACS-i2b2 Integration 17 Slicer: Data visualization analysis

19. Invitation Please consider getting involved –Info- Google Harvard catalyst –Pls sign up as a potential consultant today! –Pilot grants (est x2 application dates per year) –Watch your email- attend meetings symposiums to meet new research colleagues 18

20. 19 http://catalyst.harvard.edu Image_Consult@catalyst.harvard.edu www.na-mic.org/Wiki/index.php/Collaboration:Harvard_CTSC