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Beckett N, Peters R, Tuomilehto J, et al. Immediate and late benefits of treating very elderly people with hypertension: results from active treatment.

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Presentation on theme: "Beckett N, Peters R, Tuomilehto J, et al. Immediate and late benefits of treating very elderly people with hypertension: results from active treatment."— Presentation transcript:

1 Beckett N, Peters R, Tuomilehto J, et al. Immediate and late benefits of treating very elderly people with hypertension: results from active treatment extension to Hypertension in the Very Elderly randomised controlled trial BMJ. 2012;344:d7541 doi: 10.1136/bmj.d7541 (Published 4 January 2012) HYVET 1-year extension: Immediate and late benefits with indapamide SR ± perindopril in the treatment of hypertensive patients.

2 HYVET 1-year extension 1 Study protocol 3.1 years on active treatment 1 year on active treatment n= 3845 patients n= 1712 patients Placebo Indapamide SR ± perindopril Indapamide SR ± perindopril Indapamide SR ± perindopril 2.1 years 1-year extension 2.1 years 1. Beckett N, Peters R, Tuomilehto J, et al. BMJ 2012;344:d7541 doi: 10.1136/bmj.d7541 (Published 4 January 2012) vs.

3 HYVET 1 Results n= 3845 patients Placebo Indapamide SR ± perindopril 2.1 years Stroke hazard ratio: -39% P =0.05 in favor of the indapamide SR ± perindopril group. Heart failure hazard ratio: -64% P<0.001 in favor of the indapamide SR ± perindopril group. All-cause mortality hazard ratio: -21% P=0.02 in favor of the indapamide SR ± perindopril group. 1. Beckett NS, Peters R, Fletcher AE, et al. N Engl J Med. 2008;358:1887-1898. Cardiovascular events hazard ratio: -34% P<0.001 in favor of the indapamide SR ± perindopril group. Cardiovascular mortality hazard ratio: -23% P=0.06 in favor of the indapamide SR ± perindopril group. vs.

4 HYVET 1-year extension 1 Study protocol 3.1 years on active treatment 1 year on active treatment n= 3845 patients n= 1712 patients Placebo Indapamide SR ± perindopril Indapamide SR ± perindopril Indapamide SR ± perindopril 1. Beckett N, Peters R, Tuomilehto J, et al. BMJ 2012;344:d7541 doi: 10.1136/bmj.d7541 (Published 4 January 2012) 2.1 years 1-year extension vs.

5 No significant difference between the two arms in: - Stroke P=0.28 - Heart failure P=0.28 - Cardiovascular events P=0.55 HYVET 1-year extension 1 Results Indapamide SR ± perindopril provides patients with immediate protection against stroke, heart failure, and cardiovascular events These benefits appeared within 1 year of starting treatment Indapamide SR ± perindopril provides patients with immediate protection against stroke, heart failure, and cardiovascular events These benefits appeared within 1 year of starting treatment n= 3845 patients n= 1712 patients Placebo Indapamide SR ± perindopril Indapamide SR ± perindopril Indapamide SR ± perindopril 2.1 years 1-year extension 1. Beckett N, Peters R, Tuomilehto J, et al. BMJ 2012;344:d7541 doi: 10.1136/bmj.d7541 (Published 4 January 2012) vs.

6 Indapamide SR ± perindopril provides cumulative time-dependent life-saving benefits, increased over the long term. Total mortality hazard ratio: -52% P =0.02 in favor of the group treated for 3.1 years. Cardiovascular mortality hazard ratio: -81% P =0.03 in favor of the group treated for 3.1 years. n= 3845 patients n= 1712 patients Placebo Indapamide SR ± perindopril Indapamide SR ± perindopril Indapamide SR ± perindopril 2.1 years 1-year extension HYVET 1-year extension 1 Results 1. Beckett N, Peters R, Tuomilehto J, et al. BMJ 2012;344:d7541 doi: 10.1136/bmj.d7541 (Published 4 January 2012) vs.

7 Indapamide SR ± perindopril provides cumulative time-dependent life-saving benefits, increased over the long term. HYVET 1-year extension 1 Results 1. Beckett N, Peters R, Tuomilehto J, et al. BMJ 2012;344:d7541 doi: 10.1136/bmj.d7541 (Published 4 January 2012) Total mortality Cardiovascular mortality P=0.02 P=0.03 -52% -81%

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