1. Developments at the Nano/Bio Interface Point to Scientific Opportunities Developments at the Nano/Bio Interface Point to Scientific Opportunities Functional Molecules and Hybrid Nanostructures Single Molecule Motion and Complexity

2. Peptide Complexes Designed for Optoelectronic Function Saven, DeGrado, Therien, J. Am. Chem. Soc. 2004 Saven, DeGrado, Therien, (2008) Saven, DeGrado, Therien (2008) Saven, DeGrado, Therien, Blasie, J. Am. Chem. Soc. 2007 Blasie, DeGrado, Therien, Saven J. Am. Chem. Soc. (2008)

3. Interface Mediated Behavior in Hybrid Nanostructures Functional Coxsackie virus-Adenovirus Receptor - Nanotube Hybrid for Detection of Viral Protein (Knob) Johnson and collaborators, Nano Letters 2007 J. Phys. Chem. B 2009 Plasmon Induced Electronic Transport in Functionalized Nanoparticles Bannerjee et al in press NanoLetters 08

4. Ferroelectric Nanolithography Extended to Flexible Substrates The ultimate goal is to assemble multiple components of diverse properties into complex configurations. Ferroelectric Nanolithography achieves this by controlling local electronic structure on substrates that influences electron transfer at the surface. Rankin, et al ACS Nano 2008

5. Absorption in the porphyrin Primary and coupled surface plasmons

6. Plasmon Induced Electronic Transport in Molecules Bannerjee, et al in press

7. Plasmonics Molecular Electronics SERS single molecule properties light guiding switching control optical properties of organicssensing meta materials targeted therapeutics Harry Atwater, Nature Materials 2003 Mark Reed’s Group http://www.eng.yale.edu/reedlab/

8. New mechanism for transduction of optical energy to electrical energy Optical antenna effect focuses light to the nanoparticle junction increasing absorption efficiency, enhancement can be factors of 10 5 or more. Absorption wavelengths/energies can be tuned by choice or design of the molecule and morphological control of nanoparticle array + Ghosh, S.K. and T. Pal,. Chemical Reviews, 2007. 107(11): p. 4797-4862

9. Protein Motion at the Single Molecule Level: Myosin V Processivity Science 2005, 2007 Goldman Group

10. Protein Motion at the Single Molecule Level: Myosin V Processivity Science 2005, 2007 Goldman Group

11. Protein Motion at the Single Molecule Level: Myosin V Processivity Science 2005, 2007 Goldman Group

12. Protein Motion at the Single Molecule Level: Myosin V Processivity Science 2005, 2007 Goldman Group

13. Protein Motion at the Single Molecule Level: Myosin V Processivity Science 2005, 2007 Goldman Group

14. Medalia et al. 2002 Science. 298:1209-13. Grn =  tubules; Red = actin Complexity of the Cytoplasm and Cytoskeleton

15. V Unhindered Motion of Myosin Motors Goldman, Bau, Arsenaut Arsenault, M., Zhao, H., H., Purohit, P., Goldman, Y., and Bau, H. H., 2007, Biophysical Journal 93, L42-L44

16. Glass Actin Gold Electrode 1  m, Myosin-Coated Bead ~2  m Increased Complexity in Protein Environment Goldman, Bau, Shuman Science 2008 J. Biophysics 2009,

17. Whole Lotta Shakin’ Drosophila S2 cell with microtubules shown in red and peroxisomes in green. Recently developed imaging technology allows us to look inside living cells with unprecedented spatial and time resolution (nanometers and milliseconds). Extending this method to two colors allowed us to perceive previously hidden relations between cell components. For example, our work documented correlation between the motions of distant call cargos, indicating that they were both attached to the same active structural element (a microtubule). IM Kulic and PC Nelson, Europhys Lett 2007; IM Kulić, AEX Brown, H Kim, C Kural, B Blehm, PR Selvin, PC Nelson and VI Gelfand, The role of microtubule movement in bidirectional organelle transport. PNAS 2008. We have exquisite information about the static structures of cellular components, but still little understanding of how they orchestrate their many dynamic functions. The understanding now beginning to emerge will influence cell biology over the coming years.

18. Scientific Opportunities Biomolecule platforms and Hybrid nanostructures offer pathways to engineered function pathogen detection protein sensors optoelectronic devices energy harvesting strategies Single molecule studies in the context of realistic environments reveal complex behavior cell division (cancer) disease targets cell motion disease targets live proteomics: in situ protein synthesis Probes of nanoscale phenomena are poised for another revolution