1. Chapter 13 Meiosis and Sexual Life Cycles

2. Question? u Does Like really beget Like? u The offspring will “resemble” the parents, but they may not be “exactly” like them.

3. Can you pick out the kids for each couple?

4. Heredity u The transmission of traits from parents to offspring. u Comment - Humans have been aware of heredity for thousands of years.

5. Genetics u The scientific study of heredity. u Comment - Genetics is only about 150 years old.

6. Genes u The DNA for a trait. u Locus - the physical location of a gene in a chromosome.

7. Reproduction u A method of copying genes to pass them on to offspring. u Two main types: u Asexual reproduction u Sexual reproduction

8. Asexual Reproduction u Parent passes all of its genes to its offspring. u Uses mitosis. u Also known as cloning. u Comment - many organisms reproduce this way.

9. Asexual Bud

10. Advantages u Only need 1 parent. u Offspring are identical to the parent. u Good genetic traits are conserved and reproduced.

11. Disadvantages u No new DNA combinations for evolution to work on. u Clones may become extinct if attacked by a disease or pest.

12. Sexual Reproduction u Two parents contribute DNA to an offspring. u Comment - most organisms reproduce this way, but it hasn’t been proven in some fungi and a few others.

13. Advantages u Offspring has a unique combination of DNA which may be an improvement over both parents. u New combination of DNA for evolution to work with.

14. Disadvantages u Need two parents. u Good gene combinations can be lost. u Offspring may not be an improvement over the parents.

15. Question ? u Do parents give their whole DNA copy to each offspring? u What would happen to chromosome number if they did?

16. Chromosome Number u Is usually constant for a species. u Examples: u Humans - 46 u Corn - 20 u Onions - 16 u Dogs - 72

17. Life Cycle - if Mitosis Female 46 Male 46 egg 46 sperm 46 Zygote 92 mitosis Mitosis

18. Result u Chromosome number would double each generation. u Need a method to reduce the chromosome number.

19. Life Cycle - if Meiosis Female 46 Male 46 egg 23 sperm 23 Zygote 46 mitosis Meiosis

20. Result u Chromosome number will remain the same with each sexual reproduction event. u Meiosis is used to produce the gametes or sex cells.

21. Homework u Reading – Chapters 13, 46 u Lab - Ps u Chapter 46 – today u Chapter 12 – Friday 11/1

22. Meiosis - Purpose u To reduce the number of chromosomes by half. u Prevents doubling of chromosome numbers during sexual reproduction.

23. Sexual Life Cycle u Has alternation of meiosis and fertilization to keep the chromosome numbers constant for a species.

25. Life Cycle Variations

26. Ploidy u Number of chromosomes in a "set" for an organism. u Or, how many different kinds of chromosomes the species has. u Usually shown as N = …… u Humans N = 23

27. Diploid u 2 sets of chromosomes. u Most common number in body or somatic cells. u Humans 2N = 46 u Corn 2N = 20 u Fruit Flies 2N = 8

30. Haploid u 1 set of chromosomes. u Number in the gametes or sex cells. u Humans N = 23 u Corn N = 10 u Fruit Flies N = 4

31. Polyploids u Multiple sets of chromosomes. u Examples u 3N = triploid u 4N = tetraploid u Common in plants, but usually fatal in animals.

32. Meiosis/Mitosis Preview of differences u Two cell divisions, not one. u Four cells produced, not two. u Synapsis and Chiasmata will be observed in Meiosis

33. Meiosis/Mitosis Preview of differences u 1st division separates PAIRS of chromosomes, not duplicate chromosomes. u Interkinesis is present.

34. Meiosis u Has two cell divisions. Steps follow the names for mitosis, but a “I” or “II” will be added to label the phase.

36. Interphase - Movie

37. Prophase I - Movie

38. Prophase I u Basic steps same as in prophase of Mitosis. u Synapsis occurs as the chromosomes condense. u Synapsis - homologous chromosomes form bivalents or tetrads.

39. Prophase I u Chiasmata observed. u Longest phase of division.

40. Metaphase I - Movie

41. Metaphase I u Tetrads or bivalents align on the metaphase plate. u Centromeres of homologous pairs point toward opposite poles.

42. Anaphase I - Movie

43. Anaphase I u Homologous PAIRS separate. u Duplicate chromosomes are still attached at the centromeres.

44. Anaphase I u Maternal and Paternal chromosomes are now separated randomly.

46. Telophase I - Movie

47. Telophase I u Similar to Mitosis. u Chromosomes may or may not unwind to chromatin. u Cytokinesis separates cytoplasm and 2 cells are formed.

48. Interkinesis u No DNA synthesis occurs. u May last for years, or the cell may go immediately into Meiosis II. u May appear similar to Interphase of Mitosis.

49. Meiosis II u Steps are the same as in Mitosis. u Prophase II u Metaphase II u Anaphase II u Telophase II

50. Meiosis II - Movie

51. Meiosis - Results u 4 cells produced. u Chromosome number halved. u Gametes or sex cells made. u Genetic variation increased.

53. Sexual Sources of Genetic Variation 1. Independent Assortment of Chromosomes during Meiosis. 2. Random Fertilization. 3. Crossing Over.

54. Independent Assortment u There are 23 pairs of chromosomes in humans. u The chance to inherit a single chromosome (maternal or paternal) of each pair is 1/2.

56. Gamete Possibilities u With 23 pairs of chromosomes, the number of combinations of chromosome types (paternal and maternal) are: 2 23 or 8,388,608

57. Random Fertilization u The choice of which sperm fuses with which egg is random.

58. Random Fertilization u Therefore, with 8,388,608 kinds of sperms and 8,388,608 kinds of eggs, the number of possible combinations of offspring is over 64 million kinds.

59. Result u Is it any wonder that two offspring from the same human parents only resemble each other and are not identical twins?

60. Crossing-Over u The exchange of sister chromatid material during synapsis. u Occurs ONLY in Prophase I.

61. Chiasmata u The point of contact where two chromosomes are crossing-over.

62. Crossing-over: Movie

64. Importance u Breaks old linkage groups. u Creates new linkage groups increases genetic variation.

65. Importance u Very common during meiosis. u Frequency can be used to map the position of genes on chromosomes.

66. Comments u Offspring can never be 100% like a parent if sexual reproduction is used. u Multiple cross-overs are common, especially on large chromosomes

67. Comments u Genes near the centromere do not cross-over very often.

68. Summary u Know how the chromosomes separate during Meiosis. u Know how Meiosis differs from Mitosis. u Know how sexual reproduction increases genetic variation.

69. Summary u Use Chapter 46 to look for the differences in Meiosis between human males and females.

70. Sordaria

77. Mitosis/Meiosis Lab Report u Show drawings of the mitosis phases. u Calculate the % of total cells in each of mitosis phases. u Answer questions 1, 2 u Use the Sordaria data to answer questions 1 – 3.