1. Steven Gollmer Cedarville University Complex Life: Page 1 HON-3230 Chance, Emergence or Design Origin of Complex Life

2. Steven Gollmer Cedarville University Complex Life: Page 2 From a Simple Replicator Life requirements –Information storage –Replication –Metabolism Possible first replicators –Protein first world –RNA world –Lipid world –Metabolism first

3. Steven Gollmer Cedarville University Complex Life: Page 3

4. Steven Gollmer Cedarville University Complex Life: Page 4 Metabolism Recapitulates Biogenesis –Central Metabolic cycle (A) Basic replication Pathway for fatty acid production –Amino acid production (B) Synthesis involving nitrogen –Basis for protein structure (C) Synthesis involving sulfur –Basis for nucleic acid and coenzymes (D) Synthesis involving ring closure

5. Steven Gollmer Cedarville University Complex Life: Page 5 Two Ways to Model the Essentials Bottom-Up (Modification by co- option) Top-Down (Interoperating components) A B C O H N S C D AB CD C O H N S

6. Steven Gollmer Cedarville University Complex Life: Page 6 Irreduceable Complexity What are the chances that all the components of a simple device come together in a functional manner?

7. Critique of IC https://www.youtube.co m/watch?v=4dQJzj2D MrA https://www.youtube.co m/watch?v=K_HVrjKc vrU Steven Gollmer Cedarville University Complex Life: Page 7

8. Steven Gollmer Cedarville University Complex Life: Page 8 Complexification of Cells Autotrophs –Photoautotrophs –Lithautotrophs Thermophilic autotrophic bacteria Heterotrophs –Need environmental organic compounds Prokaryotes –Circular DNA

9. Steven Gollmer Cedarville University Complex Life: Page 9 Beginning of Eukaryotes Endosymbiosis Theory –Lynn Margulis Presence of Organelles –Mitochondria –Chloroplasts Nucleus –Contain genetic material

10. Steven Gollmer Cedarville University Complex Life: Page 10 Additional Changes Animals vs. Plants –Cell membrane vs. cell wall –Plastids Origin of Sex –2 fold cost over parthenogenesis –DNA repair mechanism –Mitosis vs. Meiosis

11. Steven Gollmer Cedarville University Complex Life: Page 11 Common Ancestry

12. Steven Gollmer Cedarville University Complex Life: Page 12 Molecular Ancester DNA Mutation –Molecular Phylogeny –Molecular Clock Prediction –Common animal 0.9 - 1.0 billion YBP Problem –Different trees for different indicators –Lateral Gene Transfer

13. Steven Gollmer Cedarville University Complex Life: Page 13 Cambrian Explosion

14. Steven Gollmer Cedarville University Complex Life: Page 14 Discontinuity Actual Punctuated Equilibrium Darwinian Evolution

15. Paper 3 – Synthetic Biology Craig Venter –Bacteria Genome Press Release (Handout) –Web Site – http://www.jcvi.org/cms/home/ Synthetic Biology –Web Site - http://syntheticbiology.org/ –Bio-Bricks - http://biobricks.org/ –iGEM Competition - http://www.igem.org/Main_Page Write an essay analyzing the benefit of synthetic biology and its value to the creationist community. (No false praise) –Include 3 developments in this area with references to support your claims. –5 points are reserved for clarity and significance of your analysis. Steven Gollmer Cedarville University Complex Life: Page 15