1. Cancer Care Engineering Joe Pekny, PhD Visionary Marietta Harrison, PhD Worker Bee

2. Cancer Care Engineering Current Funding Initiatives Walther Cancer Institute Foundation Engineering the Cancer System (R-CCE) Funded: $1.35M Regenstrief Institute 7/1/07-2009 Focused on Health Services Research Cancer Care Delivery, Modeling & Data Visualization, CCEHub Warfighter CCE (W-CCE) Funded: $2.4M DOD, 12/1/07-2011 Focused on Prevention, Molecular Signatures Sample Acquisition, OMIC Analysis, Data Modeling, Data Visualization, Literature Mining Funded: $0.2M 2007-2009 Dog-CCE (D-CCE) Regenstrief, PCC, DP, Engineering, Vet School Funded: $0.2M 2007-2009

3. Cancer Care Engineering Vision: to harness goal-oriented research to solve the cancer problem using Indiana as model for the nation Approach: create an engineering “Systems Analysis” model for cancer prevention, detection, treatment and care delivery Team: Over seventy physicians, caregivers, engineers, scientists and staff drive the CCE vision

4. 9/05 3/0611/06 9/065/07 6/07 7/074/08 WCCE-1 3/08 IU IRB SRC-1IU IRB SRC-2 6/08 DOD IRB 11/08 CCE Milestones 10/08 Initial DCCE Results Regenstrief CCE Funded Regenstrief CCE Proposal WCCE Proposal Washington WCCE Presentation Indy Foundations Presentation First NIH Proposal CCE is “Born” in Lebanon, IN

5. Cancer Care Engineering The Integrated Pillars Mathematical Models Patient OMIC Analysis Health Services Research Cancer as a Managed Disease

6. Cancer Care Engineering Predictive Biomarkers “OMICS” Patient Blood Genomic Analysis Lipidomic Metabolomic Glycoproteomic

7. Cancer Care Engineering Critical Enablers Interactive Databases -CCEHub Visualization

8. Cancer Care Engineering Mathematical Models Statistical Semi-mechanistic Population-based Agent-based