1. Power Point Slide Catalog From PreViser Corporation www.previser.com Expert Validation Study

2. How Good are Dentists and Periodontists at Assessing Risk for Periodontitis? Assessing periodontal disease risk: A comparison of clinicians’ assessment versus a computerized tool G. Rutger Persson, Lloyd A. Mancl, John Martin, Roy Page Journal of the American Dental Association. Volume 134, May 2003. Pages 575 – 582. Courtesy PreViser Corporation, all rights reserved

3. Expert Validation of the OHIS Periodontal Risk Calculator A group of 107 subjects was assembled to manifest a wide range of risk, and a periodontal examination performed A group of 107 subjects was assembled to manifest a wide range of risk, and a periodontal examination performed Based on the records, a risk score from 1 - 5 was determined by the OHIS Based on the records, a risk score from 1 - 5 was determined by the OHIS The records were evaluated individually by one group of 10 periodontists, another group of 6 periodontists and a group of 36 general dentists, and a risk score assigned for each subject The records were evaluated individually by one group of 10 periodontists, another group of 6 periodontists and a group of 36 general dentists, and a risk score assigned for each subject Expert scores were compared statistically to the OHIS- assigned scores Expert scores were compared statistically to the OHIS- assigned scores Courtesy PreViser Corporation, all rights reserved

4. 107 Patient Records, Risk Assessed using OHIS™ Three Expert Groups Subjectively Assess Same Patients OHIS™ Courtesy PreViser Corporation, all rights reserved

5. 107 Patient Records, Risk Assessed using OHIS™ Three Expert Groups Subjectively Assess Same Patients 6 Practicing Experts OHIS™ Courtesy PreViser Corporation, all rights reserved

6. 107 Patient Records, Risk Assessed using OHIS™ Three Expert Groups Subjectively Assess Same Patients 6 Practicing Experts OHIS™ 10 PreViser Founders Courtesy PreViser Corporation, all rights reserved

7. 107 Patient Records, Risk Assessed using OHIS™ Three Expert Groups Subjectively Assess Same Patients 6 Practicing Experts OHIS™ 10 PreViser Founders 36 General Dentists “Periodontally Aware” Courtesy PreViser Corporation, all rights reserved

8. Risk Calculator Score = 3 General Dentist (5 Patient Evaluations… Expert Periodontists (5 Patient Evaluations per data point) Previser Founder’s (5 Patient Evaluations…) Practitioner evaluation over- estimating risk by 2 scores Practitioner evaluation under- estimating risk by 1 score Over- Estimated Risk = Inappropriate Treatment Under- Estimated Risk = Inappropriate Treatment Practitioner evaluation over- estimating risk by 1 score Practitioner evaluation under- estimating risk by 2 scores 20% Agreement with OHIS™ For OHIS™ assessed patients with Risk Score of 3.. Conclusion: Clinicians can’t assess the risk of future disease Courtesy PreViser Corporation, all rights reserved

9. Conclusions There is great variation among practitioners in assessing risk There is great variation among practitioners in assessing risk Agreement between practitioners and the OHIS is poor Agreement between practitioners and the OHIS is poor Probability of an expert clinician assigning given patient a “correct” risk score is remote Probability of an expert clinician assigning given patient a “correct” risk score is remote Relative to the OHIS Risk Calculator, dentists and periodontists underestimate risk, especially for patients in the higher risk groups Relative to the OHIS Risk Calculator, dentists and periodontists underestimate risk, especially for patients in the higher risk groups Courtesy PreViser Corporation, all rights reserved